Synergistic effect of PAK and Hippo pathway inhibitor combination in NF2-deficient Schwannoma
Dorothy Benton,
Hoi Yee Chow,
Sofiia Karchugina
et al.
Abstract:Neurofibromatosis type 2 is a genetic disorder that results in the formation and progressive growth of schwannomas, ependymomas, and/or meningiomas. The NF2 gene encodes the Merlin protein, which links cell cortical elements to the actin cytoskeleton and regulates a number of key enzymes including Group I p21-activated kinases (PAKs), the Hippo-pathway kinase LATS, and mTORC. While PAK1 and PAK2 directly bind Merlin and transmit proliferation and survival signals when Merlin is mutated or absent, inhibition of… Show more
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