Synergistic effect of 5-fluorouracil and the flavanoid oroxylin A on HepG2 human hepatocellular carcinoma and on H22 transplanted mice

Abstract

The anti-hepatocellular carcinoma effects in vitro and in vivo of 5-FU and oroxylin A combinations were synergistic and oroxylin A increased the sensitivity of HepG2 cells to 5-FU by modulating the metabolic enzymes of 5-FU and apoptotic-related proteins.

Therapeutic effects of cantharidin analogues without bridging ether oxygen on human hepatocellular carcinoma cells

“…Effective anti-tumor agents such as 5-fluorouracil (5-FU) often induce neutropenia, the most common side effect, followed by gastrointestinal toxicity [17], especially at the high dosage necessary to achieve anti-tumor efficacy. A series of cantharidin analogues were synthesized and screened for their anticancer potential in an attempt to achieve relatively low toxicity to normal cells [18,19].…”

Flavonoids from tartary buckwheat induce G<sub>2</sub>/M cell cycle arrest and apoptosis in human hepatoma HepG2 cells

“…Under normal circumstances, its production and resolution are in dynamic balance, and the redox state of the intracellular environment maintains a stable state. A great deal of research indicated that many antitumor drugs are closely related to the ROS initiation within tumor cells [19][20][21]. Such as antitumor drug arsenic trioxide (As 2 O 3 ), polysaccharides, quinone anticancer drugs, and so on, they can produce a lot of ROS inducing tumor cell apoptosis [22].…”

LYG-202 Augments Tumor Necrosis Factor-α-Induced Apoptosis via Attenuating Casein Kinase 2-Dependent Nuclear Factor-κB Pathway in HepG2 Cells

“…Murine hepatoma 22 (H 22 ) cells were diluted with ice-cold 0.9% saline and inoculated subcutaneously at the right axilla of mice (5 ϫ 10 6 viable cells/ml) (Wang et al, 2008;Zhao et al, 2010). Twenty-four hours after inoculation, mice were divided randomly into 11 groups (with 10 mice/group): saline tumor control group; TNF-␣ 1.5 g/day group; LYG-202 750, 500, 250, and 125 mg/kg; LYG-202 750, 500, 250, and 125 mg/kg ϩ TNF-␣ combination group; and 10-hydroxycamptothecin 30 mg/kg group.…”