Synergistic effects of NGF, CNTF and GDNF on functional recovery following sciatic nerve injury in rats

Effects of Extracorporeal Shock Wave Therapy on Functional Recovery and Neurotrophin-3 Expression in the Spinal Cord after Crushed Sciatic Nerve Injury in Rats

“…NT-3 facilitates axonal regeneration and the degree of histomorphologic or electrophysiologic limitation according to the nervous injury (Chen et al 2010). It has an important role in axonal extension, survival and maintenance of neurons, myelination and regeneration of neural fibers (Li et al 2006).…”

Simultaneous Inferior Alveolar Nerve Regeneration and Osseointegration With a Nerve Growth Factor-Supplying Implant: A Preliminary Study

“…[15][16][17][18] NGF also can promote regeneration of the peripheral nerve. [19][20][21] However, despite extensive previous research, the clinical application of NGF for IAN damage has been impeded, primarily because of its very short in vivo half-life. 22 Hence, NGF should be applied directly to the damaged site to maintain the effective dose for as long as needed.…”

A rapid, novel model of culturing cranial nerve X-derived motoneurons for screening trophic factor outgrowth response

“…Viability assays confirmed that the motoneuron outgrowth and branching effects were independent of changes in motoneuron viability. This suggests that CN X-derived motoneurons are not influenced by paired NFs in a fashion similar to peripheral and embryonic neurons, [17][18][19][20] supporting unique in vitro behavior of CN X motoneurons.…”

“…While dissociated cultures from dorsal root ganglia, peripheral, and embryonic motoneurons have been critical in contributing to the panoply of knowledge that exists today on NFs and neuropathic conditions, neuronal responses to NFs differ in a myriad of ways depending on motoneuron site, developmental stage, timing of initial therapy, and NF concentration. [17][18][19][20][21] Thus, establishing a model specific to the study of CN X motoneurons in culture is essential if the unique pathophysiology associated with CN X regeneration is to be unveiled. While the model ultimately may be used to investigate the molecular mechanisms of CN X motoneuron regeneration, this study's identification of CNTF as a promoter of CN X outgrowth may treatment groups showed no significant effect on mean motoneuron branching when compared to saline controls.…”