Synergistic extraction of penicillin G with aliphatic alcohols and butyl acetate

Yang, Zhi-Fa; Yu, Shu-Qiu; Chen, Jiayong

doi:10.1002/jctb.280610311

Cited by 7 publications

(7 citation statements)

References 2 publications

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“…Although many types of complex extractants, such as aminebased solvent, aliphatic alcohol, and phosphorus ester, etc. had been applied to recover penicillin G in many studies [7][8][9][10][11], the reactive extraction process had not been adopted in industrial process because the consumption of solvent in the extraction process is large and the solvent is usually expensive [7].…”

Section: Introductionmentioning

confidence: 99%

Facilitated Transport of Penicillin G by Bulk Liquid Membrane with TBP as Carrier

Ren

Zhang

2008

Appl Biochem Biotechnol

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The facilitated transport of penicillin G from aqueous solutions to the stripping phase through bulk liquid membrane (BLM) containing TBP in 3% iso-octanol and n-butyl acetate was studied. Na(2)CO(3) solution was used as the stripping phase. Experiments were performed as a function of stirring rate, TBP concentration and type of diluent in the liquid membrane phase, pH, and initial penicillin G concentration in the feed phase, Na(2)CO(3) concentration in the stripping phase, etc. The results showed that the BLM process could carry out the simultaneous separation and concentration of penicillin G from dilute aqueous solutions, and arise "up-hill" effect due to the characteristic of non-equilibrium mass transfer. The diffusion of penicillin G complex in the liquid membrane phase played an important role in BLM process. The mass transfer mechanism of BLM for this system was also discussed.

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Section: Introductionmentioning

confidence: 99%

Facilitated Transport of Penicillin G by Bulk Liquid Membrane with TBP as Carrier

Ren

Zhang

2008

Appl Biochem Biotechnol

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“…To reduce the losses, Reschke and Schügerl not only suggested the reactive extraction of penicillin G under a mild pH condition (1-3) but also applied the reactive extraction to various kinds of extractors (4)(5)(6)(7). Because of high physical solubility of penicillin G into n-butyl acetate, one of the hydrogen-bond acceptor solvents, it has been used as an organic solvent for reactive extraction of penicillin G by many researchers (8)(9)(10)(11)(12)(13)(14). For all that the amount of physically extracted penicillin G may stand comparison with that of reactively extracted penicillin G in the reactive extraction systems, its physical equilibrium has been simply expressed by the partition of undissociated penicillin acid from aqueous phase to organic phase.…”

Section: Introductionmentioning

confidence: 99%

Physical and Reactive Extraction Equilibria of Penicillin G in a Hydrogen-Bond Acceptor Solvent System

Lee¹

2006

Biotechnol. Prog.

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Physical and reactive extraction equilibria of penicillin G were investigated experimentally and theoretically in the existence of n-butyl acetate as a hydrogen-bond acceptor solvent. Physical extraction equilibrium experiments were carried out varying the pH of aqueous phase and overall penicillin concentration. We compared the experimental data with the calculated results from four physical extraction equilibrium models suggested here and obtained the most reasonable model. Also, penicillin G was reactively extracted using Amberlite LA-2 in n-butyl acetate. The experimental variables were pH of the aqueous phase, overall amine concentration, and overall penicillin concentration. A combined equilibrium model including our physical extraction equilibrium expression and the reactive extraction equilibrium expression suggested by Reschke and Schügerl was used so as to analyze the current reactive extraction equilibrium system. The calculated results from the reactive extraction equilibrium model were in good agreement with the experimental data.

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“…13 In addition to chemical effects which indwell in extraction of organic acids/or phenol from dilute aqueous solution with mixed solvent of trialkyl amine, n-octanol and di(2-ethylhexyl)phosphoric acid (D2EHPA) /or trin-butyl phosphate (TBP), 14 no other synergism of chemical extraction has been reported in the literature until now.…”

Section: Introductionmentioning

confidence: 99%

Synergistic Extraction of Glycolic Acid from Glycolonitrile Hydrolysate

Shi

Houyong

Cao

et al. 2011

Ind. Eng. Chem. Res.

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In this work, glycolic acid was separated from glycolonitrile hydrolysate by an extractant consisting of tri-noctylamnie, tri-n-butyl phosphate, n-octanol, and sulfonated kerosene. In a single equilibrated apparatus, the synergistic effect of the extractant, the influence of diluents composition, the temperature, and the concentration of ammonium sulfate in the hydrolysate on the distribution coefficient of glycolic acid were studied. The extractant loading of glycolic acid was back-extracted by pure water at high temperature. The results show that synergistic effects appear below 1.56 mol 3 L À1 of glycolic acid. When the concentration of glycolic acid is higher than 3.42 mol 3 L À1 , there is either little or no synergism effect. The quantity of ammonium sulfate in the hydrolysate has little effect on the extraction efficiency. Based on material balance, a mathematical model for the synergistic extraction was established. In a Φ50 mm K€ uhni extraction column, glycolic acid was separated continuously from the hydrolysate.

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Synergistic extraction of penicillin G with aliphatic alcohols and butyl acetate

Cited by 7 publications

References 2 publications

Facilitated Transport of Penicillin G by Bulk Liquid Membrane with TBP as Carrier

Facilitated Transport of Penicillin G by Bulk Liquid Membrane with TBP as Carrier

Physical and Reactive Extraction Equilibria of Penicillin G in a Hydrogen-Bond Acceptor Solvent System

Synergistic Extraction of Glycolic Acid from Glycolonitrile Hydrolysate

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