Synergistic effects of Salvia officinalis L. essential oils and antibiotics against methicillin-resistant Staphylococcus aureus

Milenkovic, T Marina; Božić, Dragana; Slavkovska, Violeta; Lakusic, S Branislava

doi:10.2298/abs141119057m

Cited by 12 publications

(7 citation statements)

References 16 publications

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“…Because of their high antimicrobial activity, they bring hope to stop the growth of resistance among pathogenic microorganisms to synthetic drugs. Combinatorial studies, which involve essential oil blends, showed their synergistic action against multidrug-resistant pathogens like MRSA, Escherichia coli , producing extended spectrum beta-lactamases, and also against yeasts or dermatophytes [14,15,16].…”

Section: Discussionmentioning

confidence: 99%

The Influence of Essential Oil Compounds on Antibacterial Activity of Mupirocin-Susceptible and Induced Low-Level Mupirocin-Resistant MRSA Strains

et al. 2019

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Because of the bacterial drug resistance development, it is reasonable to investigate chemical compounds capable of preventing the spread of resistance to mupirocin (MUP), commonly used in staphylococcal eradication. The objective of the study was to verify the influence of essential oil compounds (EOCs) on the antibacterial activity of MUP against mupirocin-susceptible (MupS) and induced low-level mupirocin-resistant (MupRL) methicillin-resistant Staphylococcus aureus (MRSA) strains. The following parameters were examined: MRSAMupS and MRSAMupRL susceptibility to EOCs (1,8-cineole, eugenol, carvacrol, linalool, (-)-menthone, linalyl acetate, and trans-anethole), the bacterial cell size distribution, and chemical composition by the use of Fourier Transform Infrared Spectroscopy (FTIR) and Raman spectroscopies. The MRSAMupS and MRSAMupRL strains were susceptible to all tested EOCs. 1,8-cineole and (-)-menthone showed synergistic activity against MRSAMupS in combination with mupirocin, whereas 1,8-cineole exhibited synergistic activity against MRSAMupRL as well. In-depth analysis showed that both MRSAMupS and MRSAMupRL displayed similar distributions of the bacterial cell size. The FTIR and Raman spectra of the MRSAMupS and MRSAMupRL strains showed differences in some regions. New bands in the MRSAMupRL Raman spectrum were observed. It was concluded that the use of 1,8-cineole in combination with mupirocin can increase the mupirocin activity against the MRSAMupS and MRSAMupRL strains.

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Section: Discussionmentioning

confidence: 99%

The Influence of Essential Oil Compounds on Antibacterial Activity of Mupirocin-Susceptible and Induced Low-Level Mupirocin-Resistant MRSA Strains

et al. 2019

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“…In a recent study, Thyme EO is able to reduce of 59.7–85.0 % biofilm biomass formed by methicillin resistant Staphylococcus aureus (MRSA) strains, while Lavandula multifida L. EO showed anti‐MRSA activity since the inhibition diameters reached 27 mm and MIC s were lower than 0.1 μg/mL in a study against 14 strains . Synergistic effects of sub‐inhibitory concentrations of Salvia officinalis EO and different antibiotics against MRSA were also evaluated by Milenković et al . Authors highlighted the presence of different interactions between tested oil and antibiotics from synergistic to antagonistic on different clinical isolates of MRSA suggesting the necessity for systematic in vitro studies of interactions of EOs and antibiotics to reveal any undesirable combinations.…”

Section: Essential Oils: Very Old ‘Guys’ With Great Prospectsmentioning

confidence: 99%

New Tricks for Old Guys: Recent Developments in the Chemistry, Biochemistry, Applications and Exploitation of Selected Species from the Lamiaceae Family

Napoli

Siracusa

Ruberto

2020

Chemistry & Biodiversity

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Lamiaceae is one of the largest families of flowering plants comprising about 250 genera and over 7,000 species. Most of the plants of this family are aromatic and therefore important source of essential oils. Lamiaceae are widely used as culinary herbs and reported as medicinal plants in several folk traditions. In the Mediterranean area oregano, sage, rosemary, thyme and lavender stand out for geographical diffusion and variety of uses. The aim of this review is to provide recent data dealing with the phytochemical and pharmacological studies, and the more recent applications of the essential oils and the non‐volatile phytocomplexes. This literature survey suggests how the deeper understanding of biomolecular processes in the health and food sectors as per as pest control bioremediation of cultural heritage, or interaction with human microbiome, fields, leads to the rediscovery and new potential applications of well‐known plants.

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“…Recently, it has been proved that the essential oil isolated from young leaves of Dalmatian sage (Salvia officinalis L.) also has an antimicrobial effect on certain human pathogens, and that the use of essential oil potentiated the inhibitory effect of antibiotics against methicillin-resistant Staphylococcus aureus (MRSA) 4 .…”

Section: Introductionmentioning

confidence: 99%

Composition and antimicrobial activity of essential oils of Salvia fruticosa and Salvia ringens (Lamiaceae)

et al. 2022

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Background/Aim. Plant essential oils (EOs) can have a significant antibacterial effect especially through additive or synergistic action as antibiotic adjuvants. We investigated the composition and activity of EOs of two species of genus Salvia from Greece with an aim to evaluate their antimicrobial activity as well as the activity of essential oil in combination with selected antibiotics. Methods. The aerial parts of wild-growing S. fruticosa and S. ringens were subjected to a steam distillation and the obtained EOs were analyzed by gas chromatography and gas chromatography/mass spectrometry. The brothmicrodilution method was used in order to determine the minimum inhibitory concentrations (MICs) of essential oils on seven strains of bacteria and one yeast. The antimicrobial activity of the combination of essential oil and antibiotics was investigated by checkerboard method and estimated by calculating the fractional inhibitory concentration (FIC) of each component and the fractional inhibitory concentration index (FICI). Results. Dominant component of S. fruticosa essential oil was trans-thujone (54.2%), and for S. ringens essential oil it was α-pinene (28.1%). The MICs of essential oils of both species were in the range from 200 μg/ml to >500 μg/ml. The strongest antimicrobial effect was achieved against B. subtilis and C. albicans. According to FICI values essential oil of S. fruticosa had additive effect with ciprofloxacin against most of bacterial strains but not with amikacin. Conclusion. The essential oils of S. ringens and S. fruticosa showed modest antimicrobial activity, however essential oil of S. fruticosa showed a promising additive effect in combination with ciprofloxacin.

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Synergistic effects of Salvia officinalis L. essential oils and antibiotics against methicillin-resistant Staphylococcus aureus

Cited by 12 publications

References 16 publications

The Influence of Essential Oil Compounds on Antibacterial Activity of Mupirocin-Susceptible and Induced Low-Level Mupirocin-Resistant MRSA Strains

The Influence of Essential Oil Compounds on Antibacterial Activity of Mupirocin-Susceptible and Induced Low-Level Mupirocin-Resistant MRSA Strains

New Tricks for Old Guys: Recent Developments in the Chemistry, Biochemistry, Applications and Exploitation of Selected Species from the Lamiaceae Family

Composition and antimicrobial activity of essential oils of Salvia fruticosa and Salvia ringens (Lamiaceae)

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