Synergistic effect of polymorphisms in uncoupling protein 1 and β 3 -adrenergic receptor genes on basal metabolic rate in obese Finns

Valve, Raisa; Heikkinen, Sami; Rissanen, Aila; Laakso, Markku; Uusitupa, Matti

doi:10.1007/s001250050915

Cited by 98 publications

(66 citation statements)

References 24 publications

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“…The frequency of G allele was 0.48, almost the same as the rate of previous reports in Japan, 29,30 but higher than in other studies in Canada, 7 France, 8 Finland, 9,31,32 and Denmark. 33 This polymorphism is not associated with the clinical features of abnormality.…”

Section: Discussionsupporting

confidence: 82%

Synergistic effect of polymorphisms of uncoupling protein 1 and β3-adrenergic receptor genes on autonomic nervous system activity

et al. 2001

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OBJECTIVE:To investigate the association of the promoter region 73826 A to G polymorphism of the uncoupling protein 1 (UCP1) gene with autonomic nervous system (ANS) activity and the interaction of the polymorphism with the Trp64Arg polymorphism of the b3 adrenergic receptor (b3AR). SUBJECTS: Three-hundred and forty-nine young (mean age 20.4 AE 2.1 y old), healthy Japanese males. MEASUREMENTS: DNA was extracted from whole blood and genotyped by polymerase chain reaction restriction fragment length polymorphism. Plasma glucose, plasma insulin and body mass index (BMI) were measured. Frequency of family history of diabetes or obesity was determined by interview. Subjects randomly chosen from each genotype were examined for ANS activity during supine rest and standing by electrocardiogram power spectral analysis of heart rate variability. RESULTS: UCP1 or b3AR polymorphism was not associated with BMI, plasma glucose, plasma insulin and frequency of family history of diabetes or obesity. The inhibitory effect of UCP1 polymorphism on ANS activity was observed only with occurrence of the variant of b3AR. The very low frequency component associated with thermoregulation in the sympathetic nervous system of homozygotes of UCP1 (GG) at supine rest was signi®cantly lower than normal (AA, 203.2 AE 50.3 vs 462.2 AE 83.6 ms 2 ; mean AE s.e., P 0.021). A higher response to postural change to standing was also observed in both sympathetic and parasympathetic nervous activities of AA than of GG. CONCLUSION: While UCP1 polymorphism alone does not affect ANS activity, it has a synergistic effect with b3AR polymorphism in decreasing sympathetic nervous system activity.

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Section: Discussionsupporting

confidence: 82%

Synergistic effect of polymorphisms of uncoupling protein 1 and β3-adrenergic receptor genes on autonomic nervous system activity

et al. 2001

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“…Also, the frequency of the Trp64Arg polymorphism was similar to those reported in previous studies in Caucasian populations, 15 ± 17 whereas in the present study population the A?G polymorphism was slightly less common than in the study populations reported previously. 5 ± 6,8 In accordance with a growing number of recent studies, 6,8,18 we could not ®nd any cross-sectional or longitudinal association between the Trp64Arg polymorphism of the b 3 AR gene and body weight or BMI. Also, in line with previous ®ndings, 8 no associations between the A?G polymorphism of the UCP1 gene and BMI or body weight gain could be observed, although this polymorphism has been suggested to be associated with higher capacity of fat gain over time, 5 as well as high weight gain during adult life.…”

Section: Discussionsupporting

confidence: 82%

“…6 An additive effect of the A?G polymorphism of the UCP1 gene and the Trp64Arg polymorphism of the b 3 AR gene on weight gain 6 or weight loss and weight maintenance 7 has also been reported, as well as a synergistic effect of these two polymorphisms contributing to lower basal metabolic rate. 8 The present study assessed the role of these two polymorphisms and their interaction as contributors to body weight changes in Finnish middle-aged, newly diagnosed type 2 diabetic patients, and in non-diabetic control subjects by using data from a 10 y follow-up study.…”

Section: Introductionmentioning

confidence: 99%

Synergistic effect of polymorphisms in uncoupling protein 1 and β3-adrenergic receptor genes on long-term body weight change in Finnish type 2 diabetic and non-diabetic control subjects

et al. 2000

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OBJECTIVE: To investigate the independent and combined effects of the Trp64Arg polymorphism of the b b 3 -adrenergic receptor (b b 3 AR) gene and the (À3826) A?G polymorphism of the uncoupling protein 1 (UCP1) gene on body weight change in type 2 diabetic and non-diabetic control subjects during a 10 y follow-up study. DESIGN: Controlled 10 y follow-up study with baseline, 5 and 10 y examinations. SUBJECTS: 70 newly diagnosed, middle-aged type 2 diabetic patients and 123 non-diabetic control subjects from eastern Finland. MEASUREMENTS: Anthropometric measurements, blood pressure, oral glucose tolerance test, plasma insulin, plasma C-peptide and HbA 1c . Genotypes by polymerase chain reaction followed by enzymatic digestion. RESULTS: No signi®cant differences were found in the frequencies of the two polymorphisms between diabetic and control subjects. The polymorphisms were not cross-sectionally or longitudinally associated with body weight or BMI in diabetic or control subjects. When the diabetic and control subjects were analysed together, the change in the mean body weight was signi®cantly greater among the subjects with both polymorphisms (n 11) than among those with no polymorphisms (n 103; change in weight 6.5 AE 2.5% vs À0.2 AE 0.8%, P 0.036, and change in Body Mass Index 8.5 AE 2.6% vs 2.0 AE 0.8%, P 0.060, mean AE s.e.m.). CONCLUSIONS: The simultaneous existence of the two polymorphisms was associated with a tendency to gain weight suggesting a synergistic effect of these polymorphisms on body weight gain.

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“…There are also signi®cant interactions between the genes for UCP-1 and the b 3 -adrenergic receptor. Synergistic effects of (A(À3826)G) in UCP-1 and Trp64Arg in b 3 -adrenoceptor on resting metabolic rate 27 and on changes in body weight 28,29 have been reported. However no relationship between the UCP-1 polymorphism and obesity was found in a Swedish population.…”

Section: Uncoupling Proteinsmentioning

confidence: 99%

Hunting for human obesity genes? Look in the adipose tissue!

Arner

2000

Int J Obes

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Synergistic effect of polymorphisms in uncoupling protein 1 and β 3 -adrenergic receptor genes on basal metabolic rate in obese Finns

Cited by 98 publications

References 24 publications

Synergistic effect of polymorphisms of uncoupling protein 1 and β3-adrenergic receptor genes on autonomic nervous system activity

Synergistic effect of polymorphisms of uncoupling protein 1 and β3-adrenergic receptor genes on autonomic nervous system activity

Synergistic effect of polymorphisms in uncoupling protein 1 and β3-adrenergic receptor genes on long-term body weight change in Finnish type 2 diabetic and non-diabetic control subjects

Hunting for human obesity genes? Look in the adipose tissue!

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