Synergistic effects of anlotinib and DDP synergy in breast cancer treatment: inhibiting of cell growth and migration, and augmenting apoptosis and autophagy via modulation of the VEGF/JAK2/STAT3 axis
Hongmei Zhang,
Chunling Liu,
Ye Jin
et al.
Abstract:Anlotinib has been shown to have good anti-tumor effects in a variety of tumors, including breast cancer (BRCA); however, the combined anti-tumor efficacy of anlotinib and DDP in BRCA, as well as the underlying mechanism, remain to fully elucidated. This study aims to explore the role of VEGFA expression in BRCA and the therapeutic efficacy of anlotinib, alone and in combination with cisplatin (DDP), in treating BRCA. BRCA cells were treated with or without anlotinib and/or DDP. The proliferation, migration an… Show more
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