Synergistic Effect of Lipoprotein-Associated Phospholipase A2 with Classical Risk Factors on Coronary Heart Disease: A Multi-Ethnic Study in China

Abstract

Aims: We evaluated the synergistic effect of lipoprotein-associated phospholipase A2 (Lp-PLA2) in association with classical risk factors in predicting coronary heart disease (CHD) and demonstrated the diagnostic value of Lp-PLA2 for predicting coronary stenotic lesions in subjects with CHD. Methods: Blood samples were acquired from 911 consecutive adult subjects (662 males and 249 females) from 11 ethnic groups. Lp-PLA2 plasma levels were detected using a commercially available turbidimetric immunoassay (TIA). CHD in patients was confirmed using coronary angiography, and the severity of coronary atherosclerosis was assessed using the Gensini scoring system. Results: A binary logistic regression was performed to analyse the relationships between Lp-PLA2 and other risk factors. A multivariate logistic regression analysis revealed that Lp-PLA2 levels were significantly associated with CHD (OR, 1.882; 95% CI, 1.369-2.587, p=0.000).The area under the receiver operating characteristic curve for Lp-PLA2 was 0.589 (95%CI, 0.549-0.629, p=0.000).The synergism between Lp-PLA2 and other risk factors was also investigated. The proportion of CHD attributable to the interaction between Lp-PLA2 and age was as high as 64%. Conclusions: Lp-PLA2 levels in human plasma were positively associated with the severity of CHD, and there was a clear positive interaction between Lp-PLA2 and classical risk factors in predicting CHD.

Lipoprotein-Associated Phospholipase A2 Activity Level may be complementary to Cardiactroponin I as a Biomarker for Acute Myocardial Infarction in Chinese Patients with Chest Pain

“…Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a pro-inflammatory enzyme secreted by monocytes and macrophagocytes. Precious study has found that about 70% of Lp-PLA2 binds to low-density lipoprotein (LDL) particles and the residual 30% binds to high-density lipoprotein (HDL) particles (Ge et al 2016). Our study showed the positive correlation between Lp-PLA2 and LDL-C, not between Lp-PLA2 and HDL-C.…”

Elevated Lipoprotein-Associated Phospholipase A2 Independently Affects Age-Related Increases in Systolic Blood Pressure: A Nested Case-Control Study in a Prospective Korean Cohort

“…Finally, we could not demonstrate why Lp-PLA 2 activity only showed a correlation with an increase in systolic BP but not in diastolic BP. In addition to our study, several others have reported a positive association between Lp-PLA 2 activity and systolic BP [26][27][28]. To the best of our knowledge, the underlying mechanisms that explain why only systolic BP mostly correlates with Lp-PLA 2 activity have not been elucidated.…”

Lipoprotein-associated phospholipase A2 and oxidized low-density lipoprotein in young patients with acute coronary syndrome in China

“…However, there was a clear positive interaction between Lp-PLA2 and classical risk factors in predicting CAD, especially for age. The proportion of CAD attributable to the interaction between Lp-PLA2 and age was as high as 64% 19 . Therefore, the association between Lp-PLA2 and CAD observed in elderly patients may be different in young Chinese patients.…”