Synergistic Enhancement of Itraconazole Dissolution by Ternary System Formation with Pluronic F68 and Hydroxypropylmethylcellulose

Maghraby, Gamal M. El

doi:10.3797/scipharm.0901-08

Cited by 45 publications

(31 citation statements)

References 29 publications

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“…The spectrum of PEG 6000 reveals broad band at 3446 cm -1 , 2887 cm -1 , 1113 cm -1 for the OH group, aliphatic C-H stretching and C-O stretching, respectively. This finding is in good correlation with the previous published data of the same polymer [27]. FTIR spectrums of tested formulations revealed the main absorption bands of indomethacinwith no significant changes compared with the spectrum of pure drug.…”

Section: Fourier Transform Infrared Spectroscopy (Ftir)supporting

confidence: 92%

“…For HPMC, a broad band of hydroxyl group was shown in the range of 3100-3600 cm -1 . This agrees with the published spectrum of the same polymer [26,27]. The spectrum of PEG 6000 reveals broad band at 3446 cm -1 , 2887 cm -1 , 1113 cm -1 for the OH group, aliphatic C-H stretching and C-O stretching, respectively.…”

Section: Fourier Transform Infrared Spectroscopy (Ftir)supporting

confidence: 91%

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Enhancing Dissolution Rate of Indomethacin by in Situ Crystalization; Development of Orally Disintegrating Tablets

Naiem

Essa

Maghraby

2018

Int J Pharm Pharm Sci

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Objective: The main objective of this study was to investigate the potential of in situ crystallization of indomethacin, in presence or absence of hydrophilic materials, to improve drug dissolution with the goal of developing fast disintegrating tablets.Methods: Indomethacin crystals were prepared by bottom up approach. Water containing hydrophilic additive (polymer or/and surfactant) was added to ethanolic solution of indomethacin while stirring. The selected polymers were hydroxylpropylmethyl cellulose E5 (HPMC E5), polyethylene glycol 6000 (PEG6000) and polyvinylpyrrolidone K40 (PVP K40). The surfactants used were Tween80 and Glucire 44/14. The precipitated particles were collected and air dried. Solid state characterization were performed in addition to in vitro release studies in both acidic (0.1 N HCL) and alkaline medium (phosphate buffer pH 6.8). Optimized formulation was selected to develop fast disintegrating tablets.Results: Thermal behavior suggested modulation in crystalline nature with reduction in particle size that was confirmed by X-ray diffraction results. Infrared spectroscopy excluded any interaction between drug and hydrophilic excipients. Drug dissolution in acid media showed slight improve in drug release, while marked increase was observed in the alkaline media. Combination between Tween80 and HPMC (F7) showed the best dissolution parameters with 5-folds enhancement in release efficiency (RE) compared to pure drug. Formula F7 was successively used to formulate fast disintegrating tablets with prompted release of 58% of the loaded dose and RE of 83%. Conclusion:In situ crystallization of indomethacin is a good approach for enhanced dissolution rate with the presence of hydrophilic additives during precipitation process improving the efficiency.

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Section: Fourier Transform Infrared Spectroscopy (Ftir)supporting

confidence: 92%

Section: Fourier Transform Infrared Spectroscopy (Ftir)supporting

confidence: 91%

Enhancing Dissolution Rate of Indomethacin by in Situ Crystalization; Development of Orally Disintegrating Tablets

Naiem

Essa

Maghraby

2018

Int J Pharm Pharm Sci

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“…The amount of drug released at each time interval was calculated and the cumulative amount of drug released was calculated as a function of time to construct the drug release profile (Hiremath et al, 2009). The drug release efficiency (RE) was calculated from the area under the dissolution curve at time t (determined using the nonlinear trapezoidal rule) and expressed as a percentage of the area of the rectangle described by 100% dissolution in the same time (El Maghraby and Alomrani, 2009). …”

Section: In Vitro Release Studiesmentioning

confidence: 99%

Formulation and evaluation of simvastatin buccal film

Maghraby¹,

Abdelzaher²

2015

J App Pharm Sci

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The aim of this work was to develop and evaluate a buccal film for delivery of simvastatin. Buccal films containing carboxymethyl cellulose (CMC) with and without Polyvinylpyrrolidone (PVP) as polymers were prepared. Tween 80 was included with and without propylene glycol (PG) to modulate the characteristics of the films. The films were prepared by solvent casting with drug concentration being maintained at 2.5 mg/cm 2 . In absence of Tween and PG, the films were opaque due to precipitation of drug. PG reduced the swelling index and increased the thickness of the film due to shrinkage. Incorporation of PVP into the films increased the bioadhesion force and time. The rate of drug release depended on the composition of the film with the presence of PVP increasing the release efficiency compared to the corresponding PVP free films. Similarly, incorporation of PG increased the drug release efficiency. Thermal analysis indicated the presence of the drug in amorphous form or as a solid solution in the film components. The developed films are promising for buccal administration of simvastatin.

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“…Samples were mixed with potassium bromide (spectroscopic grade) and compressed into disks using a hydraulic press before scanning from 4000 to 600 cm -1 . The data were analyzed using IR Solution software (version 1.10) (14).…”

Section: Fourier Transform Infrared Spectroscopymentioning

confidence: 99%

Investigation of in situ gelling alginate formulations as a sustained release vehicle for co-precipitates of dextromethrophan and Eudragit S 100

2014

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Alginate vehicles are capable of forming a gel matrix in situ when they come into contact with gastric medium in the presence of calcium ions. However, the gel structure is pH dependent and can break after gastric emptying, leading to dose dumping. The aim of this work was to develop modified in situ gelling alginate formulations capable of sustaining dextromethorphan release throughout the gastrointestinal tract. Alginate solution (2 %, m/m) was used as a vehicle for the tested formulations. Solid matrix of the drug and Eudragit S 100 was prepared by dissolving the drug and polymer in acetone. The organic solvent was then evaporated and the deposited solid matrix was micronized, sieved and dispersed in alginate solution to obtain candidate formulations. The release behavior of dextromethorphan was monitored and evaluated in a medium simulating the gastric and intestinal pH. Drug-polymer compatibility and possible solid-state interactions suggested physical interaction through hydrogen bonding between the drug and the polymer. A significant decrease in the rate and extent of dextromethorphan release was observed with increasing Eudragit S 100 concentration in the prepared particles. Most formulations showed sustained release profiles similar to that of a commercial sustained-release liquid based on ion exchange resin. The release pattern indicated strict control of drug release both under gastric and intestinal conditions, suggesting the potential advantage of using a solid dispersion of drug-Eudragit S 100 to overcome the problem of dose dumping after the rupture of the pH dependent alginate gels.

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Synergistic Enhancement of Itraconazole Dissolution by Ternary System Formation with Pluronic F68 and Hydroxypropylmethylcellulose

Cited by 45 publications

References 29 publications

Enhancing Dissolution Rate of Indomethacin by in Situ Crystalization; Development of Orally Disintegrating Tablets

Enhancing Dissolution Rate of Indomethacin by in Situ Crystalization; Development of Orally Disintegrating Tablets

Formulation and evaluation of simvastatin buccal film

Investigation of in situ gelling alginate formulations as a sustained release vehicle for co-precipitates of dextromethrophan and Eudragit S 100

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