Synergistic inhibitory effects of naproxen in combination with magnolol on TPA-induced skin inflammation in mice

Yue, Yuan; Liu, Wenfeng; Zhou, Wei; Chen, Min; Huang, Boxin; Zhang, Lanyue; Wang, Zhenshi; He, Yue; Zhang, Kun; Zheng, Xi; Du, Zhiyun

doi:10.1039/c6ra03926j

Cited by 8 publications

(5 citation statements)

References 27 publications

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“…It has been well established activation of Akt/IKK signaling pathway results in NF‐κB activation (Yue et al, 2016). In this study, we also verified whether such synergism is specific to the Akt/IKK signaling pathway.…”

Section: Resultsmentioning

confidence: 99%

Combination use of tolfenamic acid with curcumin improves anti‐inflammatory activity and reduces toxicity in mice

et al. 2020

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Long‐term use of tolfenamic acid inevitably causes side effects, including gastric ulcer and hepatotoxicity. Curcumin is generally recognized to be anti‐inflammatory, hepatoprotective, and gastroprotective. Herein, we investigated the combinational effects of tolfenamic acid and curcumin and possible mechanism in a TPA‐induced inflammation mouse model. Combinational use of tolfenamic acid (100 mg/kg) and curcumin (100 mg/kg) by oral administration reduced dermal inflammation represented by ear edema and lymphocytic infiltration. Moreover, curcumin dispersed in polyvinyl pyrrolidone showed stronger synergistic effect. The beneficial effect of the coadministration was also reproduced in PKC/Akt/IKK/NF‐κB signaling pathways. Notably, hepatoprotective and gastroprotective effect was exhibited by the reverse of body weight loss and NF‐κB downregulation in the liver, and by increased Spleen Index of mice. These results suggested combination administration of tolfenamic acid with curcumin enhances anti‐inflammatory efficacy and reduces hepatic/gastric toxicity, which indicates dietary uptake of curcumin may facilitate the function of tolfenamic acid. Practical applications Curcumin, a representative polyphenolic compound, is one of the main constituents of dietary spice turmeric which has been widely consumed throughout the world, especially in Asia. The beneficial aspect of combination use of curcumin in enhancing anti‐inflammatory effect and reducing hepatic/gastric toxicity of NSAID drug tolfenamic acid in mice has been explored. It might be anticipated as a potential naturally derived bioactive constituent in functional food and pharmaceutical applications.

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Section: Resultsmentioning

confidence: 99%

Combination use of tolfenamic acid with curcumin improves anti‐inflammatory activity and reduces toxicity in mice

et al. 2020

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“…Experimental evidence has shown that exposure of skin to TPA induces the activation of intracellular pathways through the activation of protein kinase C (PKC), including PI3K/AKT/NF-κB signaling, STAT3 signalling, as well as the generation of inflammatory cytokines (Lai et al, 2007;Yue et al, 2016;Rakariyathama et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Croton stipulaceusKunth, a native Mexican medicinal plant with antioxidant and anti-inflammatory activities

Moreno-Quiros,

Garcia-Escalante,

Sanchez-Medina

et al. 2024

BLACPMA

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Leaves of Croton stipulaceuswere extracted (EHex, ECHCl3and EEtOH extracts) to assesstheir antioxidant potential, anti-inflammatory activity in murine models and acute toxicity. EEtOH showed the highest effect in DPPH (37.80% inhibition), FRAP (1065.00 ± 55.30 μmolFe2+) and total polyphenols (231.24 ± 9.05 meq AG/gM). EHex was the most active, ~ 50% inhibition of TPA-induced ear edema; while EEtOH (dose of 2 mg/ear) showed the highest inhibition in the chronic model (97% inhibition), and inhibited MPO activity (48%). In carrageenan-induced edema, ECHCl3(dose 500 mg/kg) was the most active. None of the extracts showed acute toxicity (LD50) at 2 g/kg (p.o.). This work is the first report that supports the traditional use of C. stipulaceusas an anti-inflammatory.

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“…All procedures were pre‐approved by the center of animal test of Sun Yat‐sen University. Mouse inflammatory tests were conducted using the method of Yue et al . Various concentrations of the EOs (25, 50, and 100 mg/kg) were prepared in peanut oil.…”

Section: Methodsmentioning

confidence: 99%

Variation in Essential Oil and Bioactive Compounds of Curcuma kwangsiensis Collected from Natural Habitats

Zhang

Yang

Huang

et al. 2017

Chemistry & Biodiversity

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The chemical compositions of essential oils (EOs) extracted from Curcuma kwangsiensis rhizomes collected from six natural habitats in P. R. China were evaluated using gas chromatography/mass spectrometry (GC/MS). Fifty-seven components were identified from the six EOs, and their main constituents were 8,9-dehydro-9-formyl-cycloisolongifolene (2.37 - 42.59%), germacrone (6.53 - 22.20%), and l-camphor (0.19 - 6.12%). The six EOs exhibited different DPPH radical-scavenging activities (IC , 2.24 - 31.03 μg/ml), with the activity of most of EOs being much higher than that of Trolox C (IC , 10.49 μg/ml) and BHT (IC , 54.13 μg/ml). Most EOs had potent antimicrobial effects against the tested bacteria and fungus. They also exhibited cytotoxicity against B16 (IC , 4.44 - 147.4 μg/ml) and LNCaP cells (IC , 73.94 - 429.25 μg/ml). The EOs showed excellent anti-inflammatory action by significantly downregulating expression of pro-inflammatory cytokines, cyclooxygenase-2, and tumor necrosis factor-α. This study provides insight into the interrelation among growth location, phytoconstituents, and bioactivities, and the results indicate the potential of C. kwangsiensis as natural nutrients, medicines, and others additives.

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Synergistic inhibitory effects of naproxen in combination with magnolol on TPA-induced skin inflammation in mice

Abstract: A combination of naproxen and magnolol effectively inhibited TPA-induced skin inflammation via blocking PI3K/Akt and PI3K/PKC signaling pathways.

Cited by 8 publications

References 27 publications

Combination use of tolfenamic acid with curcumin improves anti‐inflammatory activity and reduces toxicity in mice

Combination use of tolfenamic acid with curcumin improves anti‐inflammatory activity and reduces toxicity in mice

Croton stipulaceusKunth, a native Mexican medicinal plant with antioxidant and anti-inflammatory activities

Variation in Essential Oil and Bioactive Compounds of Curcuma kwangsiensis Collected from Natural Habitats

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