Synergistic effects of gene polymorphisms of the renin–angiotensin–aldosterone system on essential hypertension in Kazakhs in Xinjiang

Niu, Shudong; Zhou, Bin; Zhang, Keyong; Zhu, Pengcheng; Li, Jingping; Sun, Yujing; He, Ning; Zhang, Mingtao; Gao, Zhiying; Li, Xueyan; Simayi, Amuti; Ge, Jie; Cong, Mingyu; Zhou, Wenna; Qiu, Changchun

doi:10.3109/10641963.2015.1060985

Cited by 17 publications

(15 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They observed that DD genotype frequency was higher in HT patients than controls, and II genotypes were similar in both groups (10 (29). Previous studies demonstrated that there were (13). In Turkish population, contrary to our results, Gunes et al found significant difference between AGT1R A1166C polymorphism allele frequencies and HT.…”

Section: Discussioncontrasting

confidence: 99%

See 1 more Smart Citation

Effects of Interactions among Gene Polymorphisms of the Renin–Angiotensin-Aldosterone System on Hypertension in Turkish People from Southeast Anatolia

Arpacı

Urhan-Kucuk

Bayramoglu

et al. 2019

Revista Romana De Medicina De Laborator

View full text Add to dashboard Cite

Introduction: Hypertension (HT) is characterized by high blood pressure. The reninangiotensin-aldosterone system (RAAS) plays a crucial role in blood pressure (BP) regulation by maintaining vascular tone and the water-sodium balance. We aimed to investigate whether there is any relation between AGT (M235T), ACE (I/D), and AGTR1 (A1166C) genetic polymorphisms and hypertension among Turkish people from Southeast Anatolia. Method and Results: A total of 210 individuals, consisting of 102 healthy controls and 108 patients with essential hypertension admitted to the Cardiology Department of the Adıyaman University Research and Application Hospital were included the study. DNA isolation was performed from the blood samples via commercial kit. Genotype determination was determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Statistically significant differences were found between the control and patient groups in terms of genotype distribution and allelic frequencies of ACE I/D polymorphisms. Significant differences were found in the frequencies of ICM, DCM, DCT, DAT between the patient and control groups. Conclusions: In this study, we found a significant association of ACE I/D polymorphism with HT, and we showed that the I allele can increase the risk of HT in Turkish people from Southeast Anatolia. Although we did not find any association between independent AGT M235T and AGT1R A1166C polymorphisms and HT, we observed that the DCM, DCT, and DAT haplotypes of ACE/AGT1R/AGT polymorphisms reduced the risk of hypertension, while the ICM haplotype increased it.

show abstract

Section: Discussioncontrasting

confidence: 99%

“…RAAS genes including ACE, AGT, and AGT1R are polymorphic genes. There are many studies investigating the relation between RAAS gene polymorphisms and the development and incidence of HT; however, conflicting results were also reported (3,10,(12)(13)(14)(15). It is possible that selection criteria of patients, environmental factors (e.g.…”

Section: Introductionmentioning

confidence: 99%

Effects of Interactions among Gene Polymorphisms of the Renin–Angiotensin-Aldosterone System on Hypertension in Turkish People from Southeast Anatolia

Arpacı

Urhan-Kucuk

Bayramoglu

et al. 2019

Revista Romana De Medicina De Laborator

View full text Add to dashboard Cite

show abstract

“…The ACE I/I genotype confers a low risk of cerebral infarction or other cerebral vascular pathology, such as cerebral white matter changes, in patients with AD. In contrast, the ACE D/D genotype is involved in susceptibility to hypertension . Hypertension, cerebrovascular diseases and cerebral white matter changes negatively affect cognition .…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, the ACE D/D genotype is involved in susceptibility to hypertension. 22,23 Hypertension, cerebrovascular diseases and cerebral white matter changes negatively affect cognition. 24,25 Therefore, considering vascular pathology, the ACE I/I genotype should confer a protective effect in the clinical course of AD.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin‐converting enzyme insertion/deletion polymorphism and the longitudinal progression of Alzheimer's disease

Chou

et al. 2016

Geriatrics Gerontology Int

View full text Add to dashboard Cite

show abstract

“…Aldosterone plays a detrimental role on the cerebrovascular and the cardiovascular system, and it increases oxidative stress, which causes endothelial dysfunction and accumulation of collagen, leading to reduced elasticity of vessel walls. 6 The aldosterone synthase gene (CYP11B2) locus is an important candidate region in the development of hypertension, 7 diabetic nephropathy, 8 type 2 diabetes mellitus, 9 and atrial fibrillation. 10 Because it has been suggested in a meta-analysis that the CYP11B2 -344T/C polymorphism was associated with ischemic stroke, 11 we suspect that this polymorphism is probably associated with the development of TIA.…”

Section: Introductionmentioning

confidence: 99%

Lack of association between CYP11B2 -344T/C polymorphism and transient ischemic attack in a Chinese population

et al. 2020

View full text Add to dashboard Cite

Objective This study investigated whether the CYP11B2 -344T/C polymorphism is correlated with transient ischemic attack (TIA) susceptibility. Methods We recruited 100 TIA patients and 100 control subjects and analyzed the CYP11B2 -344T/C polymorphism using restriction fragment length polymorphism (PCR–RFLP). Results The frequency in TIA patients and controls was 42% compared with 48% for TT genotypes, 51% compared with 45% for TC genotypes, and 7% compared with 7% for CC genotype, respectively. Allele frequencies in TIA patients and controls were 67.5% compared with 70.5% for T-allele and 32.5% compared with 29.5% for C-allele, respectively. No association between the CYP11B2 -344T/C polymorphism and TIA was observed in all comparisons. Conclusion Our data suggest that there was no association between the CYP11B2 -344T/C polymorphism and TIA in a Chinese population.

show abstract

Synergistic effects of gene polymorphisms of the renin–angiotensin–aldosterone system on essential hypertension in Kazakhs in Xinjiang

Cited by 17 publications

References 18 publications

Effects of Interactions among Gene Polymorphisms of the Renin–Angiotensin-Aldosterone System on Hypertension in Turkish People from Southeast Anatolia

Effects of Interactions among Gene Polymorphisms of the Renin–Angiotensin-Aldosterone System on Hypertension in Turkish People from Southeast Anatolia

Angiotensin‐converting enzyme insertion/deletion polymorphism and the longitudinal progression of Alzheimer's disease

Lack of association between CYP11B2 -344T/C polymorphism and transient ischemic attack in a Chinese population

Contact Info

Product

Resources

About