Synergistic effect of non-steroidal anti-inflammatory drugs (NSAIDs) on antibacterial activity of cefuroxime and chloramphenicol against methicillin-resistant Staphylococcus aureus

Chan, Elaine Wan Ling; Yee, Zong Yang; Raja, Iswara; Yap, Jeremy Kean Yi

doi:10.1016/j.jgar.2017.03.012

Cited by 91 publications

(82 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…aureus, with FICI = 0.5, what characterizes a synergistic effect between these drugs. Studies that assess the synergistic antibacterial activity of potential candidates for drug repositioning are already being explored, such as the one developed by Chan et al (2017) in Malaysia. These researchers have assessed the synergistic antibacterial activity of the non-steroidal anti-inflammatory drugs cefuroxime and chloramphenicol against methicillin-resistant and methicillin-susceptible S. aureus; however, MICs were evaluated in mg.mL -1 , and their concentrations were around one thousand times higher than the ones in the current study.…”

Section: Resultsmentioning

confidence: 99%

“…In light of this, repositioning is an attractive approach for studies that investigate the antimicrobial activities of psychotropics, local anaesthetics, tranquilizers, as well as cardiovascular, anti-histaminic and antiinflammatory drugs (Chan et al, 2017;Mandal et al, 2010;Rampelotto et al, 2018). The combination of drugs has been successfully used to treat MDR bacteria due to the synergistic effect achieved by the aggregation of their different action mechanisms.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synergistic effect of sertraline and disulfiram against multidrug resistant bacteria as a new alternative to drug repositioning

Serafin

Bottega

Foletto

et al. 2020

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

The repositioning of approved drugs is atopic of interest for the academy and the pharmaceutical industry. The synergistic combination of these drugs can be successful in the treatment of infections caused by resistant bacteria. This study aimed to assess the in vitro synergistic antibacterial activity of sertraline and disulfiram and their interaction with ciprofloxacin and sulfamethoxazole/trimethoprim. We determined the minimum inhibitory concentration, the minimum bactericidal concentration and the fractional inhibitory concentration index. Eighteen bacterial strains were used, being nine American Type Culture Collection reference strains and nine multidrug resistant clinical isolates. Synergy was detected between sertraline and disulfiram against a strain of Staphylococcus aureusATCC 25923 and a clinical isolate of S. aureus. When associated to sulfamethoxazole/trimethoprim and ciprofloxacin, sertraline and disulfiram showed eight synergistic events, which occurred against three different standard strains and two multidrug resistant clinical isolates. When the minimum bactericidal concentration was determined, the bactericidal activity of sertraline was enhanced with disulfiram. Our results suggest that these drugs, widely used to treat depression and chronic alcoholism, have antibacterial potential individually, in association, and combined with antimicrobials, what makes their repositioning a promising therapeutic alternative for the effective treatment of infections caused by multidrug resistant bacteria.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synergistic effect of sertraline and disulfiram against multidrug resistant bacteria as a new alternative to drug repositioning

Serafin

Bottega

Foletto

et al. 2020

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

show abstract

“…A atividade antibacteriana de diversos fármacos pertencentes à classe dos anti-inflamatórios não esteroides (AINES) já foi relatada 10,11 , além de sua conhecida ação frente a parasitas e fungos 10,[12][13][14][15] , o que torna essa classe de medicamentos uma alternativa promissora para o tratamento de infecções ocasionadas por esses microrganismos.…”

Section: Introductionunclassified

“…Já com relação a sua atividade antifúngica, AAS foi efetivo frente a Candida albicans, C. guilliermondii, C. kefyr, C. glabrata e C. parapsilosis 10,12 , além de inibir o crescimento do fungo Chaetomium globosum 17,18,19 .…”

Section: Introductionunclassified

Avaliação da atividade antibacteriana in vitro do medicamento ácido acetilsalicílico

Mainardi

Foletto²,

Marion³

et al. 2019

Saúde (Sta. Maria)

View full text Add to dashboard Cite

Objetivo: Avaliar a atividade antibacteriana do anti-inflamatório ácido acetilsalicílico (AAS) frente seis cepas bacterianas padrão de referência American Type Culture Collection (ATCC) e 41 isolados clínicos multidroga resistentes (MDR). Métodos: A atividade antibacteriana do medicamento foi determinada através da concentração inibitória mínima (CIM) obtida frente às cepas bacterianas. Resultados: AAS demonstrou atividade antibacteriana tanto frente a cepas Gram negativas (GN) como Gram positivas (GP), apresentando, frente a maioria das cepas testadas, CIM de 1024 µg/mL e 2048 µg/mL. Frente a um isolado clínico de Acinetobacter baumannii MDR, apresentou CIM de 512 µg/mL. AAS demonstrou atividade antibacteriana frente a microrganismos altamente resistentes. Conclusão: Nossos resultados permitem inferir que o medicamento AAS apresenta potencial atividade antibacteriana frente às cepas MDR testadas, porém estudos complementares devem ser realizados a fim de identificar seu mecanismo de ação na inibição bacteriana. Testes de sinergismos também são aconselhados com o objetivo de avaliar a associação do AAS com antibacterianos já utilizados na clínica, visto que sua atividade pode ser potencializada.

show abstract

“…On the other hand, because of emerging of new strains of microorganisms and resistance of microbes to current antibacterial agents, new antibacterial agents needed to be synthesized . N-(2,6-dimethyl phenyl) acetamide 1 had antibacterial activity (Hamad et al, 2017) and NSAIDs had been reported to possess antibacterial activity and they are known as non-antibiotics (Al-janabi, 2010, Yin et al, 2014 and co-administration of NSAIDs with antibiotics showed synergistic effect (Chan et al, 2017) and decrease the severity of colonic damage by counteracting the NSAID-induced fall in colonic microcirculation and bacterial translocation to extra-intestinal organs (Zwolinska-Wcislo et al, 2011). The ester linkage in the newly synthesized prodrugs 3a-f will be hydrolyzed by esterase enzyme to release the parent NSAID 2a-f and N-(2,6-dimethyl phenyl) acetamide 1.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Antibacterial Activity of Novel Mutual Non-Steroidal Anti-inflammatory Prodrugs

hamadameen

Ameen

2019

ZJPAS

View full text Add to dashboard Cite

Non steroidal anti-inflammatory drugs (NSAIDs) are among the most used analgesic and anti-inflammatory drugs. However inhibition of cyclooxygenase1 and acidic groups such as carboxylic groups in most NSAIDs cause gastrointestinal (GI) side effects. Therefore masking the acidic groups till it pass through the GI tract will decrease the direct GI side effects and because N-(2,6-dimethylphenyl)-acetamide 1 also has anti-inflammatory activity so the synthesized ester prodrugs might act as mutual prodrugs. Moreover, because of emerging of new strains of bacteria and resistance of bacteria to the available antibacterial agents, new antibacterial agents are needed. The NSAIDs have antibacterial activity and N-(2,6-dimethylphenyl) acetamide 1 also has antibacterial activity so binding of these molecules with each other might give more potent antibacterial agent. 2-Chloro-N-(2,6dimethyl phenyl) acetamide 1 was utilized to synthesize ester prodrug of various NSAIDs 2a-f. The 2-Chloro-N-(2,6dimethylphenyl)-acetamide 1 undergo substitution reaction at α position with various sodium carboxylate of NSAIDs 2a-f in DMSO. The constitution of the newly synthesized ester prodrugs of NSAIDs 3a-f had been confirmed on the basis of their IR, ¹H and ¹³C-NMR spectral data. All the synthesized ester prodrugs 3a-f were screened for their in vitro antibacterial activities against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 however, their antibacterial activity decreased compared with their starting 1 and 2a-f.

show abstract

Synergistic effect of non-steroidal anti-inflammatory drugs (NSAIDs) on antibacterial activity of cefuroxime and chloramphenicol against methicillin-resistant Staphylococcus aureus

Cited by 91 publications

References 18 publications

Synergistic effect of sertraline and disulfiram against multidrug resistant bacteria as a new alternative to drug repositioning

Synergistic effect of sertraline and disulfiram against multidrug resistant bacteria as a new alternative to drug repositioning

Avaliação da atividade antibacteriana in vitro do medicamento ácido acetilsalicílico

Synthesis, Characterization, and Antibacterial Activity of Novel Mutual Non-Steroidal Anti-inflammatory Prodrugs

Contact Info

Product

Resources

About