Synergistic effects of the purine analog sulfinosine and curcumin on the multidrug resistant human non-small cell lung carcinoma cell line (NCI-H460/R)

Andjelković, Tijana; Pešić, Milica; Banković, Jasna; Tanić, Nikola; Marković, Ivanka; Ruždijić, Sabera

doi:10.4161/cbt.7.7.6036

Cited by 45 publications

(27 citation statements)

References 37 publications

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“…Furthermore, as reported by Krishna and Mayer (3), the results of the RT-PCR and western blotting suggest that MCPFE acts at inhibiting the expression of MDR 1 and thus reverses MDR. Similar results were obtained on treatment of drug-resistant cancer cells by cucurmin (30).…”

Section: Discussionsupporting

confidence: 75%

Effects of Momordica charantia Extract on the Expression of MDR 1 Gene in Human Lung Cancer Cells

Yuan¹,

Hy²

2014

WIMJ Open

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Section: Discussionsupporting

confidence: 75%

Effects of Momordica charantia Extract on the Expression of MDR 1 Gene in Human Lung Cancer Cells

Yuan¹,

Hy²

2014

WIMJ Open

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“…Consequently, patients undergoing chemotherapy usually suffer from detrimental side effects (Stortecky and Suter 2010). Furthermore, cancer cells develop multi-drug resistance (MDR) proteins to expel the drugs from the cell (Andjelkovic et al 2008). As a promising alternative, socalled antimicrobial peptides (AMPs) have been emerged as anti-cancer agents ( (Baker et al 1993;Bodek et al 2005;Cruciani et al 1991;Makovitzki et al 2009;Papo et al 2006;Warren et al 2001), for recent reviews see (Hoskin and Ramamoorthy 2008;Schweizer 2009)).…”

Section: Introductionmentioning

confidence: 99%

Online monitoring of metabolism and morphology of peptide-treated neuroblastoma cancer cells and keratinocytes

Drechsler¹,

Andrä

2011

J Bioenerg Biomembr

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Antimicrobial peptides are promising anti-cancer agents with a unique mode of action. We established the usage of a chip-based sensor to monitor the dynamic interplay between cells on the chip and peptides and compared it with endpoint tests. Human neuroblastoma cancer cells and spontaneously immortalized non-cancer keratinocytes were perfused with representative peptides (NK-2, NK11, and melittin). The sensor system enabled continuous recording of cell layer impedance (adhesion/ confluence), oxygen consumption (respiration) and extracellular acidification (glycolysis) and provided insights in cell damage, stress response and recovery. Cells responded differentially to peptide treatment. During perfusion, peptides accumulated on the cell surface until they reached a critical concentration. Preceding to cell death, melittin triggered glycolysis, suggesting stress response. NK-2 induced no change in energy metabolism, but led to an increase in impedance, i.e. a temporarily altered morphology, which appeared to be an excellent parameter to detect subtle structural changes of cell layers.

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“…Accumulating evidence from preclinical studies has demonstrated that chemotherapeutic agents combined with curcumin [24][25][26] or fenretinide 27,28 for cancer therapy often provide promising results. Here, we tested the combined effect of curcumin and fenretinide on the growth of NSCLC both in vitro and in vivo.…”

Section: Introductionmentioning

confidence: 99%

Synergistic effect of fenretinide and curcumin for treatment of non-small cell lung cancer

Chen

Wang

et al. 2016

Cancer Biology & Therapy

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Curcumin and fenretinide are 2 well-known and promising chemotherapeutic compounds via various molecular mechanisms. However, the anticancer capacity of either curcumin or fenretinide is limited. This prompted us to examine the combined anticancer effects of curcumin and fenretinide. Our results demonstrate for the first time that there is synergistic anticancer effect of combined treatment with these 2 agents, leading to enhanced cytotoxicity and enhanced expression level of pro-apoptotic protein cleaved PARP in non-small cell lung cancer (NSCLC) cells while showed little toxicity to rat cardiomyoblast normal cells. The combination treatment was also demonstrated to inhibit lung carcinoma growth in vivo. Furthermore, we show that fenretinide or the ER stress inhibitor 4-PBA decreased curcumin-induced Glucose-regulated protein 78 (GRP78) upregulation, and produced a similar enhanced cytotoxic effect. In addition, GRP78 knockdown by siRNA also enhanced the cytotoxic effect of curcumin in A549 and H1299 cells. Our findings suggest that the 2 small molecules, when used in combination, can potentially be effective therapeutic agents for treating NSCLC, at least in part, by regulating endoplasmic reticulum (ER) chaperone protein GRP78.Abbreviations: NSCLC, non-small cell lung cancer; GRP78, Glucose-regulated protein 78; ER, endoplasmic reticulum; 4-PBA, 4-phenylbutyrate; LLC, Lewis lung carcinoma KEYWORDS Curcumin; fenretinide; GRP78; non-small cell lung cancer

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Synergistic effects of the purine analog sulfinosine and curcumin on the multidrug resistant human non-small cell lung carcinoma cell line (NCI-H460/R)

Cited by 45 publications

References 37 publications

Effects of Momordica charantia Extract on the Expression of MDR 1 Gene in Human Lung Cancer Cells

Effects of Momordica charantia Extract on the Expression of MDR 1 Gene in Human Lung Cancer Cells

Online monitoring of metabolism and morphology of peptide-treated neuroblastoma cancer cells and keratinocytes

Synergistic effect of fenretinide and curcumin for treatment of non-small cell lung cancer

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