Synergistic effect of chemo-photothermal therapy using PEGylated graphene oxide

Zhang, Wen; Guo, Zhouyi; Huang, Deqiu; Liu, Zhiming; Guo, Xiaolong; Zhong, Huiqing

doi:10.1016/j.biomaterials.2011.07.071

Cited by 817 publications

(539 citation statements)

References 38 publications

Supporting

Mentioning

532

Contrasting

Order By: Relevance

“…Such approach was first explored with the simultaneous delivery of the anticancer drug doxorubicin and a siRNA targeted against Bcl-2, which is often linked to multidrug resistance, in a PEI-GO vector. The synergy of both therapies was confirmed 69 . In Zhi et al's work, a similar rationale was followed with a PEI-PSS-Go carrier for anti-miR-21 siRNA and the anticancer drug adriamycin 44 .…”

Section: Intracellular Molecular Sensingmentioning

confidence: 76%

Graphene materials as 2D non-viral gene transfer vector platforms

2016

View full text Add to dashboard Cite

Advances in genomics and gene therapy could offer solutions to many diseases that remain incurable today, however one of the critical reasons halting clinical progress is due to the difficulty in designing efficient and safe delivery vectors for the appropriate genetic cargo. Safety and largescale production concerns counter-balance the high gene transfer efficiency achieved with viral vectors, while non-viral strategies have yet to become sufficiently efficient. The extraordinary physicochemical, optical and photothermal properties of graphene-based materials (GBMs) could offer two-dimensional (2D) components for the design of nucleic acid carrier systems. We discuss here such properties and their implications for the optimization of gene delivery. While the design of such vectors is still in its infancy, we provide here an exhaustive and up-to-date analysis of the studies that have explored GBMs as gene transfer vectors, focusing on the functionalization strategies followed to improve vector performance and on the biological effects attained.

show abstract

Section: Intracellular Molecular Sensingmentioning

confidence: 76%

Graphene materials as 2D non-viral gene transfer vector platforms

2016

View full text Add to dashboard Cite

show abstract

“…6. Nanocarriers combine chemotherapy with physically destructive modalities that induce tumor ablation (photothermal/magnetic) [218][219][220][221][222][223][224][225][226][227][228][229][230][231][232][233][234][235][236]245,246], generate reactive oxygen species (photodynamic) [232][233][234][235][236][237][238][239][240][241][242], and form of free radicals (radiotherapy) to maximize cancer eradication [243]. [246] and demonstrated higher anticancer activity in vitro and in vivo than PTX/PLGA/HAuNPs microspheres alone (no NIR-irradiation) or PLGA/HAuNPs microspheres (no PTX) with NIR irradiation.…”

Section: Combined Photothermal and Chemotherapymentioning

confidence: 99%

“…RGD peptide-linked, DTX-conjugated single-walled CNTs (RGD/DTX/SWNT) [229] demonstrated higher tumor-suppressing efficacy upon NIR irradiation than DTX both in PC3 cell line and a murine S180 cancer model. Combined photothermal and chemotherapy using DOX-loaded PEGylated nanographene oxide (NGO-PEG-DOX) [230] demonstrated synergistically enhanced therapeutic effects with low toxicity in main organs. A targeted, combined photothermal and chemotherapy was also demonstrated in vitro using polyvinylpyrrolidone (PVP)-functionalized, folic acid (FA) conjugated NGO (FA-NGO-PVP) [231].…”

Section: Combined Photothermal and Chemotherapymentioning

confidence: 99%

“Combo” nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy

Kemp

Shim

Heo

et al. 2016

Advanced Drug Delivery Reviews

410

242

View full text Add to dashboard Cite

a b s t r a c t a r t i c l e i n f oThe dynamic and versatile nature of diseases such as cancer has been a pivotal challenge for developing efficient and safe therapies. Cancer treatments using a single therapeutic agent often result in limited clinical outcomes due to tumor heterogeneity and drug resistance. Combination therapies using multiple therapeutic modalities can synergistically elevate anti-cancer activity while lowering doses of each agent, hence, reducing side effects. Co-administration of multiple therapeutic agents requires a delivery platform that can normalize pharmacokinetics and pharmacodynamics of the agents, prolong circulation, selectively accumulate, specifically bind to the target, and enable controlled release in target site. Nanomaterials, such as polymeric nanoparticles, gold nanoparticles/cages/shells, and carbon nanomaterials, have the desired properties, and they can mediate therapeutic effects different from those generated by small molecule drugs (e.g., gene therapy, photothermal therapy, photodynamic therapy, and radiotherapy). This review aims to provide an overview of developing multi-modal therapies using nanomaterials ("combo" nanomedicine) along with the rationale, up-to-date progress, further considerations, and the crucial roles of interdisciplinary approaches.

show abstract

“…Liu et al first reported the combined use of GO with PTT in successful tumour suppression [83]. DOXloaded PEGylated NGO can deliver the drug to the tumourigenic region along with the heat that is generated to facilitate combined chemotherapy and photothermal treatment [138]. This approach is more useful than chemotherapy or photothermal treatment alone.…”

Section: Photothermal Therapymentioning

confidence: 99%

Graphene and graphene oxide as nanomaterials for medicine and biology application

et al. 2018

View full text Add to dashboard Cite

Graphene-and graphene oxide-based nanomaterials have gained broad interests in research because of their unique physiochemical properties. The 2D allotropic structure allows it to be used in various biological fields. The biomedical applications of graphene and its composite include its use in gene and small molecular drug delivery. It is further used for biofunctionalization of protein, in anticancer therapy, as an antimicrobial agent for bone and teeth implantation. The biocompatibility of the newly synthesized nanomaterials allows its substantial use in medicine and biology. The current review summarizes the chemical structure and biological application of graphene in various fields.

show abstract

Synergistic effect of chemo-photothermal therapy using PEGylated graphene oxide

Cited by 817 publications

References 38 publications

Graphene materials as 2D non-viral gene transfer vector platforms

Graphene materials as 2D non-viral gene transfer vector platforms

“Combo” nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy

Graphene and graphene oxide as nanomaterials for medicine and biology application

Contact Info

Product

Resources

About