Synergistic Enhancement of MRI with Gd-DTPA and Magnetization Transfer

Tanttu, Jukka I.; Sepponen, Raimo; Lipton, Martin J.; Kuusela, Timo

doi:10.1097/00004728-199201000-00004

Cited by 63 publications

(27 citation statements)

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“…[12][13][14] We speculate that when the brain background signal was suppressed by STC, the contrast between brain background and neuromelanin was likely reinforced by neuromelanin's paramagnetic T1-shortening eŠects. Paramagnetic substances shorten the relaxation times of both free protons and a pool of restricted macromolecule protons compared with the crossrelaxation rate.…”

Section: Magnetic Resonance In Medical Sciencesmentioning

confidence: 92%

“…Paramagnetic substances shorten the relaxation times of both free protons and a pool of restricted macromolecule protons compared with the crossrelaxation rate. 14 Consequently, the MT eŠect in tissue with a substantial concentration of paramagnetic ions is reduced. We hypothesized that MT eŠect could also be used to visualize neuromelanincontaining neurons.…”

Section: Magnetic Resonance In Medical Sciencesmentioning

confidence: 99%

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Visualization of Neuromelanin in the Substantia Nigra and Locus Ceruleus at 1.5T Using a 3D-gradient Echo Sequence with Magnetization Transfer Contrast

et al. 2008

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Section: Magnetic Resonance In Medical Sciencesmentioning

confidence: 92%

Section: Magnetic Resonance In Medical Sciencesmentioning

confidence: 99%

Visualization of Neuromelanin in the Substantia Nigra and Locus Ceruleus at 1.5T Using a 3D-gradient Echo Sequence with Magnetization Transfer Contrast

et al. 2008

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“…In addition, the range of variation of I SS I is reduced from unity to Rls/(Rls + pis). In the high field limit, this leads immediately to the expression now common in the MTC literature (18,34,35), which, for Tl-effects, is where Ms and Ma are the amplitudes of the MRI signal in the presence and absence of saturating off-resonance radiation, proportional to the equilibrium longitudinal magnetization. At lower fields, part of the change in relative MlU signal amplitudes involves no magnetization transfer, but arises from cross relaxation associated with the undispersed w, and w2 terms.…”

Section: Saturation Transfermentioning

confidence: 94%

A molecular theory of relaxation and magnetization transfer: Application to cross‐linked BSA, a model for tissue

Koenig

Brown

1993

Magnetic Resonance in Med

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Homogeneous soft tissue, as regards its magnetic relaxation properties, is well-modeled by solutions of cross-linked protein (see Koenig and Brown, Prog. NMR Spectr. 22, 487 (1991)). Interactions at the solute-solvent interface alter the hydrodynamics of solvent water, and also couple the solute and solvent proton Zeeman energy reservoirs, giving hydrodynamic and cross-relaxation contributions to water proton relaxation that respond differently to deuteration of solvent. We report measurements of the magnetic field dependence of 1/T1 of water protons in cross-linked bovine serum albumin (BSA), for partially deuterated solvent and, in order to separate these two contributions, of 1/T1 of deuterons. The major experimental finding is that, in addition to recently identified water-binding sites on protein (covering approximately 0.2% of the surface) with water lifetimes of about 1 microsecond, there is another group of sites with lifetimes of about 23 ns, covering approximately 2% of the surface, which are evident in both proton and deuteron data. In addition, we have formulated a theory of interfacial proton-proton magnetic interactions which--with these four parameters, plus two that quantify the protein-water coupling at each site--can account for all the proton and deuteron data, in both native and cross-linked BSA.

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“…The clinical efficacy of MTC imaging hinges upon its ability to differentiate tissues according to the amount and mobility of their indigenous macromolecular contents. MTC imaging has been applied to a variety of organs and structures such as the knee joint (6), in delineating the hyaline cartilage-fluid interface; the heart (7), for better visualization of the heart chamber and early detection of myocardium abnormalities; the liver (8-10), in evaluating different liver diseases and the feasibility of MTC in lesion enhancement; the kidney (3), in an attempt to measure the cross-relaxation rate; the leg muscle (11) and other soft tissues (12), for general characterization; and finally the central nervous system, to improve magnetic resonance angiography quality and to characterize brain lesions (13)(14)(15).…”

mentioning

confidence: 99%