Synergistic Hypoxia and Apoptosis Conditioning Unleashes Superior Mesenchymal Stem Cells Efficacy in Acute Graft-versus-Host-Disease
Mohini Mendiratta,
Meenakshi Mendiratta,
Shuvadeep Ganguly
et al.
Abstract:Mesenchymal stem cells (MSCs) have emerged as promising candidates for immune modulation in various diseases that are associated with dysregulated immune responses like Graft-versus-Host-Disease (GVHD). MSCs are pleiotropic and the fate of MSCs following administration is a major determinant of their therapeutic efficacy. In this context, we here demonstrate that hypoxia preconditioned apoptotic MSCs (bone marrow (BM), Wharton Jelly (WJ)) bear more immune programming ability in a cellular model of acute Graft-… Show more
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