Synergistic effect of polystyrene nanoplastics and contaminants on the promotion of insulin fibrillation

Li, Chuanxi; Ma, Yingying; Liu, Xiao; Huang, Renliang; Su, Rongxin; Qi, Wei; Che, Jinjing; He, Zhimin

doi:10.1016/j.ecoenv.2021.112115

Cited by 26 publications

(16 citation statements)

References 39 publications

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“…Of the remaining 84 articles, only two were not experimental studies. Within the 82 experimental studies a total of 163 different particle types were studied (Alimi et al, 2021;Astner et al, 2020;Bergami et al, 2019;Cai et al, 2018;Canesi et al, 2016;Chakraborty et al, 2021;Chen et al, 2018Chen et al, , 2020Cunha et al, 2020;de Oliveira et al, 2020;Della Torre et al, 2014;Dong et al, 2019aDong et al, , 2019bEliso et al, 2020;Fadare et al, 2019;Frankel et al, 2020;Ganguly and Ariya, 2019;González-Fernández et al, 2019;Grassi et al, 2020;Khoshnamvand et al, 2021;Kihara et al, 2019;C. Li et al, 2021;X.…”

Section: Methodsmentioning

confidence: 99%

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U–Pb geochronology of Variscan granitoids from the Moroccan Meseta (Northwest Africa): Tectonic implications

et al. 2023

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Section: Methodsmentioning

confidence: 99%

“…Finally, the development of numerical models underpinned by high-quality experimental research is a promising way to assess the fate of nanoplastics in the environment (Besseling et al, 2017;C. Li et al, 2021;Lins et al, 2022;Wang et al, 2021).…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

U–Pb geochronology of Variscan granitoids from the Moroccan Meseta (Northwest Africa): Tectonic implications

et al. 2023

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“…The formation of the protein corona depends on several parameters such as the size, shape, and chemical composition of the NPs, but also the medium (i.e., type of proteins and other chemical species), the duration of exposure, and the NPs/protein ratio. A molecular dynamic study [ 74 ] revealed that the interactions between insulin and polystyrene NPs are primarily driven by Van der Waals forces and hydrophobic interactions: these interactions occur primarily due to apolar amino acids such as leucine and alanine. NPs immersed in biological fluids combine with proteins in a dynamic process, and their interaction produces NP-protein complexes.…”

Section: Mnps and Proteinsmentioning

confidence: 99%

“…These results suggest that NPs may cause protein misfolding [ 76 ]. Further computational studies provide additional evidence of protein denaturation and conformational changes in the presence of NPs: when peptide models characterized by different secondary structures were simulated in the presence of polyethylene and nylon NPs, both NPs were found to influence the stability of the native secondary structures of the peptides [ 74 , 76 , 77 ].…”

Section: Mnp Effects On Protein Secondary Structuresmentioning

confidence: 99%

“…The process leading to the formation of amyloid fibrils and plaques is called fibrillogenesis: insulin can form amyloid fibrils and is typically selected as a model protein to study the fibrillation process. Li et al [ 74 ] examined the fibrillation of insulin promoted by polystyrene NPs. The results suggest that the presence of NPs decreased the lag phase time for insulin fibrillation, but there is no significant effect on the other two phases.…”

Section: Mnps and Aberrant Protein Foldingmentioning

confidence: 99%

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Micro- and Nanoplastics’ Effects on Protein Folding and Amyloidosis

Windheim

Colombo

Battajni

et al. 2022

IJMS

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A significant portion of the world’s plastic is not properly disposed of and, through various processes, is degraded into microscopic particles termed micro- and nanoplastics. Marine and terrestrial faunae, including humans, inevitably get in contact and may inhale and ingest these microscopic plastics which can deposit throughout the body, potentially altering cellular and molecular functions in the nervous and other systems. For instance, at the cellular level, studies in animal models have shown that plastic particles can cross the blood–brain barrier and interact with neurons, and thus affect cognition. At the molecular level, plastics may specifically influence the folding of proteins, induce the formation of aberrant amyloid proteins, and therefore potentially trigger the development of systemic and local amyloidosis. In this review, we discuss the general issue of plastic micro- and nanoparticle generation, with a focus on their effects on protein folding, misfolding, and their possible clinical implications.

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Genotoxic and neurotoxic potential of intracellular nanoplastics: A review

Casella,

Ballaz

2024

J of Applied Toxicology

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Plastic waste comprises polymers of different chemicals that disintegrate into nanoplastic particles (NPLs) of 1–100‐nm size, thereby littering the environment and posing a threat to wildlife and human health. Research on NPL contamination has up to now focused on the ecotoxicology effects of the pollution rather than the health risks. This review aimed to speculate about the possible properties of carcinogenic and neurotoxic NPL as pollutants. Given their low‐dimensional size and high surface size ratio, NPLs can easily penetrate biological membranes to cause functional and structural damage in cells. Once inside the cell, NPLs can interrupt the autophagy flux of cellular debris, alter proteostasis, provoke mitochondrial dysfunctions, and induce endoplasmic reticulum stress. Harmful metabolic and biological processes induced by NPLs include oxidative stress (OS), ROS generation, and pro‐inflammatory reactions. Depending on the cell cycle status, NPLs may direct DNA damage, tumorigenesis, and lately carcinogenesis in tissues with high self‐renewal capabilities like epithelia. In cells able to live the longest like neurons, NPLs could trigger neurodegeneration by promoting toxic proteinaceous aggregates, OS, and chronic inflammation. NPL genotoxicity and neurotoxicity are discussed based on the gathered evidence, when available, within the context of the intracellular uptake of these newcomer nanoparticles. In summary, this review explains how the risk evaluation of NPL pollution for human health may benefit from accurately monitoring NPL toxicokinetics and toxicodynamics at the intracellular resolution level.

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Synergistic effect of polystyrene nanoplastics and contaminants on the promotion of insulin fibrillation

Cited by 26 publications

References 39 publications

U–Pb geochronology of Variscan granitoids from the Moroccan Meseta (Northwest Africa): Tectonic implications

U–Pb geochronology of Variscan granitoids from the Moroccan Meseta (Northwest Africa): Tectonic implications

Micro- and Nanoplastics’ Effects on Protein Folding and Amyloidosis

Genotoxic and neurotoxic potential of intracellular nanoplastics: A review

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