Synergistic effects of interleukin-1β and interleukin-17A antibodies on collagen-induced arthritis mouse model

Zhang, Yu; Ren, Guangxin; Guo, Ming; Ye, Xianlong; Zhao, Juanjuan; Xu, Liming; Qi, Jianying; Kan, Fangming; Liu, Miaomiao; Li, Deshan

doi:10.1016/j.intimp.2012.12.010

Cited by 49 publications

(39 citation statements)

References 41 publications

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“…Cytokine IL-17, a major product of T cells, which plays an important role as an upstream mediator of RA pathogenesis, and promotes inflammation via enhancing the production of IL-1β, TNF-α, and IL-6 (28,29), significantly increased in rats with AA compared to the healthy controls in our study. In response to treatment with CDS, its level significantly decreased.…”

Section: Discussionsupporting

confidence: 51%

Antiinflammatory effect of herbal preparations on adjuvant arthritis in rats

Akramas¹,

Leonavičienė²,

Bradūnaitė³

et al. 2017

Turk J Vet Anim Sci

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The present study aimed to investigate the antiinflammatory effects of 2 herbal extracts (CDS and CDSM) in rats with experimental adjuvant arthritis (AA). Joint swelling, development of polyarthritis, blood indices, pro/antioxidant activity, and proinflammatory cytokine IL-17 in blood serum, as well as the liver and paw histopathology and histochemistry, were assessed. Oral injections of extracts showed an antiinflammatory effect analogous to that of diclofenac (DF), improved blood indices and suppressed level of IL-17, significantly diminished joint swelling, and histological changes in the joints. Increase in CAT activity and AOA and reduction in lipid peroxidation was noted. The preparations did not show toxic effects on the liver. The obtained results suggest that the prophylactic use of CDS and CDSM have a significant effect on slowing AA progression, similar to the effect of DF. Both preparations could be potential preventive or therapeutic candidates for the treatment of autoimmune processes in combination with other drugs.

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Section: Discussionsupporting

confidence: 51%

Antiinflammatory effect of herbal preparations on adjuvant arthritis in rats

Akramas¹,

Leonavičienė²,

Bradūnaitė³

et al. 2017

Turk J Vet Anim Sci

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“…a b s t r a c t 26 To investigate anti-arthritic activity of luteolin (Lut) in Freund's complete adjuvant (FCA)-induced arthri- 27 tis (AA) in rats. AA was induced by injecting with Freund's complete adjuvant (FCA).…”

mentioning

confidence: 99%

“…IL-1b has pre-214 viously been shown to be increased in synovial tissue[24] and cor-215 related with histological features of arthritis[25]. IL-17 promotes216 inflammation via enhancing the production of IL-1b, TNF-a, and IL-6[26]. Accumulated data suggest that IL-17 contributes to the 218 pathogenesis of RA.…”

mentioning

confidence: 99%

Anti-arthritic activity of luteolin in Freund’s complete adjuvant-induced arthritis in rats by suppressing P2X4 pathway

Shi

Dun

et al. 2015

Chemico-Biological Interactions

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“…In contrast, neutralizing IL-17 itself has proven to be a rather unsatisfactory method for blocking Th17 cell-mediated disease, giving only partial efficacy, which suggests that additional factors may be more important in Th17-mediated disease (16)(17)(18). Recent reports demonstrated that not IL-17A, but GM-CSF was critical for the pathogenesis of Th cells in experimental autoimmune encephalomyelitis, which had been known as a Th17-mediated disease (19,20).…”

mentioning

confidence: 99%

GM-CSF but Not IL-17 Is Critical for the Development of Severe Interstitial Lung Disease in SKG Mice

Shiomi

Usui

Ishikawa

et al. 2014

The Journal of Immunology

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Interstitial lung disease (ILD) is a common complication and sometimes a prognostic factor of connective tissue diseases (CTDs) in humans. However, suitable animal model of severe CTD-associated ILD (CTD-ILD) has been limited. In this study, we showed that zymosan-treated SKG mice developed not only arthritis but also chronic–progressive ILD with high mortality over several months. The pathological and clinical features of ILD in zymosan-treated SKG mice were similar to that of human severe CTD-ILD. ILD in this mouse was characterized by massive infiltration of Th17 cells, GM-CSF–producing CD4+ T cells, and CD11b+ Gr1+ neutrophils with fibrosis. Naive SKG T cells were skewed to differentiate into GM-CSF–producing cells, and GM-CSF secreted by T cells enhanced IL-6 and IL-1β production by macrophages, which in turn enhanced differentiation of IL-17A– and/or GM-CSF–producing T cells and infiltration of neutrophils into lung. Neutralization of GM-CSF completely blocked the development of this ILD, and the blocking of IL-6 signaling resulted in partial prevention of it, whereas neutralization of IL-17A did not. In contrast, the progression of arthritis was inhibited by the neutralization of GM-CSF and slightly by the neutralization of IL-17A, but not by the blocking of IL-6 signaling. These data suggested zymosan-treated SKG mice could be a useful mouse model of severe CTD-ILD, and GM-CSF, rather than IL-17A or IL-6, contributed to the development of ILD in zymosan-treated SKG mice, indicating that neutralization of GM-CSF would be a useful therapeutic strategy for severe CTD-ILD.

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Synergistic effects of interleukin-1β and interleukin-17A antibodies on collagen-induced arthritis mouse model

Cited by 49 publications

References 41 publications

Antiinflammatory effect of herbal preparations on adjuvant arthritis in rats

Antiinflammatory effect of herbal preparations on adjuvant arthritis in rats

Anti-arthritic activity of luteolin in Freund’s complete adjuvant-induced arthritis in rats by suppressing P2X4 pathway

GM-CSF but Not IL-17 Is Critical for the Development of Severe Interstitial Lung Disease in SKG Mice

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