Synergistic effect of methionine encephalin (MENK) combined with pidotimod(PTD) on the maturation of murine dendritic cells (DCs)

Meng, Yiming; wang, qiushi; Zhang, Zhenjie; Wang, Enhua; Plotnikoff, Nicollas P.; Shan, Fengping

doi:10.4161/hv.23137

Cited by 19 publications

(5 citation statements)

References 67 publications

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“…[15][16][17][18][19][20][21] Our documented record showed that considerable work of approaches with MENK on its impact on immune cells in vitro and in vivo has been done in our laboratory. [7][8][9][10][11] There are predominantly mu, delta, and kappa-3 types of opioid receptors. The mu receptor is responsible for addiction and pain, while kappa and delta are responsible for immunity according to published data.…”

Section: Discussionmentioning

confidence: 99%

“…2 The data from both early documented studies [3][4][5] and published results in our laboratory indicated that MENK at suitable range of concentrations could enhance activity of various types of immune cells, like: augmenting interactions between dendritic cells (DCs) and CD4+T cells, induction of phenotypic and functional maturation of DCs with increased antigen presentation, improvement of antitumor activity of DCs loaded with antigen, induction of macrophage polarization to the M1 phenotype in mouse model, eliciting CD8+T cell cytotoxicity, upregulating the secretion of cytokines such as IL-2, IL-12, IFN-γ, TNF-α, increasing the release of hydrogen peroxide and nitric oxide and stimulation of lymphocyte subpopulations in normal human donors. [6][7][8][9][10][11][12] In addition, there have been studies indicating that MENK could inhibit tumor growth. 13,14 However, so far there is little approach to the influence on lymphocyte subpopulations in large samples of cancer patients by MENK.…”

Section: Introductionmentioning

confidence: 99%

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Methionine enkephalin (MENK) improves lymphocyte subpopulations in human peripheral blood of 50 cancer patients by inhibiting regulatory T cells (Tregs)

Wang

Gao

Yuan

et al. 2014

Human Vaccines & Immunotherapeutics

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Methionine enkephalin (MENK) improves lymphocyte subpopulations in human peripheral blood of 50 cancer patients by inhibiting regulatory T cells (Tregs)

Wang

Gao

Yuan

et al. 2014

Human Vaccines & Immunotherapeutics

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“…Moreover, enkephalins include methionine enkephalins (MENK) and leucine enkephalins (LENK). The regulatory effect of MENK on the immune system is reflected in many aspects, such as regulating macrophage phagocytosis and phenotypic polarization [ 60 ], activating NK cells and enhancing their activity [ 61 , 62 , 63 , 64 ], promoting the maturation of dendritic cells within a certain concentration range [ 65 ], regulating the growth of B lymphocytes bi-directionally [ 66 ] and affecting the release of cytokines [ 67 ]. Furthermore, studies on the mechanism of acupuncture’s effect on the immune activity of NK cells have found that LENK can increase the lethality of NK cells [ 59 ].…”

Section: Mechanisms Of Acupuncture On the Neuro-endocrine-immune Networkmentioning

confidence: 99%

Research Progress on the Mechanism of the Acupuncture Regulating Neuro-Endocrine-Immune Network System

Cui

Song

Jin

et al. 2021

Veterinary Sciences

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As one of the conventional treatment methods, acupuncture is an indispensable component of Traditional Chinese Medicine. Currently, acupuncture has been partly accepted throughout the world, but the mechanism of acupuncture is still unclear. Since the theory of the neuro-endocrine-immune network was put forward, new insights have been brought into the understanding of the mechanism of acupuncture. Studies have proven that acupuncture is a mechanical stimulus that can activate local cell functions and neuroreceptors. It also regulates the release of related biomolecules (peptide hormones, lipid hormones, neuromodulators and neurotransmitters, and other small and large biomolecules) in the microenvironment, where they can affect each other and further activate the neuroendocrine-immune network to achieve holistic regulation. Recently, growing efforts have been made in the research on the mechanism of acupuncture. Some researchers have transitioned from studying the mechanism of acupuncture as a single linear pathway to using systems approaches, including metabolomics, genomics, proteomics and biological pathway analysis. This review summarizes the research progress on the neuro-endocrine-immune network related mechanism of acupuncture and discusses its current challenges and future directions.

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“…However, these categories may overlap depending on the bacterial species, dosing, growth conditions, etc., and the distinction offers little relevance in clinical practice. 22,23 Certain antibiotics, such as nitrofurantoin, also employ a multifaceted mode of action. Nitrofurantoin is effective against common UTI pathogens and resistance is low (79-92% cure rates).…”

Section: Importance Of Local Epidemiologymentioning

confidence: 99%

Appropriate use of antibiotics: an unmet need

Romo

Quirós²

2019

Therapeutic Advances in Urology

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Increasing bacterial resistance combined with a steady decline in the discovery of new antibiotics has resulted in a global healthcare crisis. Overuse of antibiotics, for example, in the poultry and cattle industry, and misuse and improper prescription of antibiotics are leading causes of multidrug resistance (MDR). The increasing use of antibiotics, particularly in developing countries, is a big concern for antibiotic resistance and can cause other health threats such as increased risk of recurrent infections and increased risk of cardiovascular death with chronic use of macrolides. Carbapenems are the last line of defense in many cases of resistant infection, but trends show that resistance against these agents is also increasing. This narrative review is based on relevant literature according to the experience and expertise of the authors and presents an overview of the current knowledge on antibiotic resistance, the key driving factors, and possible strategies to tackle antibiotic resistance. Collectively, studies show that hospital-wide antibiotic stewardship programs are effective in decreasing the spread of antibacterial resistance. As resistance varies according to local patterns of use, it is essential to observe the epidemiology at both a regional and an institutional level. Furthermore, adaptation of clinical guidelines is necessary, particularly for inpatient care. Future guidelines should include a justification step for continued treatment of antibiotic treatments and criteria for selection of antibiotics at the start of treatment. Nonantibiotic prevention strategies can limit infections and should also be considered in treatment plans. Vaccines against MDR organisms have shown some efficacy in phase II trials in critical care patients. Nonimmunogenic and microbiologic treatment options such as fecal transplants may be particularly important for elderly and immune-compromised patients.

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Synergistic effect of methionine encephalin (MENK) combined with pidotimod(PTD) on the maturation of murine dendritic cells (DCs)

Cited by 19 publications

References 67 publications

Methionine enkephalin (MENK) improves lymphocyte subpopulations in human peripheral blood of 50 cancer patients by inhibiting regulatory T cells (Tregs)

Methionine enkephalin (MENK) improves lymphocyte subpopulations in human peripheral blood of 50 cancer patients by inhibiting regulatory T cells (Tregs)

Research Progress on the Mechanism of the Acupuncture Regulating Neuro-Endocrine-Immune Network System

Appropriate use of antibiotics: an unmet need

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