Synergistic Effect of Frog Skin Antimicrobial Peptides in Combination with Antibiotics Against Multi host Gram-Negative Pathogens

Lekshmipriya, P.; Vineethkumar, T. V.; Joseph, Joelin; Asha, R.; Thomas, Sabu; George, Sanil

doi:10.1007/s10989-021-10189-w

Cited by 5 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Synergy measurement and FIC index (FICI) determination was conducted as per recent reports. 46,47 We obtained the FIC index value of 0.3125 for S. aureus cells and 0.5 for E. coli (ATCC 25922) cells (see Table 3). These indices signify a synergistic interaction between R8 and isopropyl compound when individual drugs are directly mixed in solution.…”

Section: Checkerboard Assay and Fic Determinationmentioning

confidence: 99%

Emergent antibacterial activity ofN-(thiazol-2-yl)benzenesulfonamides in conjunction with cell-penetrating octaarginine

et al. 2021

View full text Add to dashboard Cite

show abstract

Section: Checkerboard Assay and Fic Determinationmentioning

confidence: 99%

Emergent antibacterial activity ofN-(thiazol-2-yl)benzenesulfonamides in conjunction with cell-penetrating octaarginine

et al. 2021

View full text Add to dashboard Cite

show abstract

“…7 As a result, well-known methods such as modifying physiochemical features, amidation or acylation, and adding nonnatural amino acids as well as newer techniques such as molecular targeting AMPs, liposomal formulation, drug delivery system, and combinatorial therapy of peptide-antibiotic combinations might be used to circumvent these flaws. 8,9 AMPs can be used synergistically with conventional antibiotics. 10 Multidrug resistant bacterial infections have been successfully treated with peptide and antibiotics combination therapy, with minimal harmful side effects.…”

Section: Introductionmentioning

confidence: 99%

Synergistic effects of short peptides and antibiotics against bacterial and fungal strains

Sharma

Bisht

2022

Journal of Peptide Science

View full text Add to dashboard Cite

There is a rising tide of concern about the antibiotic resistance issue. To reduce the possibility of antibiotic‐resistant infections, a new generation of antimicrobials must be developed. Antimicrobial peptides are potential alternatives to antibiotics that can be used alone or together with conventional antibiotics to combat antimicrobial resistance. In this work, lead compounds LP‐23, DP‐23, SA4, and SPO from previously published studies were synthesized by solid‐phase peptide synthesis and their antimicrobial evaluation was carried out against various bacterial and fungal strains. Peptide combinations with antibiotics were evaluated by using the checkerboard method and their minimal inhibitory concentration (MIC) in combination was calculated by using the fractional inhibitory concentration (FIC) index. Cytotoxicity evaluations of these peptides further confirmed their selectivity toward microbial cells. Based on the FIC values, LP‐23, DP‐23, and SPO demonstrated synergy in combination with gentamicin against a gentamicin‐resistant clinical isolate of Escherichia coli. For Staphylococcus aureus, Escherichia coli, and Salmonella typhimurium, seven combinations exhibited synergistic effects between peptide/peptoids and the tested antibiotics. Additionally, almost all the combinations of peptides/peptoids with amphotericin B and fluconazole also showed effective synergy against Aspergillus niger and Aspergillus flavus. The synergy found between LP‐23, DP‐23, SA4, and SPO with the selected antibiotics may have the potential to be used as a combination therapy against various microbial infections.

show abstract

Cloning, recombinant expression, purification, and functional characterization of AGAAN antibacterial peptide

et al. 2023

View full text Add to dashboard Cite

Synergistic Effect of Frog Skin Antimicrobial Peptides in Combination with Antibiotics Against Multi host Gram-Negative Pathogens

Cited by 5 publications

References 37 publications

Emergent antibacterial activity ofN-(thiazol-2-yl)benzenesulfonamides in conjunction with cell-penetrating octaarginine

Emergent antibacterial activity ofN-(thiazol-2-yl)benzenesulfonamides in conjunction with cell-penetrating octaarginine

Synergistic effects of short peptides and antibiotics against bacterial and fungal strains

Cloning, recombinant expression, purification, and functional characterization of AGAAN antibacterial peptide

Contact Info

Product

Resources

About