Synergistic interaction between tapentadol and flupirtine in the rat orafacial formalin test

The Antinociceptive Effect of a Tapentadol‐Ketorolac Combination in a Mouse Model of Trigeminal Pain is Mediated by Opioid Receptors and ATP‐Sensitive K+ Channels

“…The present study demonstrated that tapentadol produces antinociception in both phases of the orofacial formalin test. This study agrees with previous reports showing that tapentadol produces antinociception when administered systemically in animal models Christoph et al, 2011;Bujalska-Zadro_ zny et al, 2015;Ono et al, 2014] including the orofacial formalin test [Lee et al, 2015]. Furthermore, in the present study a dose-related antinociceptive effect of ketorolac was observed in both phases of the orofacial formalin in agreement with previous observations [Miranda et al, 1993;L opez-Muñoz et al, 2004;Isiordia et al, 2010].…”

“…Furthermore, in the present study a dose-related antinociceptive effect of ketorolac was observed in both phases of the orofacial formalin in agreement with previous observations [Miranda et al, 1993;L opez-Muñoz et al, 2004;Isiordia et al, 2010]. Tapentadol has synergistic effects in rat neuropathic pain models when combined with flupirtine [Lee et al, 2015] and pregabalin [Christoph et al, 2011]. Tapentadol also produces a synergistic interaction with ketorolac in visceral pain models [Zapata-Morales et al, 2016], and, in the present study, a synergistic interaction with ketorolac in the formalin-induced orofacial pain test.…”

Journal clubs: an educational tool for veterinary practitioners

“…The development of these skills ensures that junior researchers do not learn through personal failure and that they are appropriately equipped to develop into successful researchers. In addition, practical research opportunities for junior researchers have been developed because of contacts made through our journal club, [9][10][11][12][13][14] with much of this research still ongoing. For senior members, journal club participation promotes development of new ideas and perspectives and provides the potential to initiate new research studies and collaborations.…”

Pharmacokinetics and disposition of flupirtine in the horse

“…The approved indications for FLU differ between countries but mainly include the clinical management of musculoskeletal pain, post-operative pain, headache, dysmenorrhoea, neuralgia and neuritis, post-traumatic pain (trauma and chemical burns) and pain associated with cancer (Devulder, 2010;Harish et al, 2012). It has not been used to its full potential as an analgesic in the first decade of the 21st century, but there has recently been a resurgence in FLU use after discovery of its powerful additive effects when used with opioids (Goodchild et al, 2008;Capuano et al, 2011;Kolosov et al, 2012;Lee et al, 2015) in addition to its properties when used alone (Wilhelmi, 2013).…”