Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells

Tuerdi, Guligena; Ichinomiya, Saki; Sato, Hiromi; Siddig, Sana; Suwa, Eriko; Iwata, Hiroki; Yano, Tomohiro; Ueno, Koichi

doi:10.1016/j.canlet.2013.07.015

Cited by 15 publications

(31 citation statements)

References 56 publications

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“…autophagy induction and ER stress-mediated apoptosis Tiwari et al, 2015). Furthermore, tocotrienols have been successfully used as anticancer agents in combination therapies (Abdul Kani et al, 2013;Malaviya and Sylvester, 2013;Rezaei et al, 2014;Sylvester et al, 2011;Tiwari et al, 2015;Tuerdi et al, 2013;Yusof et al, 2015), as agents against cardiovascular diseases (Prasad, 2011) and as radioprotectors in patients undergoing radiotherapy (Kulkarni et al, 2010;Singh et al, 2013).…”

Section: Thcmentioning

confidence: 99%

Inhibitors of dihydroceramide desaturase 1: Therapeutic agents and pharmacological tools to decipher the role of dihydroceramides in cell biology

Casasampere

Ordóñez

Pou

et al. 2016

Chemistry and Physics of Lipids

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Section: Thcmentioning

confidence: 99%

Inhibitors of dihydroceramide desaturase 1: Therapeutic agents and pharmacological tools to decipher the role of dihydroceramides in cell biology

Casasampere

Ordóñez

Pou

et al. 2016

Chemistry and Physics of Lipids

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“…In addition, the combination of lovastatin and valproate was shown to reduce cell invasion of Acc-Meso-1, a human-derived MPM cell line [110]. HWANG et al [51] reported a synergistic effect of the combination of pemetrexed and simvastatin on apoptosis induction in MSTO-211 MPM cells by reactive oxygen [43] Inhibition of angiogenesis [44] Inhibition of invasion and metastasis [45] Induction of tumour differentiation [46] Reversion of multidrug resistance [47] Phase III: gastric cancer [48], colorectal cancer [49] Phase III: ongoing in SCLC [50] Preclinical [47,[51][52][53] Itraconazole Antifungal Induction of angiogenesis [54] Inhibition of hedgehog pathway [8] Phase II: NSCLC [55] Prostate cancer [56] Basal cell carcinoma [57] Preclinical [58] Arsenic trioxide Preclinical [52,85,88] Thalidomide Sickness in pregnant females (withdrawn) [29] Inhibition of angiogenesis [31] Inhibition of cell proliferation [32] Immunomodulatory function [33] FDA approved: multiple myeloma [34] Phase III [37] Anisomycin Antibiotic Induction of apoptosis [89] Preclinical [90] Preclinical [90]…”

Section: Statinsmentioning

confidence: 99%

“…RIGANTI et al [47] showed that statins revert doxorubicin resistance by increasing nitric oxide production in human MPM cells MM98, OC99 and GF99. Additionally, statins have been shown to exert synergistic antiproliferative effects with γ-tocotrienol (isoform of vitamin E) on human MPM cells H2052 (sarcomatoid), H28 (epithelioid), H2452 (biphasic) and MSTO-211H (biphasic; MSTO) via inhibition of the mevalonate pathway, induction of endoplasmic reticulum stress and caspase 3 activation [52]. The potential of lovastatin alone has also been demonstrated in vivo as it significantly reduced primary tumour and metastasis in a NOD/SCID/ γ-null (NOG) mouse model of human MPM [53].…”

Section: Zoledronic Acidmentioning

confidence: 99%

“…In vitro, NAKASHIMA et al [85] showed that the TRF extracted from rice attenuates the chemoresistance to cisplatin by inactivating the PI3K/Akt pathway in H28, a human cisplatin-resistant MPM cell line. In combination with statins, γ-T3 exerts antiproliferative effects [52] on human sarcomatoid, epithelioid and biphasic MPM cells through inhibition of the mevalonate pathway, induction of endoplasmic reticulum stress and caspase 3 activation. γ-T3 has not been investigated in vivo or in clinical trials in MPM.…”

Section: Vitamin E Isoformmentioning

confidence: 99%

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Drug repurposing in malignant pleural mesothelioma: a breath of fresh air?

et al. 2018

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Drug repurposing is the use of known drugs for new indications. Malignant pleural mesothelioma (MPM) is a rare cancer with a poor prognosis. So far, few treatments have been approved in this disease. However, its incidence is expected to increase significantly, particularly in developing countries. Consequently, drug repurposing appears as an attractive strategy for drug development in MPM, since the known pharmacology and safety profile based on previous approvals of repurposed drugs allows for faster time-to-market for patients and lower treatment cost. This is critical in low- and middle-income countries where access to expensive drugs is limited. This review assesses the published preclinical and clinical data about drug repurposing in MPM.In this review, we identified 11 therapeutic classes that could be repositioned in mesothelioma. Most of these treatments have been evaluated , half have been evaluated in animal models of MPM and only three ( valproate, thalidomide and zoledronic acid) have been investigated in clinical trials, with limited benefits so far. Efforts could be coordinated to pursue further investigations and test promising drugs identified in preclinical experiments in appropriately designed clinical trials.

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“…Interestingly, Gopalan et al () demonstrated that a combination of γ‐TT and simvastatin is able to eliminate the cancer stem cell subpopulation in drug‐resistant human breast cancer cells. A synergistic effect of combined treatment with γ‐TT and statins has been reported also in malignant mesothelioma cells (Tuerdi et al, ).…”

Section: Synergistic Anticancer Properties Of Tts With Standard Treatmentioning

confidence: 81%

Anticancer properties of tocotrienols: A review of cellular mechanisms and molecular targets

Marelli

Marzagalli

Fontana

et al. 2018

Journal Cellular Physiology

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Vitamin E is composed of two groups of compounds: α-, β-, γ-, and δ-tocopherols (TPs), and the corresponding unsaturated tocotrienols (TTs). TTs are found in natural sources such as red palm oil, annatto seeds, and rice bran. In the last decades, TTs (specifically, γ-TT and δ-TT) have gained interest due to their health benefits in chronic diseases, based on their antioxidant, neuroprotective, cholesterol-lowering, anti-inflammatory activities. Several in vitro and in vivo studies pointed out that TTs also exert a significant antitumor activity in a wide range of cancer cells. Specifically, TTs were shown to exert antiproliferative/proapoptotic effects and to reduce the metastatic or angiogenic properties of different cancer cells; moreover, these compounds were reported to specifically target the subpopulation of cancer stem cells, known to be deeply involved in the development of resistance to standard therapies. Interestingly, recent studies pointed out that TTs exert a synergistic antitumor effect on cancer cells when given in combination with either standard antitumor agents (i.e., chemotherapeutics, statins, "targeted" therapies) or natural compounds with anticancer activity (i.e., sesamin, epigallocatechin gallate (EGCG), resveratrol, ferulic acid). Based on these observations, different TT synthetic derivatives and formulations were recently developed and demonstrated to improve TT water solubility and to reduce TT metabolism in cancer cells, thus increasing their biological activity. These promising results, together with the safety of TT administration in healthy subjects, suggest that these compounds might represent a new chemopreventive or anticancer treatment (i.e., in combination with standard therapies) strategy. Clinical trials aimed at confirming this antitumor activity of TTs are needed.

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Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells

Cited by 15 publications

References 56 publications

Inhibitors of dihydroceramide desaturase 1: Therapeutic agents and pharmacological tools to decipher the role of dihydroceramides in cell biology

Inhibitors of dihydroceramide desaturase 1: Therapeutic agents and pharmacological tools to decipher the role of dihydroceramides in cell biology

Drug repurposing in malignant pleural mesothelioma: a breath of fresh air?

Anticancer properties of tocotrienols: A review of cellular mechanisms and molecular targets

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