Synergistic effects of anti-PDL-1 with ablative radiation comparing to other regimens with same biological effect dose based on different immunogenic response

Alinezhad, Maedeh; Bakhshandeh, Mohsen; Rostami, Elham; Alimohamadi, Reza; Mosaffa, Nariman; Jalali, Seyed Amir

doi:10.1371/journal.pone.0231507

Cited by 10 publications

(8 citation statements)

References 35 publications

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“…A super flab bolus material of 1.5 cm was located above the tumor. The distance between the source and mouse skin was 100 cm [14,15].…”

Section: Treatmentmentioning

confidence: 99%

“…We utilized three different fractionation schemes; a single high-dose, hypofractionated, and hyperfractional (conventional) RT with the same biological effect dose (BED). Compared to another regimen, a single high dose RT augmented the numbers of immune cells in the TME and was the most efficient in combination with αPDL-1 mAb [14]. Therefore, we decided to examine the potency of combination therapy of single high dose RT plus anti-CD47 immune checkpoint inhibitor compared to single therapies for tumor control.…”

Section: Introductionmentioning

confidence: 99%

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Combining ablative radiotherapy and anti CD47 monoclonal antibody improves infiltration of immune cells in tumor microenvironments

et al. 2022

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Radiotherapy as an anti-tumor treatment can stimulate the immune system. However, irradiated tumor cells express CD47 to escape the anti-tumor immune response. Anti- CD47 Immunotherapy is a possible way to tackle this problem. This study evaluated the effect of single high dose radiotherapy combined with an anti-CD47 monoclonal antibody (αCD47 mAb) in CT26 tumor‐bearing BALB/c mice. We assessed the tumors volume and survival in mice 60 days after tumor implantation. Also, immune cell changes were analyzed by flow cytometry in tumors, lymph nodes, and spleen. Combination therapy enhanced the anti-tumor response in treated mice by increasing CD8+ T cells and M1 macrophages and decreasing M2 macrophages and myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment (TME). Also, our results showed that combination therapy increased survival time in mice compared to other groups. Furthermore, tumor volumes remarkably decreased in mice that received a single high dose RT plus αCD47 mAb. In conclusion, we showed that combining RT and αCD47 mAb improved the immune cell population in TME, regressed tumor growth, and increased survival in tumor-bearing mice.

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“…A super flab bolus material of 1.5 cm was located above the tumor. The distance between the source and mouse skin was 100 cm [14,15].…”

Section: Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Combining ablative radiotherapy and anti CD47 monoclonal antibody improves infiltration of immune cells in tumor microenvironments

et al. 2022

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“…Therefore, the timing of these two treatments must be considered for optimal tumor regression. Several other studies and clinical trials have expanded on and shown the significant anti-tumor effects of radiotherapy combined with PD-L1 inhibitors or regulatory T cell depletion (32)(33)(34)(35)(36)(37)(38).…”

Section: Immune System Suppressionmentioning

confidence: 99%

Overcoming Resistance to Immunotherapy in Head and Neck Cancer Using Radiation: A Review

et al. 2021

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Radiation therapy remains at the center of head and neck cancer treatment. With improvements in treatment delivery, radiation therapy has become an affective ablative modality for head and neck cancers. Immune checkpoint inhibitors are now also playing a more active role both in the locally advanced and metastatic setting. With improved systemic options, local noninvasive modalities including radiation therapy are playing a critical role in overcoming resistance in head and neck cancer. The aim of this review is to describe the role of radiation therapy in modulating the tumor microenvironment and how radiation dose, fractionation and treatment field can impact the immune system and potentially effect outcomes when combined with immunotherapy. The review will encompass several common scenarios where radiation is used to improve outcomes and overcome potential resistance that may develop with immunotherapy in head and neck squamous cell carcinoma (HNSCC), including upfront locally advanced disease receiving definitive radiation and recurrent disease undergoing re-irradiation. Lastly, we will review the potential toxicities of combined therapy and future directions of their role in the management of HNSCC.

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“…In contrast to previous model attempts, it accounts for the dynamics of cell death considering a time distribution of immune response after irradiation, and it will be benchmarked against a broad set of experimental preclinical data taken from the literature. 1,[8][9][10][11][12][13][14][15][16] Methods and Materials…”

Section: Introductionmentioning

confidence: 99%

A Predictive Biophysical Model of the Combined Action of Radiation Therapy and Immunotherapy of Cancer

Friedrich

Scholz

Durante

2022

International Journal of Radiation Oncology*Biology*Physics

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Synergistic effects of anti-PDL-1 with ablative radiation comparing to other regimens with same biological effect dose based on different immunogenic response

Abstract: Introduction

Cited by 10 publications

References 35 publications

Combining ablative radiotherapy and anti CD47 monoclonal antibody improves infiltration of immune cells in tumor microenvironments

Combining ablative radiotherapy and anti CD47 monoclonal antibody improves infiltration of immune cells in tumor microenvironments

Overcoming Resistance to Immunotherapy in Head and Neck Cancer Using Radiation: A Review

A Predictive Biophysical Model of the Combined Action of Radiation Therapy and Immunotherapy of Cancer

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