Synergistic interactions of apigenin, naringin, quercetin and emodin on inhibition of 3T3-L1 preadipocyte differentiation and pancreas lipase activity

Guo, Xiaoxuan; Liu, Jia; Cai, Shengbao; Wang, Ou; Ji, Baoping

doi:10.1016/j.orcp.2015.08.004

Cited by 48 publications

(38 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Guo et al . () similarly found that naringin and emodin synergistically interact to inhibit lipase activities at 0.6 m m . They also observed that apigenin and emodin show synergistic interactions at 0.6 m m .…”

Section: Resultsmentioning

confidence: 82%

“…CI was used to determine the type of interaction, and our results showed that CIs gradually decreased as concentrations increased and reached <0.90 at 50.0 μg mL −1 , suggesting that a synergistic interaction on inhibiting lipase activity only occurred at relative high concentrations of the two compounds. This result was consistent with previous findings (Cai et al ., ; Guo et al ., ). Cai et al .…”

Section: Resultsmentioning

confidence: 97%

See 1 more Smart Citation

Phenolic composition, antioxidant and pancreatic lipase inhibitory activities of Chinese sumac (Rhus chinensis Mill.) fruits extracted by different solvents and interaction between myricetin‐3‐O‐rhamnoside and quercetin‐3‐O‐rhamnoside

Zhang

Zhao

et al. 2017

Int J of Food Sci Tech

Self Cite

View full text Add to dashboard Cite

This work was designed to investigate the phenolic composition, antioxidant and pancreatic lipase inhibitory activities of Rhus chinensis Mill. fruits extracted by different solvents, and to illustrate which major phenolic compounds were responsible for lipase inhibition and to evaluate their interactions. Results showed that R. chinensis Mill. fruits were rich in phenolics, which included 13 types identified and quantified by UHPLC-ESI-HRMS/MS. Among the identified phenolics, myricetin-3-O-rhamnoside and quercetin-3-O-rhamnoside were the most dominant detected in all extracts. Extracts with 80% methanol, 80% ethanol and 80% acetone exhibited strong antioxidant and pancreatic lipase inhibitory activities in vitro, and these activities were positively correlated with phenolic contents. Myricetin-3-O-rhamnoside and quercetin-3-O-rhamnoside demonstrated good lipase inhibitory activities in a dose-dependent manner and synergistically inhibited lipase. This work may provide insights into the potential uses of R. chinensis Mill. fruits in food and nutraceutical industries. Keywords Identification and quantification, lipotoxicity, phenolic profile, reduction in fats intake, UHPLC-ESI-HRMS/MS. *Correspondent: E-mails: caikmust2013@163.com (SC) and mjpangkmust@163.com (MP) International

show abstract

Section: Resultsmentioning

confidence: 82%

Section: Resultsmentioning

confidence: 97%

Phenolic composition, antioxidant and pancreatic lipase inhibitory activities of Chinese sumac (Rhus chinensis Mill.) fruits extracted by different solvents and interaction between myricetin‐3‐O‐rhamnoside and quercetin‐3‐O‐rhamnoside

Zhang

Zhao

et al. 2017

Int J of Food Sci Tech

Self Cite

View full text Add to dashboard Cite

show abstract

“…This indicates that CF partially prevented body weight loss as a result of its hypolipidemic and hypoglycemic effect. Apigenin 7-methyl ether 5-glucoside, a derivative of apigenin, known for its antiobesity properties (Ono and Fujimori, 2011;Guo et al, 2015), was found in CF and may have contributed to reduced visceral fat content and body weight observed in this study. Reports of anti-diabetic effects of other phytochemical constituents of CF are lacking in literature.…”

Section: Discussionmentioning

confidence: 56%

Antidiabetic activities of chloroform fraction of Anthocleista vogelii Planch root bark in rats with diet- and alloxan-induced obesity-diabetes

Anyanwu

Iqbal

Khan

et al. 2019

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Ethnopharmacological relevance: Anthocleista vogelii Planch is a medicinal plant traditionally used in West Africa for the management and treatment of diabetes mellitus. Aim of the study: To determine the antidiabetic activities of chloroform fraction (CF) of Anthocleista vogelii Planch root bark in rats with diet-and alloxan-induced obesity-diabetes. Materials and Methods: Inhibitory activities of CF against α-amylase and α-glucosidase activities were determined in vitro. Three weeks old rats were fed with high-fat diet for 9 weeks to induce obesity prior to further induction of diabetes using alloxan (150 mg/kg body weight, i.p.). Blood glucose levels and body weight were measured every 7 days throughout the experiment. Glucose tolerance was assessed in normal and CF-treated rats on day 21. Terminal blood samples were collected from sacrificed animals for the measurement of serum insulin levels. Pancreases were excised from treated and untreated animals for histopathological examination. Results: LCMS/MS chromatographic profile of CF via positive and negative modes revealed 13 and 23 compounds respectively. Further analysis revealed quebrachitol (QCT), loganin, sweroside, oleoside 11-methyl ester and ferulic acid, which have been previously reported for their antidiabetic activities, as constituents of CF. CF inhibited activities of α-amylase (IC 50 = 51.60 ± 0.92 µg/ml) and α-glucosidase (IC 50 = 5.86 ± 0.97 µg/ml) in a dose-dependent manner. Treatment of animals with obesity-diabetes with 100 and 200 mg/kg CF significantly improved glucose tolerance (P<0.001) and enhanced serum insulin levels (P<0.05) compared to diabetic control rats. Conclusions: Antidiabetic activities of CF might be mediated via inhibition of α-amylase and αglucosidase activities, and enhancement of insulin and leptin sensitivity in obesity-diabetes rats. This study further substantiates the traditional use of A. vogelii in the management and treatment of diabetes in Africa and encourages further studies to investigate its mechanism of action.

show abstract

“…Increased activity of these enzymes impairs glycemic control and promotes the development of diabetes (Tundis, Loizzo, & Menichini, 2010). The inhibition upon pancreatic lipase is a target for developing agent(s) to prevent or ameliorate obesity (Guo, Liu, Cai, Wang, & Ji, 2016) because this enzyme analyzes triglycerides into fatty acids and glycerol in the gastrointestinal tract. When the activity of this lipase is limited, triacylglycerol fails to pass cross the intestinal brush border membrane, and subsequently, the uptake of triacylglycerol into the human body is lowered.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical profiles and anti-diabetic benefits of two edible Amaranthus species

Yang

Mong

et al. 2020

CyTA - Journal of Food

View full text Add to dashboard Cite

Phytochemical profile and activity of anti-oxidative, anti-glycative, anti-α-amylase, anti-αglucosidase, anti-lipase and anti-acetylcholinesterase (AchE) of aqueous extracts prepared from leaf and stem parts of two edible Amaranthus species, white and red amaranths, were investigated. Phytochemical analyses showed that white amaranth had more total phenolic acids than red one. The content of total flavonoids in four examined aqueous extracts was similar. Red amaranth has greater anthocyanins and carotenoids than white one. All aqueous extracts at three concentrations were used for in vitro bio-activities experiments. Results showed that four aqueous extracts displayed radical scavenging effect, Fe 2+ chelating effect, xanthine oxidase inhibition, and reducing power. Aqueous extracts prepared from red amaranth exhibited marked anti-glycative effects, antiα-amylase, anti-α-glucosidase, anti-lipase, and anti-AchE activities. These findings suggested that these two vegetables could be developed as functional foods for diabetic prevention and/or attenuation. Perfiles fitoquímicos y beneficios antidiabéticos de dos especies de Amaranthus comestibles RESUMEN En el presente estudio se investigaron el perfil fitoquímico y las actividades antioxidante, antiglicativa, anti-α-amilasa, anti-α-glucosidasa, anti-lipasa y anti-acetilcolinesterasa (AchE) de extractos acuosos preparados a partir de hojas y tallos de dos especies de Amaranthus comestibles, el amaranto blanco y el rojo. Los análisis fitoquímicos dan cuenta de que el amaranto blanco contiene más ácidos fenólicos totales que el rojo, mientras que el amaranto rojo posee mayor cantidad de antocianinas y carotenoides que el blanco. En cuatro extractos acuosos examinados se constató que el contenido de flavonoides totales era similar. Se utilizaron todos los extractos acuosos a tres concentraciones para realizar experimentos de bioactividad in vitro. Los resultados indican que cuatro extractos acuosos presentaron efecto eliminador de radicales, efecto quelante de Fe 2+ , efecto inhibidor de la xantina oxidasa, así como poder reductor. Los extractos acuosos preparados a partir de amaranto rojo exhibieron marcados efectos anti-glicativos, anti-α-amilasa, anti-α-glucosidasa, anti-lipasa y anti-AchE. Estos hallazgos sugieren que ambos vegetales podrían desarrollarse como alimentos funcionales para la prevención y/o atenuación de la diabetes.

show abstract

Synergistic interactions of apigenin, naringin, quercetin and emodin on inhibition of 3T3-L1 preadipocyte differentiation and pancreas lipase activity

Cited by 48 publications

References 38 publications

Phenolic composition, antioxidant and pancreatic lipase inhibitory activities of Chinese sumac (Rhus chinensis Mill.) fruits extracted by different solvents and interaction between myricetin‐3‐O‐rhamnoside and quercetin‐3‐O‐rhamnoside

Phenolic composition, antioxidant and pancreatic lipase inhibitory activities of Chinese sumac (Rhus chinensis Mill.) fruits extracted by different solvents and interaction between myricetin‐3‐O‐rhamnoside and quercetin‐3‐O‐rhamnoside

Antidiabetic activities of chloroform fraction of Anthocleista vogelii Planch root bark in rats with diet- and alloxan-induced obesity-diabetes

Phytochemical profiles and anti-diabetic benefits of two edible Amaranthus species

Contact Info

Product

Resources

About