Synergistic effect of fosfomycin and arbekacin on a methicillin-resistant Staphylococcus aureus-induced biofilm in a rat model

Morikawa, Keiko; Nonaka, Mitsuko; Yoshikawa, Yuka; Torii, Ikuko

doi:10.1016/j.ijantimicag.2004.07.015

Cited by 19 publications

(18 citation statements)

References 26 publications

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“…Experimental studies in rats with biofilms induced by S. aureus and Pseudomonas aeruginosa have shown that FOF induces changes in biofilm structure and the inflammatory response (9,16,17). Further, it was shown that FOF increases the penetration of concomitant antimicrobial agents into biofilms, resulting in increased eradication of embedded bacteria (9,(16)(17)(18). Likewise, an in vitro study very recently showed that FOF enhances the activities of linezolid, minocycline, vancomycin, and teicoplanin against planktonic or biofilm-embedded MRSA organisms (10).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Fosfomycin Compared to Vancomycin in Treatment of Implant-Associated Chronic Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats

Poeppl

Lingscheid

Bernitzky

et al. 2014

Antimicrob Agents Chemother

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. In the fosfomycin group, MRSA was detectable in 2 out of 10 (20%) animals (3.42 ؋ 10 2 and 1.51 ؋ 10 3 CFU/g of bone). Vancomycin was superior to the no-drug control (P ‫؍‬ 0.002), and fosfomycin was superior to the no-drug control and vancomycin (P < 0.001). The cultures from the wires were positive in all untreated animals (median, 2.5 ؋ 10 3 CFU/implant), in 10 animals in the vancomycin group (median, 1.15 ؋ 10 3 CFU/ implant), and negative in all animals in the fosfomycin group. Based on the bacterial counts from the implants, vancomycin was not superior to the no-drug control (P ‫؍‬ 0.324), and fosfomycin was superior to the no-drug control and vancomycin (P < 0.001). No emergence of resistance was observed. In conclusion, it was demonstrated that fosfomycin monotherapy is highly effective for the treatment of experimental implant-associated MRSA osteomyelitis.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Fosfomycin Compared to Vancomycin in Treatment of Implant-Associated Chronic Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats

Poeppl

Lingscheid

Bernitzky

et al. 2014

Antimicrob Agents Chemother

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“…Vancomycin in combination with rifampicin or tigecycline was bactericidal against MRSA biofilms [46]. The inactivation of MRSA biofilms was significant by the synergistic application of arbekacin and fosfomycin [47]. Tobramycin at high-doses plus meropenem was strongly effective to treat Burkolderia cepacia and P. aeruginosa biofilms [48].…”

Section: Biofilm Control With Conventional Antibioticsmentioning

confidence: 99%

Antimicrobial Strategies Effective Against Infectious Bacterial Biofilms

Simões

2011

CMC

116

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Bacteria are able to adapt to undesirable changes in nutrient availability, environmental conditions and presence of antimicrobial products, as well as to immunological defenses. One particularly important example of bacterial adaptation is the ability to grow as part of a sessile community, commonly referred to as biofilm. It is a natural tendency of microorganisms to attach to biotic or abiotic surfaces, to multiply and to embed themselves in a slimy matrix, resulting in biofilms. Biofilms are the leading example of physiological adaptation and are one of the most important sources of bacterial resistance to antimicrobials. It is now recognized that most bacterial-associated infections, including endocarditis, dental caries, middle ear infections, osteomyelitis, medical device-related infections and chronic lung infections in cystic fibrosis patients are problematic because of biofilms. Bacteria in biofilms demonstrate intrinsic resistance to antimicrobial stress more effectively than the planktonic counterparts. Antimicrobial concentrations necessary to inhibit bacterial biofilms can be up to 10-1000 times higher than those needed to inhibit the same bacteria grown planktonically. Thus, in the presence of therapeutically available antibiotic concentrations biofilms remain viable after treatment. Therefore, the identification of new antimicrobials that inhibit or destroy biofilms is needed. The aim of this review is to cover the recent advances on the studies of antimicrobial strategies effective against infectious bacterial biofilms, including the current developments in the structure-activity relationship of those effective antimicrobials.

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“…FOF powder (Sandoz, Kundl, Austria) was dissolved in sterile water and administered intraperitoneally at a dose of 150 mg/kg of body weight once daily. The rationale for the treatment regimen was to achieve serum levels of drug closely mimicking those obtained in humans (2,(13)(14)(15)19). Twelve hours after completion of antimicrobial therapy, the rats were euthanized.…”

mentioning

confidence: 99%

Efficacy of Fosfomycin in Experimental Osteomyelitis Due to Methicillin-Resistant Staphylococcus aureus

Poeppl

Tobudic

Lingscheid

et al. 2011

Antimicrob Agents Chemother

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The activity of fosfomycin was evaluated in an experimental methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis model. Eighteen rats were treated for 4 weeks with 150 mg of fosfomycin/kg of body weight intraperitoneally once daily or with saline placebo. After treatment, animals were euthanized and the infected tibiae were processed for quantitative bacterial culture. Bone cultures were positive for methicillinresistant S. aureus in all 9 (100%) untreated controls and in 2 of 9 (22.2%) fosfomycin-treated rats. Thus, fosfomycin treatment was significantly more efficacious than placebo. No development of resistance was observed after the 4-week treatment period.

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Synergistic effect of fosfomycin and arbekacin on a methicillin-resistant Staphylococcus aureus-induced biofilm in a rat model

Cited by 19 publications

References 26 publications

Efficacy of Fosfomycin Compared to Vancomycin in Treatment of Implant-Associated Chronic Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats

Efficacy of Fosfomycin Compared to Vancomycin in Treatment of Implant-Associated Chronic Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats

Antimicrobial Strategies Effective Against Infectious Bacterial Biofilms

Efficacy of Fosfomycin in Experimental Osteomyelitis Due to Methicillin-Resistant Staphylococcus aureus

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