Synergistic effects of diet and exercise on hippocampal function in chronically stressed mice

Hutton, Craig P.; Déry, Nicolas; Rosa, Elyse; Lemon, Jennifer A.; Rollo, C. David; Boreham, Douglas R.; Fahnestock, Margaret; deCatanzaro, Denys; Wojtowicz, J. Martin; Becker, Suzanna

doi:10.1016/j.neuroscience.2015.09.005

Cited by 27 publications

(16 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, a promising target for interventions in this wide range of disorders is to upregulate neurogenesis levels and associated neurotrophic factors. Increasing neurogenesis and neurotrophic factor levels via exercise, diet, and environmental enrichment may impart neuroprotection against stress, aging, and dementia . Also, there may be important interactions among these factors in promoting optimal learning and a healthy brain …”

Section: Resultsmentioning

confidence: 99%

Neurogenesis and pattern separation: time for a divorce

Becker

2016

WIRES Cognitive Science

View full text Add to dashboard Cite

The generation of new neurons in the adult mammalian brain has led to numerous theories as to their functional significance. One of the most widely held views is that adult neurogenesis promotes pattern separation, a process by which overlapping patterns of neural activation are mapped to less overlapping representations. While a large body of evidence supports a role for neurogenesis in high interference memory tasks, it does not support the proposed function of neurogenesis in mediating pattern separation. Instead, the adult-generated neurons seem to generate highly overlapping and yet distinct distributed representations for similar events. One way in which these immature, highly plastic, hyperactive neurons may contribute to novel memory formation while avoiding interference is by virtue of their extremely sparse connectivity with incoming perforant path fibers. Another intriguing proposal, awaiting empirical confirmation, is that the young neurons' recruitment into memory formation is gated by a novelty/mismatch mechanism mediated by CA3 or hilar back-projections. Ongoing research into the intriguing link between neurogenesis, stress-related mood disorders, and age-related neurodegeneration may lead to promising neurogenesis-based treatments for this wide range of clinical disorders. WIREs Cogn Sci 2017, 8:e1427. doi: 10.1002/wcs.1427 For further resources related to this article, please visit the WIREs website.

show abstract

Section: Resultsmentioning

confidence: 99%

Neurogenesis and pattern separation: time for a divorce

Becker

2016

WIRES Cognitive Science

View full text Add to dashboard Cite

show abstract

“…The model was based on numerous human studies which used a variety of forms of enrichment to induce the reserve phenomenon reviewed in (Merkley and Wojtowicz, 2016). Running is known to reliably induce increases in adult neurogenesis and enhance cognitive function in animals and in humans (Déry et al, 2013; Hutton et al, 2015). The six-week period of running was based on a previous study and is sufficient to produce a maximal effect since running reached a maximum at that period (see Materials and Methods).…”

Section: Discussionmentioning

confidence: 99%

Early-Age Running Enhances Activity of Adult-Born Dentate Granule Neurons Following Learning in Rats

Shevtsova

Tan

Merkley

et al. 2017

eNeuro

View full text Add to dashboard Cite

Cognitive reserve, the brain’s capacity to draw on enriching experiences during youth, is believed to protect against memory loss associated with a decline in hippocampal function, as seen in normal aging and neurodegenerative disease. Adult neurogenesis has been suggested as a specific mechanism involved in cognitive (or neurogenic) reserve. The first objective of this study was to compare learning–related neuronal activity in adult-born versus developmentally born hippocampal neurons in juvenile male rats that had engaged in extensive running activity during early development or reared in a standard laboratory environment. The second objective was to investigate the long-term effect of exercise in rats on learning and memory of a contextual fear (CF) response later in adulthood. These aims address the important question as to whether exercise in early life is sufficient to build a reserve that protects against the process of cognitive aging. The results reveal a long-term effect of early running on adult-born dentate granule neurons and a special role for adult-born neurons in contextual memory, in a manner that is consistent with the neurogenic reserve hypothesis.

show abstract

“…The result of the study showed adolescent-onset exercise tipped toward increased AHN and enhanced neurogenesis, compare to adult-onset exercise [ 39 ]. Neuroplasticity is modulated by exercise intensity, interval, and duration, thus increasing BDGF, responsible for immature neuroblasts to proliferate and to increase its survival [ 40 , 41 ]. The level of activity in a treadmill also improves learning, memory, and long-term potentiation, according to the study performed in mice [ 42 ].…”

Section: Reviewmentioning

confidence: 99%

Role of Lifestyle in Neuroplasticity and Neurogenesis in an Aging Brain

Maharjan

Bustamante

Ghattas

et al. 2020

Cureus

View full text Add to dashboard Cite

Neuroplasticity is the brain's ability to transform its shape, adapt, and develop a new neuronal connection provided with a new stimulus. The stronger the electrical stimulation, the robust is the transformation. Neurogenesis is a complex process when the new neuronal blast cells present in the dentate gyrus divide in the hippocampus. We collected articles from the past 11 years for review, using the Medical Subject Headings (MeSH) strategy from PubMed. Quality appraisal was done for each research article using various assessment tools. A total of 24 articles were chosen, applying all the mentioned inclusion and exclusion criteria and reviewed. The reviewed studies emphasized that modifiable lifestyle factors such as diet and exercise should be implemented as an intervention in the elderly for healthy aging of the brain, as the world's aging population is going to be increased, leading to the expansion of health care and cost. Multiple studies have publicized the relation of diet and exercise with cognition function in aging people. A diet consisting of curcumin in its food has its anti-oxidative property, which prevents rapid aging of the brain, other diet patterns such as a caloric restriction diet can influence brain plasticity and preclude the decline of memory. Exercise can increase brain-derived growth factor (BDGF), vascular endothelial growth factor (VEGF), synapsin one, and tyrosine kinase activity that can expand the size of the brain, enhance the plasticity and neurogenesis. This review aimed at exploring lifestyle factors that contribute to neuroplasticity and neurogenesis. Thus, providing a new path for clinicians and researchers to map out the future possible significant benefits for optimal brain aging in a healthy fashion.

show abstract

Synergistic effects of diet and exercise on hippocampal function in chronically stressed mice

Cited by 27 publications

References 77 publications

Neurogenesis and pattern separation: time for a divorce

Neurogenesis and pattern separation: time for a divorce

Early-Age Running Enhances Activity of Adult-Born Dentate Granule Neurons Following Learning in Rats

Role of Lifestyle in Neuroplasticity and Neurogenesis in an Aging Brain

Contact Info

Product

Resources

About