Effects of helium and hydrogen production on irradiation hardening of martensitic steel F82H (Fe-8Cr-2W-0.2V-0.04Ta-0.1C) were examined by dual or triple beam experiments. The effects of tempering and cold working were also examined. The irradiations were performed at about 500 C to 50 dpa under simultaneous dual beams of 10.5 MeV Fe 3þ and 1.05 MeV He þ or triple beams of those and 380 keV H þ ions. The value of appm-He/dpa for the dual ion beams was about 15, and the values of appm-He/dpa and appm-H/dpa for the triple ion beams were 15 and 15 (or 150), respectively. The hardness of the irradiated specimens measured at room temperature using a micro indentation after the irradiations. Irradiation softening and hardening was observed in F82H-std, F82H+20%CW and a non-tempered F82H steels irradiated at about 500 C to 18 and 50 dpa, respectively, by dual ion beams. The hardness of the specimens irradiated at about 500 C to 18 dpa under triple ion beams was harder than that under dual ion beams.