Synergistic effect of spermidine and ciprofloxacin against Alzheimer disease in male rat via ferroptosis modulation
Menna M Youssef,
Tarek M Mohamed,
Aza M Bakry
et al.
Abstract:Alzheimer's disease (AD) is a prevalent form of neurodegenerative disease with a complex pathophysiology that remains not fully understood, and the exact mechanism of neurodegeneration is uncertain. Ferroptosis, a programmed cell death mechanism mediated by iron, has been linked to the progression of degenerative diseases observed in clinical AD models. In this study, we aimed to explore the synergistic effects of spermidine and/or ciprofloxacin in combating Alzheimer's disease (AD). We investigated AD-related… Show more
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