Synergistic Effect of Graphene Oxide Coated Nanotised Apigenin with Paclitaxel (GO-NA/PTX): A ROS Dependent Mitochondrial Mediated Apoptosis in Ovarian Cancer

Pal, Mahendra; Dwivedi, Ashish; Goyal, Shruti; Dwivedi, Vinay; Pathak, Anurag; Kumar, Vinod; Sankhwar, Pushp Lata; Ray, Ratan Singh

doi:10.2174/1871520617666170425094549

Cited by 17 publications

(14 citation statements)

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“…Furthermore, apigenin downregulated Mcl-1, disturbed mitochondria activity and induced cell death, which may be the potential mechanism via which apigenin targets malignancies. Mitochondria-modulated cell death contributes to OC and resistance to cisplatin (29). It is widely recognized that changes in Bax and Bcl-2 expression levels regulate matrix metalloproteinases (30,31).…”

Section: Discussionmentioning

confidence: 99%

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Apigenin induces apoptosis and counteracts cisplatin‑induced chemoresistance via Mcl‑1 in ovarian cancer cells

Ding

Yao

et al. 2020

Exp Ther Med

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Ovarian cancer (OC) is one of the prominent causes of mortality in female patients diagnosed with gynecologic malignancies. While it has previously been demonstrated that apigenin inhibits cell growth in colon and breast cancer cells, the effect of apigenin in OC cells is not fully understood. Therefore, the aim of the present study was to investigate the impact of apigenin on cell death and resistance to cisplatin in OC cells. It was found that apigenin inhibited proliferation, hindered cell cycle progression and promoted SKOV3 cell apoptosis. Moreover, these effects were also observed in cisplatin-resistant SKOV3/DDP cells. Furthermore, apigenin reduced the mitochondrial transmembrane potential, and elevated the ratios of cleaved caspase-3/caspase-3 and Bax/Bcl-2 in the two cell types. Reverse transcription-quantitative PCR and western blotting results demonstrated that apigenin significantly downregulated Mcl-1 at the transcriptional and translational levels in SKOV3 and SKOV3/DDP cells, which was responsible for its cytotoxic functions and chemosensitizing effects. Collectively, the present results identified the impact of apigenin on OC cell death and resistance to cisplatin, and the potential molecular mechanisms. However, additional studies are required to further elucidate the underlying mechanisms.

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Section: Discussionmentioning

confidence: 99%

“…Mitochondria-modulated cell death contributes to OC and resistance to cisplatin ( 29 ). It is widely recognized that changes in Bax and Bcl-2 expression levels regulate matrix metalloproteinases ( 30 , 31 ).…”

Section: Discussionmentioning

confidence: 99%

Apigenin induces apoptosis and counteracts cisplatin‑induced chemoresistance via Mcl‑1 in ovarian cancer cells

Ding

Yao

et al. 2020

Exp Ther Med

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“…Early Detection : A number of studies have confirmed that RNA biomarkers have important clinical implications as the early indicator of cancer . This is mostly due to the fact that during the early development of tumor cells, they release significant amounts of RNA into the blood circulation and mostly being upregulated.…”

Section: Diagnostic and Prognostic Roles Of Rnamentioning

confidence: 99%

RNA Biomarkers: Diagnostic and Prognostic Potentials and Recent Developments of Electrochemical Biosensors

et al. 2017

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Ribonucleic acids (RNAs) are considered as effective and minimally invasive biomarkers for disease diagnosis and prognosis due to their critical role in the regulation of different cellular processes. Over the past several years, the rapid progress in RNA biomarker research has resulted in the development of a large number of high‐performance RNA‐detection methods. Most of these methods are based on molecular‐biology techniques such as quantitative reverse transcription polymerase chain reaction (RT‐qPCR), microarrays, and RNA sequencing. In recent years, considerable attention has also been dedicated to developing RNA biosensors, exploiting micro‐ and nanofabrication technologies, and various readout strategies, including electrochemical and optical transducers. Here, the recent developments of RNA biosensors are concisely reviewed with a special emphasis on electrochemical‐detection approaches. The following points are also highlighted: i) all the types of clinically relevant RNAs (mRNAs, miRNAs, lncRNAs) and their diagnostic and prognostic potential in cancer are outlined, ii) major challenges associated with current techniques are identified, followed by a critical analysis of how these challenges have been addressed by different biosensing approaches, and iii) the current requirements that still need to be met for effective screening of RNA biomarkers in both research and clinical settings.

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“…This may lead to cancer development or treatment resistance [12]. The identification of death inducing miRNAs might influence the outcome of treatment therapies [13], overcome treatment resistances and help to cure cancer (CA).…”

Section: Introductionmentioning

confidence: 99%

Induction of apoptosis in ovarian cancer cells by miR-493-3p directly targeting AKT2, STK38L, HMGA2, ETS1 and E2F5

Kleemann¹,

Schneider²,

Unger³

et al. 2018

Cell. Mol. Life Sci.

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The results published here are based upon data generated by the TCGA Research Network. In addition, the authors are grateful to Dr. Anne-Marie Mes-Masson (Centre Hospitalier de l´Université de Montréal, Canada) for providing us with the TOV21G and TOV112D cells as well as to Alex Shu-Wing Ng (Department of Obstetrics, Gynecology and Reproductive Biology, the Brigham and Women's Hospital, Boston, USA) for the HOSE 2170 cells. The OVCAR3, A2780 and A2780-cis cells were kindly provided by Verena Jendrossek (Institute of Cell Biology (Cancer Research),

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Synergistic Effect of Graphene Oxide Coated Nanotised Apigenin with Paclitaxel (GO-NA/PTX): A ROS Dependent Mitochondrial Mediated Apoptosis in Ovarian Cancer

Abstract: The combination of PTX with GO-NA produces synergistic effects in SKOV-3 cells via the modulation of pro and anti-apoptotic gene and may reduce side effects of PTX.

Cited by 17 publications

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Apigenin induces apoptosis and counteracts cisplatin‑induced chemoresistance via Mcl‑1 in ovarian cancer cells

Apigenin induces apoptosis and counteracts cisplatin‑induced chemoresistance via Mcl‑1 in ovarian cancer cells

RNA Biomarkers: Diagnostic and Prognostic Potentials and Recent Developments of Electrochemical Biosensors

Induction of apoptosis in ovarian cancer cells by miR-493-3p directly targeting AKT2, STK38L, HMGA2, ETS1 and E2F5

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