Synergistic Effects of Glutathione and Vitamin E on ROS Mediated Ethanol Toxicity in Isolated Rat Hepatocytes

Gupta, Ankush; Singh, Sangram; Jamal, Farrukh; Nath, Som; Mehrotra, Santosh; Sharma, Bechan

doi:10.3923/ajb.2011.347.356

Cited by 22 publications

(2 citation statements)

References 18 publications

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“…Exposure to GNPs can result in inflammation, death of tubular epithelial cells, increased capillary permeability, blood loss, and inflammatory cell infiltration. [3][4][5][6][7][8] Vit E is a critical fat-soluble antioxidant that supports mitosis, immune function, speeds of blood clotting, and serves as a natural defense against oxidative stress in tissues. Vit E also contributes to cell membrane function, elasticity, and integrity.…”

Section: Introductionmentioning

confidence: 99%

<p>The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles</p>

Abdelhalim¹,

Qaid²,

AL-Mohy³

et al. 2020

IJN

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Background: Recently, use of nanotechnology in biomedical applications such as drug delivery and diagnostic and therapeutic tools has increased greatly. This study evaluated gold nanoparticle (GNPs)-induced nephrotoxic effects in rats in vivo, and examined protective effects of alpha-lipoic acid (α-Lip) and Vitamin E (Vit E) against nephrotoxicity, lipid peroxidation, and inflammatory kidney damage induced by GNPs. Materials and Methods: Twenty-four male Wistar-Kyoto rats (220-240 g, 12 weeks old) were dosed with 50 μL of 10 nm GNPs administered intraperitoneally with or without 200 mg/ kg/day Vit E or 200 mg/kg/day α-Lip. Serum was prepared for biochemical analyses. Kidney function was evaluated through measurement of creatinine (CR), uric acid (URIC), and blood urea nitrogen (BUN). Oxidative stress and lipid peroxidation were evaluated by measurement of reduced glutathione (GSH) and malondialdehyde (MDA) in kidney tissue homogenates. Results and Conclusions: The results showed a significant rise in serum kidney function biomarkers including urea, URIC, CR, and BUN in GNP-treated rats compared to normal control rats. Furthermore, GNPs led to decreased GSH and elevated MDA levels. Vit E or α-Lip supplementation showed a beneficial effect against nephrotoxicity, lipid peroxidation, and inflammatory kidney damage induced by GNPs. This study suggests that use of natural antioxidants in combination with GNPs may be a useful tool in preventing GNPs toxicity.

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Section: Introductionmentioning

confidence: 99%

<p>The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles</p>

Abdelhalim¹,

Qaid²,

AL-Mohy³

et al. 2020

IJN

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“…Additionally, AGD is a precursor of GSH. The GSH is an important antioxidant (Alteheld et al, 2005) and regenerates VE in fish (Gupta et al, 2011). Vitamin E is not only a strong antioxidant to protect fish against oxidative stress and disease (Ding et al, 2018; Niu et al, 2014; Noguchi, 2019), but also an activator of PPARα (González‐Calvo et al, 2014) and a promotor of PPARα gene expression (Ding et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Growth performance, antioxidant indexes, and the expression of genes were considerably promoted by dietary supplementation of alanyl‐glutamine and vitamin E in juvenile marine medaka in seawater acidification by carbon dioxide

Liu

et al. 2023

J World Aquaculture Soc

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The experiment was conducted to study the effect of different dietary supplementation of alanyl‐glutamine dipeptide (AGD) and/or vitamin E (VE) on the growth performance, antioxidant indexes, and the expression of glutathione peroxidase (GPx) and peroxisome proliferator‐activated receptor α (PPARⱭ) genes in juvenile marine medaka (Oryzias melastigma) in seawater acidification. Seven groups of juvenile marine medaka in triplicate were studied in an ecosystem. One of them was in normal seawater (pH 8.1, pH control), and the others were in seawater acidification (pH 7.7) regulated by carbon dioxide (CO2). The juveniles were separately fed for 10 weeks using one of six different diets. The six diets were one control diet (basic feed) without supplements and the other diets with different amounts of additional AGD and/or VE. The juveniles were sampled randomly for analysis of a whole fish in week 0 and week 10. The results showed that different dietary supplementation of AGD and/or VE could considerably promote the growth performance, antioxidant indexes, and the expression of GPx and PPARα genes of juvenile marine medaka in seawater acidification. The optimal diet was D4, with additional AGD 5 g and VE 50 IU per kg of dried feed.

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Tools and Targeted Genes for Plant Disease Detection

Munusamy

Abdullah

2017

Crop Improvement

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Synergistic Effects of Glutathione and Vitamin E on ROS Mediated Ethanol Toxicity in Isolated Rat Hepatocytes

Cited by 22 publications

References 18 publications

<p>The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles</p>

<p>The Protective Roles of Vitamin E and α-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles</p>

Growth performance, antioxidant indexes, and the expression of genes were considerably promoted by dietary supplementation of alanyl‐glutamine and vitamin E in juvenile marine medaka in seawater acidification by carbon dioxide

Tools and Targeted Genes for Plant Disease Detection

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