Synergistic effect of hypocrellin B and curcumin on photodynamic inactivation of <i>Staphylococcus aureus</i>

Li, Yali; Xu, Yi; Liao, Qiaoming; Xie, Min; Han, Tao; Wang, Huili

doi:10.1111/1751-7915.13734

Cited by 24 publications

(19 citation statements)

References 42 publications

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“…The combination of CUR and another natural PS, hypocrellin B, increased the photoinactivation of S. aureus compared with the photodynamic effect of each PS alone [32]. Bacterial cells showed alteration in their membrane integrity and the dual-PS-mediated aPDT also decontaminated apples with S. aureus [32]. The CUR-mediated aPDT was also effective in decontaminating food, reducing the number of S. aureus recovered from meat and fruit [33].…”

Section: Antibacterial Activitymentioning

confidence: 99%

Antimicrobial Activity of Curcumin in Nanoformulations: A Comprehensive Review

Trigo-Gutierrez

Vega-Chacón

Soares

et al. 2021

IJMS

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Curcumin (CUR) is a natural substance extracted from turmeric that has antimicrobial properties. Due to its ability to absorb light in the blue spectrum, CUR is also used as a photosensitizer (PS) in antimicrobial Photodynamic Therapy (aPDT). However, CUR is hydrophobic, unstable in solutions, and has low bioavailability, which hinders its clinical use. To circumvent these drawbacks, drug delivery systems (DDSs) have been used. In this review, we summarize the DDSs used to carry CUR and their antimicrobial effect against viruses, bacteria, and fungi, including drug-resistant strains and emergent pathogens such as SARS-CoV-2. The reviewed DDSs include colloidal (micelles, liposomes, nanoemulsions, cyclodextrins, chitosan, and other polymeric nanoparticles), metallic, and mesoporous particles, as well as graphene, quantum dots, and hybrid nanosystems such as films and hydrogels. Free (non-encapsulated) CUR and CUR loaded in DDSs have a broad-spectrum antimicrobial action when used alone or as a PS in aPDT. They also show low cytotoxicity, in vivo biocompatibility, and improved wound healing. Although there are several in vitro and some in vivo investigations describing the nanotechnological aspects and the potential antimicrobial application of CUR-loaded DDSs, clinical trials are not reported and further studies should translate this evidence to the clinical scenarios of infections.

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Section: Antibacterial Activitymentioning

confidence: 99%

Antimicrobial Activity of Curcumin in Nanoformulations: A Comprehensive Review

Trigo-Gutierrez

Vega-Chacón

Soares

et al. 2021

IJMS

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“…Bacterial growth can also be controlled using a new approach-photodynamic inactivation. Staphylococcus aureus growth was inhibited by the combination therapy of curcumin and hypocrellin B, where the photodynamic efficacy of hypocrellin B was potentiated by curcumin [75].…”

Section: Synergistic Effectsmentioning

confidence: 99%

Antimicrobial Potential of Curcumin: Therapeutic Potential and Challenges to Clinical Applications

et al. 2022

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Curcumin is a bioactive compound that is extracted from Curcuma longa and that is known for its antimicrobial properties. Curcuminoids are the main constituents of curcumin that exhibit antioxidant properties. It has a broad spectrum of antibacterial actions against a wide range of bacteria, even those resistant to antibiotics. Curcumin has been shown to be effective against the microorganisms that are responsible for surgical infections and implant-related bone infections, primarily Staphylococcus aureus and Escherichia coli. The efficacy of curcumin against Helicobacter pylori and Mycobacterium tuberculosis, alone or in combination with other classic antibiotics, is one of its most promising antibacterial effects. Curcumin is known to have antifungal action against numerous fungi that are responsible for a variety of infections, including dermatophytosis. Candidemia and candidiasis caused by Candida species have also been reported to be treated using curcumin. Life-threatening diseases and infections caused by viruses can be counteracted by curcumin, recognizing its antiviral potential. In combination therapy with other phytochemicals, curcumin shows synergistic effects, and this approach appears to be suitable for the eradication of antibiotic-resistant microbes and promising for achieving co-loaded antimicrobial pro-regenerative coatings for orthopedic implant biomaterials. Poor water solubility, low bioavailability, and rapid degradation are the main disadvantages of curcumin. The use of nanotechnologies for the delivery of curcumin could increase the prospects for its clinical application, mainly in orthopedics and other surgical scenarios. Curcumin-loaded nanoparticles revealed antimicrobial properties against S. aureus in periprosthetic joint infections.

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“…To solve this issue, Tortik et al 90 reported that PDI by using curcumin (50-100 μM) and blue light (λ = 435 nm) of S. aureus and other food-borne microbes could be an effective way to make food stuffs microbe free. 91,92 This study may be further extended in which antibacterial activity of curcumin and chemical food preservatives (like benzoic acid, nitrites, sodium benzoate, sulfites, potassium sorbate, and sodium sorbate) may be tested together in future food processing research by mixing the natural and chemical preservatives in various proportions, thereby reducing the actual amount of chemical preservatives required in food processing industry. Ultrasound finds good application in the field of medicine and biology in recent years and has multiple advantages like low cost, safety and convenience of operation, and intense penetration in biological tissue.…”

Section: Curcumin and Its Various Nanoformulations-mediated Inhibitio...mentioning

confidence: 99%

“…In a nutshell and precisely, it can be inferred that nanocurcumin/nanocomposites and curcumin exhibit efficient anti‐ P. aeruginosa and antibiofilm activity by inhibiting the QS system, retarding release of components for biofilm formation, biofilm disruption, ROS‐mediated bacterial membrane, and ultrastructure damage 51–66,71–78 . Similarly, MRSA and MDR‐ S. aureus growth and biofilm can be effectively inhibited with nanocurcumin/nanocomposites and curcumin along with antibiotics, blue light‐mediated PDI, cell penetrating peptide, and so on, that generate singlet oxygen and other ROS, thereby causing bacterial membrane damage and cytoplasmic leakage 79–102 . Curcumin nanocomplex aerosols and crude curcumin (along with blue LED light‐activated EDTA) have the potential to inhibit B. cepacia growth by mechanism that includes bacterial DNA and protein damage and intracellular content leakage 103–109 .…”

Section: Mechanism Of Antibacterial Activity Of Curcumin Its Essentia...mentioning

confidence: 99%

Antibacterial activity of curcumin and its essential nanoformulations against some clinically important bacterial pathogens: A comprehensive review

Shome

Talukdar

Upadhyaya

2021

Biotech and App Biochem

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Multidrug‐resistant bacterial infections can kill 700,000 individuals globally each year and is considered among the top 10 global health threats faced by humanity as the arsenal of antibiotics is becoming dry and alternate antibacterial molecule is in demand. Nanoparticles of curcumin exhibit appreciable broad‐spectrum antibacterial activity using unique and novel mechanisms and thus the process deserves to be reviewed and further researched to clearly understand the mechanisms. Based on the antibiotic resistance, infection, and virulence potential, a list of clinically important bacteria was prepared after extensive literature survey and all recent reports on the antibacterial activity of curcumin and its nanoformulations as well as their mechanism of antibacterial action have been reviewed. Curcumin, nanocurcumin, and its nanocomposites with improved aqueous solubility and bioavailability are very potential, reliable, safe, and sustainable antibacterial molecule against clinically important bacterial species that uses multitarget mechanism such as inactivation of antioxidant enzyme, reactive oxygen species‐mediated cellular damage, and inhibition of acyl‐homoserine‐lactone synthase necessary for quorum sensing and biofilm formation, thereby bypassing the mechanisms of bacterial antibiotic resistance. Nanoformulations of curcumin can thus be considered as a potential and sustainable antibacterial drug candidate to address the issue of antibiotic resistance.

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Synergistic effect of hypocrellin B and curcumin on photodynamic inactivation of Staphylococcus aureus

Cited by 24 publications

References 42 publications

Antimicrobial Activity of Curcumin in Nanoformulations: A Comprehensive Review

Antimicrobial Activity of Curcumin in Nanoformulations: A Comprehensive Review

Antimicrobial Potential of Curcumin: Therapeutic Potential and Challenges to Clinical Applications

Antibacterial activity of curcumin and its essential nanoformulations against some clinically important bacterial pathogens: A comprehensive review

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