Synergistic interaction and antibacterial properties of surface-active mono- and di-cationic ionic liquids with ciprofloxacin

Priyanka, V.P.; Harikrishna, A.S.; Kesavan, Venkitasamy; Gardas, Ramesh L.

doi:10.1016/j.molliq.2024.124359

Cited by 2 publications

(1 citation statement)

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“…The larger aggregates of amphiphiles, present in a certain amount in solutions of C 12 BetC 2 Cl at m = 3.3 × CMC, can also be efficient in the solubilization of some hydrophobic drugs due to having more space in their hydrophobic core [51][52][53]. For this reason, the most suitable concentrations for using investigated SAILs (C 10 and C 12 ) as co-surfactants and stabilizers, according to the micellar scheme, are above the CMC.…”

Section: Dynamic Light Scatteringmentioning

confidence: 99%

A Study of the Micellar Formation of N-Alkyl Betaine Ethyl Ester Chlorides Based on the Physicochemical Properties of Their Aqueous Solutions

Geppert-Rybczyńska,

Mrozek-Wilczkiewicz,

Rawicka

et al. 2024

Molecules

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In this study, a series of four surface-active compounds—N-alkyl betaine ethyl ester chlorides, CnBetC2Cl—were synthesized and characterized in aqueous solutions. As with other alkyl betaines, these amphiphiles can be practically used, for example, as co-surfactants and/or solubility enhancers acting according to hydrotropic or micellar mechanisms, depending on the alkyl chain length in the amine. We focused on the representatives of the medium alkyl chain length (C6–C12) to find the dependence between the alkyl chain length in N-alkyl betaine ethyl ester chlorides and the surface, volumetric, acoustic, and viscometric properties of their solutions. Ethyl esters, the derivatives of amino acids, were chosen to increase functionality and take advantage of possible hydrolysis in solutions at higher pH, which is also a key parameter in biodegradability. The micellization parameters were calculated based on the physicochemical characteristics. We focused our interest on the ester with a dodecyl substituent since we can compare and discuss its properties with some other C12 representatives that are available in literature. Surprisingly, its micellization characteristic is almost temperature-independent in the investigated temperature range, t = (15–45) °C. Particularly interesting are the results of dynamic light scattering (DLS), which show that the changes in physicochemical parameters of the C12 homolog around the CMC are caused by the two types of micelles of different sizes present in solutions.

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Section: Dynamic Light Scatteringmentioning

confidence: 99%