Synergistic Manganese(I) C−H Activation Catalysis in Continuous Flow: Chemoselective Hydroarylation

Wang, Hui; Pesciaioli, Fabio; Oliveira, João C. A.; Warratz, Svenja; Ackermann, Lutz

doi:10.1002/ange.201708271

Cited by 37 publications

(6 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[54b] Alkynyl cyclic carbonates were also reported as substrates in non-decarboxylative cooperative Brønsted acid/Mn I -catalyzed hydroarylations under continuous flow conditions affording (E)-configured functionalized allylic cyclic carbonates that are useful for latestage diversification. [55] 4. Miscellaneous Heterocyclic Substrates 4.1.…”

Section: Conversion Of Alkynyl-substituted Cyclic Carbonatesmentioning

confidence: 99%

Catalytic Transformations of Functionalized Cyclic Organic Carbonates

et al. 2018

View full text Add to dashboard Cite

Functionalized cyclic organic carbonates and related heterocycles have emerged as highly versatile heterocyclic substrates for ring-opening and decarboxylative catalytic transformations allowing for the development of new stereo- and enantioselective C-N, C-O, C-C, C-S and C-B bond formation reactions. Transition-metal-mediated conversions have only recently been rejuvenated as powerful approaches towards the preparation of more complex molecules. This minireview will highlight the potential of cyclic carbonates and structurally related heterocycles with a focus on their synthetic value and the mechanistic manifolds that are involved upon their conversion.

show abstract

Section: Conversion Of Alkynyl-substituted Cyclic Carbonatesmentioning

confidence: 99%

Catalytic Transformations of Functionalized Cyclic Organic Carbonates

et al. 2018

View full text Add to dashboard Cite

show abstract

“…[17] Recently, Ackermann and coworkers have achieved a highly chemo-and regioselective hydroarylation of O-containing propargylic alkynes under synergistic catalysis of Brønsted acid and manganese (Scheme 4). [18] Indoles, thiophenes, pyrroles, tryptophans, and pyridinones were all suitable arene substrates. It was noteworthy that the β-O-elimination process didn't occur at all in the reaction, which was distinguished from previous manganese-catalyzed hydroarylation reactions with β-heteroatom elimination pathways.…”

Section: Olefination Reactions With Alkynesmentioning

confidence: 99%

Manganese‐Catalyzed C−H Olefination Reactions

Wang

2019

ChemCatChem

View full text Add to dashboard Cite

Olefins are essential building blocks in organic synthesis, the access to which from simple C−H substrates through catalysis of transition metals, in particular the earth's abundant ones meets the requirements of green and sustainable chemistry. Manganese‐catalyzed C−H olefination reactions have emerged as an efficient approach to olefins in recent years, complementary to traditional olefin synthesis. Varieties of alkynes, alkenes, allenes as well as alcohols are successfully applied to the Mn‐catalyzed reactions with C−H substrates, providing multisubstituted olefins bearing varied functional groups. This minireview presents great progresses newly achieved on manganese‐catalyzed C−H olefination reactions.

show abstract

“…506 The authors demonstrated that the manganese(I)-catalyzed hydroarylation protocol tolerated a wealth of challenging functional groups, such as ester, cyano, halo, and carboxyl (Scheme 92). 509 6.3.2. C−H Activation for Annulation.…”

Section: C−h Addition To C−c Multiple Bondsmentioning

confidence: 99%

3d Transition Metals for C–H Activation

et al. 2018

Self Cite

View full text Add to dashboard Cite

C−H activation has surfaced as an increasingly powerful tool for molecular sciences, with notable applications to material sciences, crop protection, drug discovery, and pharmaceutical industries, among others. Despite major advances, the vast majority of these C−H functionalizations required precious 4d or 5d transition metal catalysts. Given the cost-effective and sustainable nature of earth-abundant first row transition metals, the development of less toxic, inexpensive 3d metal catalysts for C−H activation has gained considerable recent momentum as a significantly more environmentally-benign and economically-attractive alternative. Herein, we provide a comprehensive overview on first row transition metal catalysts for C−H activation until summer 2018.

show abstract

Synergistic Manganese(I) C−H Activation Catalysis in Continuous Flow: Chemoselective Hydroarylation

Cited by 37 publications

References 97 publications

Catalytic Transformations of Functionalized Cyclic Organic Carbonates

Catalytic Transformations of Functionalized Cyclic Organic Carbonates

Manganese‐Catalyzed C−H Olefination Reactions

3d Transition Metals for C–H Activation

Contact Info

Product

Resources

About