Synergistic Effect of Green Tea Catechins on Cell Growth and Apoptosis Induction in Gastric Carcinoma Cells

Horie, Nobutaka; Hirabayashi, N; Takahashi, Yoshie; Miyauchi, Yuko; Taguchi, Hiroko; Takeishi, Keiichi

doi:10.1248/bpb.28.574

Cited by 71 publications

(56 citation statements)

References 13 publications

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“…Saha et al reported that the combination of curcumin with epicatechin significantly increased the inhibition of cell growth compared with curcumin or epicatechin alone. Epicatechin may enhance the incorporation of curcumin into human lung cancer cell lines PC-9 and A549 (27). It is hypothesized that two above mentioned actions participated a chemosensitive effect of epicatechin on cytotoxicity induced by BLM.…”

Section: Discussionmentioning

confidence: 99%

Epicatechin enhances anti-proliferative effect of bleomycin in ovarian cancer cell

2013

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Background: Bleomycin (BLM) is an anti-cancer drug widely used in the treatment of cancer. BLM causes several side effects related to DNA and cellular damage. The aim of this study was investigated the effects of tea polyphenol epicatechin on anti-proliferative effects induced by bleomycin in human normal skin and human ovarian cancer cells. Materials and Methods: Human ovarian cancer cell (SKOV-3) and human nonmalignant fibroblast cell (HFFF2) were treated with epicatechin at various concentrations (10, 25 and 50 µM) and BLM alone and with their combinations, further their effects on cell viability were evaluated. Results: The combined treatment of epicatechin with BLM enhanced significantly inhibition of cell growth in comparison to BLM alone in cancer cell. Epicatechin enhanced significantly cytotoxicity induced by BLM with 83% at dose 50 µM, while it was 92% in BLM-treated cells. Epicatechin was not showed any cytotoxicity on HFFF2 cells. Conclusion: Study suggests that epicatechin chemosensitize the ovarian cancer cell to BLM-induced growth inhibition without any toxicity on normal cell.

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Section: Discussionmentioning

confidence: 99%

Epicatechin enhances anti-proliferative effect of bleomycin in ovarian cancer cell

2013

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“…Catechins, its major component, have been demonstrated to have anticarcinogenic activities. [18][19][20][21] Horie et al 19) reported a synergistic effect of gtreen tea catechins on cell growth and apoptosis induction in gastric carcinoma cells. They suggest that the synergism may involve the extracellular production of reactive oxygen species.…”

Section: Discussionmentioning

confidence: 99%

Anti-ulcer Effect of Tea Catechin in Rats

Hamaishi

Kojima

Ito

2006

Biological & Pharmaceutical Bulletin

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“…Interestingly, a synergistic efect has been reported to induce apoptosis by combination of drugs and/or natural phenolics. In this line, (-)-epicatechin (EC) showed a major synergistic efect on the induction of apoptosis in gastric cancer MKN-45 cells treated with epigallocatechin-3-gallate [47]. Similarly, the combination of curcumin with (-)-epicatechin increased the inhibition of cell growth as compared to curcumin or EC alone, as well as the apoptosis rate and the expression of related genes to the programmed cell death, such as growth arrest DNA damage 153/45 (GADD153/45) in PC-9…”

Section: Phenolic Compounds -Biological Activitymentioning

confidence: 95%

Health Benefits of Phenolic Compounds Against Cancers

Basli¹,

Belkacem²,

Amrani³

2017

Phenolic Compounds - Biological Activity

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Phenolic compounds are the biggest group of phytochemicals, and many of them have been found in plant-based foods. Polyphenol-rich diets have been linked to many health beneits including cancer. The potential anti-carcinogenic mechanisms of action that have been so far identiied for phenolic compounds, as well as the feasibility reports occurred in vivo. In general terms, under the oxidative stress, polyphenols could act in those cellular mechanisms by participating in the modulation of the redox status and on multiple key elements in intracellular signal transduction pathways related to cell proliferation, diferentiation, apoptosis, inlammation, angiogenesis and metastasis. A protective role of polyphenols against carcinogenesis is supported by many studies carried out on animal models and diferent mechanisms of action have been proposed to explain such protective efects. Studies performed in animals have demonstrated that phenolic components can prevent and/or slow down the initiation-progression of diferent types of cancers. They act through the regulation of cell signal transduction and gene expression and exhibit either up or down regulation of genes controlling tumor development.

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Synergistic Effect of Green Tea Catechins on Cell Growth and Apoptosis Induction in Gastric Carcinoma Cells

Cited by 71 publications

References 13 publications

Epicatechin enhances anti-proliferative effect of bleomycin in ovarian cancer cell

Epicatechin enhances anti-proliferative effect of bleomycin in ovarian cancer cell

Anti-ulcer Effect of Tea Catechin in Rats

Health Benefits of Phenolic Compounds Against Cancers

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