Synergistic effect of glucocorticoids and androgens on the biosynthesis of a sex-dependent protein in the male rat

Age-Dependent Changes in the Excretion of Urinary Proteins by the Rat

“…Thus males at puberty or 40 days of age produce a specific sex-dependent protein called < X 2u-globulin [1][2][3][4]. The hepatic biosynthesis of this protein is under the control of androgens [4,5] and glucocorticoids [5], In the young male, the ot2u represents 25-30% of the total urinary pro tein (TUP) [6]. As the rat ages, the spontane ous degeneration of the kidney, called chronic or progressive glomerulonephrosis [7] leads to an increased excretion of TUP [8][9][10][11][12], In a study relating morphologic changes with age, Hirolcawa [13] demonstrated a fusion of podocytes and a glomerular thickening as early as 3 months of age.…”

A new approach for assessment of narcotic physical dependence using urinary sex-dependent low molecular weight proteins in male rats.

“…Moreover, the decreased RNA poly merase activity did not recover to the control level within 10 days following morphine withdrawal, in spite of the fact that the decreased LMWP excretion was restored to normal within 7 days after the withdrawal (1). The hepatic synthesis of a2u-globulin in male rats has been reported to be under the complex control of such hormones as andro gens, glucocorticoids, thyroid hormones, and pituitary growth hormone (24)(25)(26)(27). Therefore, it is necessary to investigate the relationship between the hormonal action and inhibition of hepatic LMWP synthesis by narcotics since effects of narcotics and endogenous opioid peptides on endocrine functions have been well known (28).…”

“…Accepted October 25,1982 Abstract-Attempts have been made to examine the relationship between urinary excretion of sex-dependent low molecular weight proteins found only in male rats (LMWP) and morphine physical dependence. Chronic administration of morphine produced a dose-related decrease in urinary LMWP excretion, which was correlated to the intensity of withdrawal signs including body weight loss and abnormal behaviors recognized after naloxone challenge.…”

Effects of whole-body $gamma$-irradiation on the biosynthesis of certain serum proteins. Progress report, September 1, 1972--December 31, 1973

“…This protein is synthesized in the liver, secreted into the blood stream, concentrated in the kidneys, and excreted in the urine. Its synthesis is under the synergistic control of androgens and glucocorticoids (3)(4)(5)(6)(7)(8)(9)(10)(11).…”