Synergistic effects of mupirocin and an isoflavanone isolated from Erythrina variegata on growth and recovery of methicillin-resistant Staphylococcus aureus

Satô, Masaru; Tanaka, Hitoshi; Yamaguchi, Ryosuke; Kato, Kuniki; Etoh, Hideo

doi:10.1016/j.ijantimicag.2004.03.020

Cited by 49 publications

(41 citation statements)

References 32 publications

(31 reference statements)

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“…The antimicrobial and resistance modifying potentials of naturally occurring flavonoids and polyphenolic compounds have been reported in other studies, such as Cushnie and Lamb, (2005) and Sato et al (2004). This would suggest that the synergy with antibiotics observed in this study could be attributable to such compounds.…”

Section: Organism Tet+ Pen G+ Ery+ Amx+ Cip + Chl+ Oxt+ Amp + Extractsupporting

confidence: 84%

“…There are indications that some herbal materials can act as antibiotic resistant inhibitors (Gibbons et al, 2002, Yam et al, 1998. Combinations of some herbal materials and different antibiotics might affect the inhibitory effect of these antibiotics (Sato et al, 2004). Such combinations would be synergistic if there is a decrease in the MIC of each agent of four-fold; partially synergistic if there is a MIC decrease for one drug of four-fold and a decrease of two-fold of the other agent; additive if there is a two-fold reduction in the MIC of both agents; indifference is all interactions not meeting the criteria listed above and not being antagonistic.…”

Section: Organism Tet+ Pen G+ Ery+ Amx+ Cip + Chl+ Oxt+ Amp + Extractmentioning

confidence: 99%

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Synergistic interaction of Helichrysum pedunculatum leaf extracts with antibiotics against wound infection associated bacteria

2009

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The effect of combinations of the crude methanolic extract of the leaves of Helichrysum pedunculatum and eight first-line antibiotics were investigated by time kill assays against a panel of bacterial strains that have been implicated in wound infections. The plant extract showed appreciable antibacterial activities against the test bacteria with zones of inhibition ranging between 18 and 27 mm, and minimum inhibitory concentrations (MICs) varying between 0.1 and 5.0 mg/ml. The MICs of the test antibiotics range between 0.001 and 0.412 mg/ml, and combination of the plant extract and the antibiotics resulted in reduction of bacterial counts by between 0 and 6.63 Log 10 cfu/ml. At 1 / 2 MIC, 56.81% synergy; 43.19% indifference and no antagonism were observed, and at MIC levels, 55.68% synergy; 44.32% indifference and no antagonism were observed when the extracts were combined with eight different antibiotics. In all, 60% of the interactions were synergistic. All combination regimes on Staphylococcus aureus ATCC 6538 yielded no synergy, neither was antagonism detected in any of the assays. We propose that extracts of the leaves of Helichrysum pedunculatum could be of relevance in combination therapy and as a source of resistance modifying principles that could be useful as treatment options for persistent wound infections.

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Section: Organism Tet+ Pen G+ Ery+ Amx+ Cip + Chl+ Oxt+ Amp + Extractsupporting

confidence: 84%

Section: Organism Tet+ Pen G+ Ery+ Amx+ Cip + Chl+ Oxt+ Amp + Extractmentioning

confidence: 99%

Synergistic interaction of Helichrysum pedunculatum leaf extracts with antibiotics against wound infection associated bacteria

2009

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“…Combination chemotherapy is often employed in clinical practice for the treatment of infectious diseases. Substantial research trials have been done to investigate the interaction effects of medicinal plant extracts with known clinical drugs in the treatment of various ailments, with several of them yielding positive interaction effects (Sato et al, 2004;Filoche et al, 2005;Prabhakar and Doble, 2009). Combinations of different medicinal plant components in the herbal formulation remedies are increasingly becoming a common phenomenon in most traditional medicinal systems.…”

Section: Plant Speciesmentioning

confidence: 99%

In vitro antimicrobial synergism within plant extract combinations from three South African medicinal bulbs

Ncube

Finnie

Staden

2012

Journal of Ethnopharmacology

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“…The plates were incubated at 37 • C for 24 h after which the numbers of colonies were counted and the mean counts (cfu/mL) for each test and controls were calculated and expressed as log 10 . According to [36,37], interactions were considered synergistic when the antibacterial agent combinations achieved ≥2 log 10 cfu/mL decrease in average viable colony counts when compared to average viable colony count achieved by most active single agents. They were considered additive or indifferent when the colony count decrease achieved is <2 log 10 cfu/mL, and antagonistic when average colony count of the combination is ≥2 log 10 cfu/mL as compared to that achieved by most active single agents.…”

Section: Antibiotic-extract Combination Experimentsmentioning

confidence: 99%

Synergistic Effects of n-Hexane Fraction of Parkia biglobosa (Jacq.) Bark Extract and Selected Antibiotics on Bacterial Isolates

2017

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Abstract:The incidence of resistance to commonly used antimicrobial agents by microbial pathogens demands increased effort in the development of effective ways of treating infections and diseases. The n-hexane fraction of lyophilized crude bark extract of Parkia biglobosa (Jacq.) was prepared and, in combination with selected antibiotics, assayed for antimicrobial activity against some selected bacterial pathogens using time-kill assay. Protein leakage analysis of the combined agents was performed using Bradford protein quantification method. Determination of active compounds present in the n-hexane fraction was done using Fourier Transform Infrared Spectroscopy (FTIR). While time-kill assay detected 43.33% synergy; 56.67% indifference and no antagonism at 1/2 × minimum inhibitory concentration (MIC), 1 × MIC exhibited 55% synergy, 45% indifference and no antagonism. Protein leakages from the cells of selected bacteria ranged from 1.20 µg/mL to 256.93 µg/mL. The presence of a phenyl group, an aromatic ring and phenolic compounds in the n-hexane fraction was confirmed at 2162 cm −1 -2020 cm −1 , 1605 cm −1 -1533 cm −1 and 1438 cm −1 -1444 cm −1 spectra peaks, respectively. The observed antibiotic−n-hexane fraction synergistic interaction revealed the improved antibacterial activity of the selected antibiotics. Hence, exploration of a combination of antibiotics with plant secondary metabolites is hereby advocated in the global quest for means of combating infectious diseases caused by multidrug-resistant pathogens.

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Synergistic effects of mupirocin and an isoflavanone isolated from Erythrina variegata on growth and recovery of methicillin-resistant Staphylococcus aureus

Cited by 49 publications

References 32 publications

Synergistic interaction of Helichrysum pedunculatum leaf extracts with antibiotics against wound infection associated bacteria

Synergistic interaction of Helichrysum pedunculatum leaf extracts with antibiotics against wound infection associated bacteria

In vitro antimicrobial synergism within plant extract combinations from three South African medicinal bulbs

Synergistic Effects of n-Hexane Fraction of Parkia biglobosa (Jacq.) Bark Extract and Selected Antibiotics on Bacterial Isolates

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