Synergistic effect of Cinnamomum zeylanicum and Murraya koenigii formulation for antiobesity and hypolipidemic activity on wistar albino rats

Kumar, P. M.; Singh, Sangam; Ahmad, Iftekhar

doi:10.1007/s13596-020-00460-8

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…Herbal medicines are frequently used in developing countries for alternative healthcare after synthetic drugs. Herbal medicines such as plant extracts are attractive alternatives because of their familiar and hereditary use in society; moreover, they are nontoxic, inexpensive, readily available, and have minimum side effects due to their antioxidant presence (Djati and Christina 2019;Kumar et al 2020). Soybean (Glycine max) is recognized as a healthful food due to its highquality protein, dietary fiber, and isoflavones-rich content (Pabich and Materska 2019).…”

Section: Introductionmentioning

confidence: 99%

Soybean Elicited with Saccharomyces cerevisiae and Light Attenuates Stromal-Derived Factor-1 Associated with CXCR4 in High-Fat/Fructose Diet Mice

Safitri¹,

Christina²,

illah³

et al. 2023

NLSC

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Soybean elicited with microorganisms transforms its phytochemical content which is rich in anti-inflammatory action. However, the potential effect of the elicited soybean extract (ESE) on the maintenance of the stromal-derived factor-1 (SDF-1) regulatory system in the spleen, thymus, hepar, and bone marrow in high-fat/fructose diet (HFFD) mice is yet to be investigated. In our study, the spleen, thymus, hepar, and femurs were collected and isolated at the end of the experiment. The expression of SDF-1 in hepar, CD4+, CD8+, T cells, and B220+ cells was measured using flow cytometry analysis. To determine the interaction between the active compound of ESE and CXCR4, docking analysis was conducted using PyRx 0.8. The expression of splenic and thymic CD4+SDF-1+, CD8+SDF-1+, and hepatic SDF-1+ was elevated in HFFD mice but not in normal diet (ND) mice. ESE had significantly declined (P < 0.05) in CD4+SDF-1+ and CD8+SDF-1+ T-cells subsets. ESE treatment improved the development of B cells in HFFD mice. The molecular docking analysis identified glyceollin I with the strongest affinity of −8.4 kcal/mol. The results suggest that glyceollin I has a positive effect as a CXCR4 inhibitor. ESE supplementation was significant in maintaining the regulatory system of SDF-1 expressed by CD4+, CD8+, hepatocyte, and B220+ cells in HFFD associated with obesity Keywords: CXCR4, Glyceollin, High-fat, High-fructose, SDF-1, Soybean

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Section: Introductionmentioning

confidence: 99%

Soybean Elicited with Saccharomyces cerevisiae and Light Attenuates Stromal-Derived Factor-1 Associated with CXCR4 in High-Fat/Fructose Diet Mice

Safitri¹,

Christina²,

illah³

et al. 2023

NLSC

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“…The MK leaves are used as appetizers, digestives, analgesics, and anthelmintics in Indian cooking ( Bhandari, 2012 ; Desai et al, 2012 ). Modern research has now highlighted the potential of MK leaves as a potent antidiabetic ( Yadav et al, 2002 ; Adebajo et al, 2005 ; Kesari et al, 2005 ), antifungal ( Murugan et al, 2013 ), nephroprotective ( Mahipal and Pawar, 2017 ), nitric oxide scavenging ( Gul et al, 2012 ), antioxidant ( Bhatt et al, 2020 ), anti-inflammatory, antibacterial ( Rautela et al, 2018 ), anti-cancer ( Satyavarapu et al, 2020 ), immuno-modulatory ( Gurjar and Pal, 2021 ), antihypertensive ( An et al, 2020 ) anti-obesity ( Kumar et al, 2020 ) and lipid lowering agent ( Sandamali et al, 2020 ).These unique medicinal properties of MK leaves are accredited to their diverse metabolites. These include carbazole alkaloids, flavonoids, terpenoids, carbohydrates, phenolics, carotenoids, vitamins, essential oils, tannins, quinones, nicotinic acid, etc.…”

Section: Introductionmentioning

confidence: 99%

Deciphering the growth stage specific bioactive diversity patterns in Murraya koenigii (L.) Spreng. using multivariate data analysis

et al. 2022

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The study was undertaken to characterize the total phenolics, flavonoids, essential oils, quinones, tannins and antioxidant activity of 15 samples of wild Murraya koenigii (L.) Spreng. (MK) leaves obtained from different locations of Himachal Pradesh at various growth stages. The results indicated a significant variation in total phenolic content which ranged from [(170.09 ± 4.59 to 303.57 ± 7.94) in pre-flowering, (266.48 ± 7.49 to 450.01 ± 11.78) in the flowering stage, and (212.72 ± 5.37 to 363.85 ± 9.79) in fruiting stage], expressed as mg tannic acid equivalents (TAE)/g. The total flavonoid content ranged from [(15.17 ± 0.36 to 33.40 ± 0.81) in pre-flowering, (25.16 ± 0.67 to 58.17 ± 1.52) in flowering stage, and (17.54 ± 0.42 to 37.34 ± 0.97) in fruiting stage], expressed as mg catechin equivalent (CE)/g. Total tannin content ranged from [(75.75 ± 1.69 to 143 ± 3.74) in pre-flowering, (116 ± 3.26 to 207 ± 5.42) in the flowering stage, and (47 ± 1.18 to 156 ± 4.05) in fruiting stage], expressed as mg TAE/g. The essential oil content ranged from (0.64 ± 0.01 to 0.89 ± 0.02%) in pre-flowering, (0.85 ± 0.02 to 1 ± 0.02%) in flowering stage, and (0.54 ± 0.01 to 0.7 ± 0.01%) in fruiting stage. Quinones ranged from [(2.05 ± 0.05 to 2.97 ± 0.07) in pre-flowering, (3.07 ± 0.07 to 4.95 ± 0.13) in flowering stage, and (1.02 ± 0.02 to 1.96 ± 0.04) in fruiting stage], expressed as mM/min/g tissue. Antioxidant activity ranged from [(4.01 ± 0.09 to 7.42 ± 0.17) in pre-flowering, (8.08 ± 0.19 to 13.60 ± 0.35) in flowering stage, and (3.11 ± 0.06 to 6.37 ± 0.15) in fruiting stage], expressed as μg/ml. Data was subjected to multivariate analysis using principal component analysis (PCA), hierarchical clustering analysis (HCA). This was used for elucidating the intricate relationships between the phytochemical properties. All evaluated phytochemical parameters significantly increased during the growth transition from pre-flowering to the flowering stage, followed by their gradual decrease during the fruiting stage. The present study can serve as rationale for commercializing MK for aromatic and phytopharmaceutical industries.

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Herbal Medicines for the Management of Obesity

Kılıç

2023

Role of Herbal Medicines

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Synergistic effect of Cinnamomum zeylanicum and Murraya koenigii formulation for antiobesity and hypolipidemic activity on wistar albino rats

Cited by 3 publications

References 37 publications

Soybean Elicited with Saccharomyces cerevisiae and Light Attenuates Stromal-Derived Factor-1 Associated with CXCR4 in High-Fat/Fructose Diet Mice

Soybean Elicited with Saccharomyces cerevisiae and Light Attenuates Stromal-Derived Factor-1 Associated with CXCR4 in High-Fat/Fructose Diet Mice

Deciphering the growth stage specific bioactive diversity patterns in Murraya koenigii (L.) Spreng. using multivariate data analysis

Herbal Medicines for the Management of Obesity

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