Synergistic catalysis by an aerogel supported ionic liquid phase (ASILP) in the synthesis of 1,5-benzodiazepines

Green Synthetic Approaches for Medium Ring-Sized Heterocycles of Biological Interest

“…The realization of these inherent problems of the use of ILs had led to the development of other concepts with an aim to reduce the amount of IL retaining their modular properties. Recently, silica aerogels [77], which possess suitable properties such as extremely low density, high porosity (80-99%), large surface area (500-1200 m 2 /g), and amorphous nature have been targeted for such use. Recently, silica aerogels [77], which possess suitable properties such as extremely low density, high porosity (80-99%), large surface area (500-1200 m 2 /g), and amorphous nature have been targeted for such use.…”

Zirconocene dichloride catalyzed multi-component synthesis of 1-amidoalkyl-2-naphthols at ambient temperature

“…In our continued interest in the development of highly expedient methodologies for the synthesis of bioactive scaffolds [43,44], we report herein the Cp 2 ZrCl 2 -catalyzed synthesis of 1-amidoalkyl-2-naphthols by MCR of 2-naphthol with a variety of aryl aldehydes and amides at ambient temperature (Scheme 1).…”

1,3-Disulfonic acid benzimidazolium chloride as an efficient and recyclable ionic liquid catalyst for the synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones

“…In this regard, ionic liquids have attracted significant research interest in the context of green synthesis due to their adjustable physical and chemical properties [3]. They have been introduced as an alternative green reaction medium given their exceptional features including high thermal and chemical stability, low vapor pressure, nonflammability, non-volatile nature, large electrochemical window, potential recyclability, and the ability to dissolve many organic and inorganic materials [4][5][6]. These compounds have been used extensively in electrochemistry, spectroscopy, and extraction and separation processes [7].…”