Synergistic ferroptosis‐starvation therapy for bladder cancer based on hyaluronic acid modified metal–organic frameworks

Wang, Yu; Xie, Kunfeng; Chen, Wei; Fang, Yunze; Mo, Qixin; Zhang, Henghui; Zhao, Xinlei; Li, Dongqing; Tan, Wanlong; Zhao, Peng; Li, Fēi

doi:10.1002/btm2.10515

Cited by 4 publications

(1 citation statement)

References 42 publications

(78 reference statements)

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“…Among all, one notable solution is to initiate the generation of H 2 O 2 in tumor sites, which could be achieved by glucose oxidase (GOx). − Due to the increased glucose uptake in cancer cells relative to normal tissues, GOx was expected to produce more H 2 O 2 and gluconic acid in cancer cells by catalyzing intracellular glucose. − This catalytic reaction has the potential to induce cell death through cancer starvation therapy. Furthermore, our previous research demonstrated that the consumption of intracellular glucose would disrupt the pentose phosphate pathway (PPP) and inhibit the generation of nicotinamide adenine dinucleotide phosphate oxidase (NADPH) .…”

Section: Introductionmentioning

confidence: 99%

Improved Immune Response for Colorectal Cancer Therapy Triggered by Multifunctional Nanocomposites with Self-Amplifying Antitumor Ferroptosis

Lin,

Chen,

Deng

et al. 2024

ACS Appl. Mater. Interfaces

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Ferroptosis, as a type of regulated cell death, can trigger the release of damage-associated molecular patterns from cancer cells and lead to the enhancement of immune recognition. Fenton reaction-mediated chemodynamic therapy could initiate ferroptosis by generating lipid peroxides, but its efficiency would be greatly restricted by the insufficient H 2 O 2 and antioxidant system within the tumor. Herein, this work reports the successful preparation of H 2 O 2 self-supplied and glutathione (GSH)depletion therapeutic nanocomposites (Cu 2 O@Au) through in situ growth of Au nanoparticles on the surface of cuprous oxide (Cu 2 O) nanospheres. Upon delivery into cancer cells, the released Cu 2 O could consume endogenous H 2 S within colorectal cancer cells to form Cu 31 S 16 nanoparticles, while the released Au NPs could catalyze glucose to generate H 2 O 2 and gluconic acid. The self-supplying endogenous H 2 O 2 and lower acidity could amplify the Cu ion-induced Fenton-like reaction. Meanwhile, the consumption of glucose would reduce GSH generation by disrupting the pentose phosphate pathway. Additionally, the Cu 2+ /Cu + catalytic cycle promotes the depletion of GSH, leading to lipid peroxide accumulation and ferroptosis. It was found that the onset of ferroptosis triggered by Cu 2 O@Au could initiate immunologic cell death, promote dendritic cell maturation and T-cell infiltration, and finally enhance the antitumor efficacy of the PD-L1 antibody. In summary, this collaborative action produces a remarkable antitumor effect, which provides a promising treatment strategy for colorectal cancer.

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Section: Introductionmentioning

confidence: 99%

Improved Immune Response for Colorectal Cancer Therapy Triggered by Multifunctional Nanocomposites with Self-Amplifying Antitumor Ferroptosis

Lin,

Chen,

Deng

et al. 2024

ACS Appl. Mater. Interfaces

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Metal‐Organic Framework‐Based Nanomedicines for Ferroptotic Cancer Therapy

Song,

Xu,

Wang

et al. 2024

Adv Healthcare Materials

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As an iron‐dependent, non‐apoptosis, regulated cell death (RCD) modality, ferroptosis has gained growing attention for cancer therapy. With the development of nanomaterials in the biomedical field, ferroptotic cancer nanomedicine is extensively investigated. Amongst various nanomaterials, metal‐organic frameworks (MOFs) are hybridized porous materials consisting of metal ions or clusters bridged by organic linkers. The superior properties of MOFs, such as high porosity and cargo loading, ease of surface modification, and good biocompatibility, make them appealing in inducing or sensitizing ferroptotic cell death. There are remarkable achievements in the field of MOF‐based ferroptosis cancer therapy. However, this topic is not reviewed. This review will introduce the fundamentals of MOF and ferroptosis machinery, summarize the recent progress of MOF‐based ferroptotic anticancer drug delivery, discuss the benefits and problems of MOFs as vehicles and sensitizers for cancer ferroptosis, and provide the perspective on future research direction on this promising field.

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Single-cell transcriptome analysis reveals the association between histone lactylation and cisplatin resistance in bladder cancer

Li,

Zhang,

Huang

et al. 2024

Drug Resistance Updates

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Synergistic ferroptosis‐starvation therapy for bladder cancer based on hyaluronic acid modified metal–organic frameworks

Cited by 4 publications

References 42 publications

Improved Immune Response for Colorectal Cancer Therapy Triggered by Multifunctional Nanocomposites with Self-Amplifying Antitumor Ferroptosis

Improved Immune Response for Colorectal Cancer Therapy Triggered by Multifunctional Nanocomposites with Self-Amplifying Antitumor Ferroptosis

Metal‐Organic Framework‐Based Nanomedicines for Ferroptotic Cancer Therapy

Single-cell transcriptome analysis reveals the association between histone lactylation and cisplatin resistance in bladder cancer

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