Synergistic effect of ACE and AGT genes in coronary artery disease

Borai, Ibrahim H.; Hassan, Nahla S.; Shaker, Olfat; Ashour, Esmat; Badrawy, Mohammed El; Fawzi, Olfat M.; Mageed, Lamiaa

doi:10.1016/j.bjbas.2017.09.003

Cited by 9 publications

(10 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Khamlaoui et al indicated the relation of AGT genotypes with dyslipidemia, that is, reliably higher parameters of TC and LDL-C among the ТТ genotype carriers [17]. Borai et al stated that patients with ischemic heart disease present a considerable difference between AGT genotypes concerning HDL-C with the value р < 0.05 [8]. Junusbekov also affirmed that the CC genotype of rs699 was significantly related to HDL-C levels (p = 0.020) [18].…”

Section: Discussionmentioning

confidence: 98%

“…EAH is a multifactorial disease that includes such factors as dyslipidemia, smoking, DM [10], [13], and obesity [13], [14]. Genes determine approximately 20-60% of BP variability and some peculiarities of hypertensive-mediated organs damage in different populations [6], [7], [8], [11], [15].…”

Section: Discussionmentioning

confidence: 99%

“…Obesity, lack of physical activity, and excessive salt intake are the most well-known environmental factors associated with EAH. An increased risk of CV complications is associated with dyslipidemia as well [8]. It plays an important role in the formation of the atherosclerotic lesions of the arteries in general including the kidneys and cardiac muscle [1].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of Lipids’ Metabolism with Vitamin D Receptor (rs10735810, rs222857) and Angiotensinogen (rs699) Genes Polymorphism in Essential Hypertensive Patients

Repchuk

Sydorchuk²,

Fedoniuk

et al. 2021

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND: Cardiovascular (CV) diseases are the most spread cause of mortality in the world. Essential arterial hypertension (EAH), as a major risk factor for the development of CV diseases, is a multifactorial disease involving environmental and genetic factors together with risk-conferring behaviors. AIM: The purpose of this study was to analyze lipid metabolism changes in patients with EAH depending on the Vitamin D receptor (VDR rs2228570 (aka rs10735810)) and angiotensinogen (AGT rs699) genes polymorphism. MATERIALS AND METHODS: The single-stage study involved 100 patients suffering from Stage 2 EAH, 1–3 degrees of blood pressure increase, high and very high CV risks, 21% (21) men, and 79% (79) women. The average age of patients was 59.86 ± 6.22 years old. The control group included 60 practically healthy individuals of an appropriate age and sex distribution. To examine the VDR gene (rs10735810, rs2228570) and AGT gene (rs699) polymorphism, a qualitative real-time polymerase chain reaction was made. The lipid metabolism was studied by determining the blood plasma content of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TGs). RESULTS: Т allele of AGT gene is associated with reduced HDL-C level in men and increased TGs level in women. The EAH risk increases 4.5 times as much among the ТС-genotype carriers and lowered HDL-C level (odds ratio [OR] = 6.43; p = 0.01). The EAH risk increases as far as the HDL-C level reduction, irrespective of the VDR gene alleles condition 1.83 times (OR = 2.37; OR 95% confidence interval [CI]: 1.02–5.51; p = 0.04) and 1.9 times (OR=2.43; OR 95% CI: 0.99–5.97; p = 0.04). HDL-C reduction and LDL-C elevation in women increase the EAH risk 2.4 times (OR = 3.27; p = 0.01) and 1.24 times (OR = 3.67; p = 0.01), respectively. CONCLUSIONS: The EAH risk increases with a reduced HDL-C level in the TC genotype carriers of the AGT gene and irrespective of VDR gene polymorphic variants.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of Lipids’ Metabolism with Vitamin D Receptor (rs10735810, rs222857) and Angiotensinogen (rs699) Genes Polymorphism in Essential Hypertensive Patients

Repchuk

Sydorchuk²,

Fedoniuk

et al. 2021

Open Access Maced J Med Sci

View full text Add to dashboard Cite

show abstract

“…Additionally, in a multicenter case–control study Keavney et al [ 113 ] did not identify an association between the ACE DD genotype and an increased risk of MI [ 113 ]. On the other hand, Borai et al [ 114 ] identified that the concomitant presence of ACE (I/D) and AGT (M235T) polymorphisms increases the risk of developing CAD, and each of the ACE D and AGT T alleles could be considered an independent risk factor for CAD [ 114 ].…”

Section: Polygenic Cad: Genes and Polymorphisms Associated With Cadmentioning

confidence: 99%

Etiologic Puzzle of Coronary Artery Disease: How Important Is Genetic Component?

Butnariu

Florea

Bădescu

et al. 2022

Life

View full text Add to dashboard Cite

In the modern era, coronary artery disease (CAD) has become the most common form of heart disease and, due to the severity of its clinical manifestations and its acute complications, is a major cause of morbidity and mortality worldwide. The phenotypic variability of CAD is correlated with the complex etiology, multifactorial (caused by the interaction of genetic and environmental factors) but also monogenic. The purpose of this review is to present the genetic factors involved in the etiology of CAD and their relationship to the pathogenic mechanisms of the disease. Method: we analyzed data from the literature, starting with candidate gene-based association studies, then continuing with extensive association studies such as Genome-Wide Association Studies (GWAS) and Whole Exome Sequencing (WES). The results of these studies revealed that the number of genetic factors involved in CAD etiology is impressive. The identification of new genetic factors through GWASs offers new perspectives on understanding the complex pathophysiological mechanisms that determine CAD. In conclusion, deciphering the genetic architecture of CAD by extended genomic analysis (GWAS/WES) will establish new therapeutic targets and lead to the development of new treatments. The identification of individuals at high risk for CAD using polygenic risk scores (PRS) will allow early prophylactic measures and personalized therapy to improve their prognosis.

show abstract

“…The association of at least 2 genes increases the risk of cardiovascular complications, such as LVH, IHD and heart failure, in hypertensive patients ( 4 , 27 , 28 ).…”

Section: Introductionmentioning

confidence: 99%

Association between polymorphisms of genes involved in the Renin‑Angiotensin‑Aldosterone System and the adaptive morphological and functional responses to essential hypertension

et al. 2021

View full text Add to dashboard Cite

Hypertensive cardiac remodeling is illustrated by increased left ventricular (LV) mass index values and/or relative wall thickness (RWT) values >0.42, and functionally by isolated alteration of LV diastole (abnormal relaxation). The aim of the present study was to establish differentiated models of anatomical and functional adaptation to essential hypertension (EHT), in relation to the genetic variants of genes involved in the Renin-Angiotensin-Aldosterone System (RAAS). The M235T-AGT, I/D-ACE, A1166C-R1AngII, A3123C-R2AngII and G83A-REN genotypes were determined using PCR-Restriction Fragment Length Polymorphism in 139 hypertensive subjects. The relationship between the studied RAAS gene polymorphisms with morphological and functional cardiac remodeling was assessed by multiple logistic regression analysis. Patients carrying the C/C, A/C genotypes (A3123C-R2AngII polymorphism) had a 2.72-fold (P=0.033) increased risk of exhibiting an RWT value <0.42; in the multivariate model the risk was 4.02-fold higher (P=0.008). Analysis of LV diastolic dysfunction (LVDD) revealed that hypertensive patients carrying the T/T, M/T genotypes (M235T-AGT polymorphism) had a 2.24-fold (P=0.037) increased risk of developing LVDD and a 2.42-fold increased risk (P=0.039) after adjustment for confounders. Similarly, carriers of the G/G, A/G genotypes (G83A-REN) had a 2.32-fold (P=0.021) increased risk of developing LVDD, and this remained an independent risk factor based on the multivariate model (P=0.033). The results of the present study showed that no particular gene was associated with increased LV mass, but the A3123C-R2AngII polymorphism was associated with a non-concentric type of cardiac response in hypertensive patients. Conversely, the M235T-AGT and G83A-REN polymorphisms were found to be statistically significantly associated with LVDD when assessing abnormal relaxation.

show abstract

Synergistic effect of ACE and AGT genes in coronary artery disease

Cited by 9 publications

References 34 publications

Association of Lipids’ Metabolism with Vitamin D Receptor (rs10735810, rs222857) and Angiotensinogen (rs699) Genes Polymorphism in Essential Hypertensive Patients

Association of Lipids’ Metabolism with Vitamin D Receptor (rs10735810, rs222857) and Angiotensinogen (rs699) Genes Polymorphism in Essential Hypertensive Patients

Etiologic Puzzle of Coronary Artery Disease: How Important Is Genetic Component?

Association between polymorphisms of genes involved in the Renin‑Angiotensin‑Aldosterone System and the adaptive morphological and functional responses to essential hypertension

Contact Info

Product

Resources

About