Synergistic induction of rat microsomal CYP1A1 and CYP1A2 by acetone in combination with pyridine

Iba, Michael M.; Bennett, Susan E.; Storch, Amijoy; Ghosal, Anima; Thomas, Paul E.

doi:10.1016/0304-3835(93)90046-c

Cited by 18 publications

(2 citation statements)

References 15 publications

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“…The elevation of mutagenicity in the Ames test using the acetone-treated S-9 fraction was coincident with the levels of CYP1A1 mRNA induced in liver by acetone treatment. Barnett et al [5] and Iba et al [12] also reported that CYP1A1/2 isoforms, as well as CYP2E1, were induced by acetone given in drinking water or inhaled by rats.…”

Section: Discussionmentioning

confidence: 98%

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Antibiotic Furazolidone Induces CYP1A But Not CYP2E1 Subfamily in Rat Liver

Sasaki

Sakai

Ikenaka

et al. 2008

The Journal of Veterinary Medical Science

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ABSTRACT. Furazolidone (FZ), one of the nitrofuran fungicides, is used as a veterinary medicine in the Middle and Far Eastern countries. In this study, FZ (125 mg/kg) was administered orally to Wistar rats for 3 days. Results of the Ames test using the S-9 fraction of rats treated with FZ showed a significant increase in the number of revertant colonies. Western blot analysis of hepatic CYP isozymes induced by FZ, revealed a remarkable induction of CYP1A1 apoprotein, but CYP1A2 and CYP2E1 apoproteins were not altered. In addition, the expression of CYP1A1 mRNA level in rats treated with FZ by RT-PCR was significantly enhanced by FZ treatment. We concluded that FZ is apparently mutagenic and induces transcription of the CYP1A1 isozyme, which metabolically activates numerous promutagens, in hepatocytes.

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Section: Discussionmentioning

confidence: 98%

“…Acetone, a typical CYP2E1 inducer [5,12], and Sudan III, a potent CYP1A inducer [7], were used as positive controls. Acetone diluted with water was given to four female rats in an oral dose of 5 ml/kg for 3 days.…”

Section: Methodsmentioning

confidence: 99%