Synergistic Cascade Strategy Based on Modifying Tumor Microenvironment for Enhanced Breast Cancer Therapy

Zhang, Huan; Xu, Jinshun; Gao, Binyang; Wang, Hong; Huang, Jianbo; Zhou, Jie; Feng, Ye; Peng, Yulan

doi:10.3389/fphar.2021.750847

Cited by 2 publications

(1 citation statement)

References 60 publications

(80 reference statements)

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“… Liu et al (2022) administered silibinin and curcumin co-loaded nanoparticles into 4T1 tumour-bearing mice and received an excellent response by inhibiting BC metastasis. Zhang et al (2021a) designed a novel synergistic cascade strategy (SCS) that involved the use of mild hyperthermia and a smart drug delivery system (SDDS) to alter TME resistance for the effective therapy of TNBC. Shen et al (2018) engineered, formulated, and delivered genes encoding an IL-10 protein trap to change immunosuppressive TME.…”

Section: Discussionmentioning

confidence: 99%

Current perspectives and trends in nanoparticle drug delivery systems in breast cancer: bibliometric analysis and review

Sun,

Wang,

Gao

et al. 2023

Front. Bioeng. Biotechnol.

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The treatment of breast cancer (BC) is a serious challenge due to its heterogeneous nature, multidrug resistance (MDR), and limited therapeutic options. Nanoparticle-based drug delivery systems (NDDSs) represent a promising tool for overcoming toxicity and chemotherapy drug resistance in BC treatment. No bibliometric studies have yet been published on the research landscape of NDDS-based treatment of BC. In this review, we extracted data from 1,752 articles on NDDS-based treatment of BC published between 2012 and 2022 from the Web of Science Core Collection (WOSCC) database. VOSviewer, CiteSpace, and some online platforms were used for bibliometric analysis and visualization. Publication trends were initially observed: in terms of geographical distribution, China and the United States had the most papers on this subject. The highest contributing institution was Sichuan University. In terms of authorship and co-cited authorship, the most prolific author was Yu Zhang. Furthermore, Qiang Zhang and co-workers have made tremendous achievements in the field of NDDS-based BC treatment. The article titled “Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications” had the most citations. The Journal of Controlled Release was one of the most active publishers in the field. “Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries” was the most cited reference. We also analysed “hot” and cutting-edge research for NDDSs in BC treatment. There were nine topic clusters: “tumour microenvironment,” “nanoparticles (drug delivery),” “breast cancer/triple-negative breast cancer,” “combination therapy,” “drug release (pathway),” “multidrug resistance,” “recent advance,” “targeted drug delivery”, and “cancer nanomedicine.” We also reviewed the core themes of research. In summary, this article reviewed the application of NDDSs in the treatment of BC.

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Section: Discussionmentioning

confidence: 99%

Current perspectives and trends in nanoparticle drug delivery systems in breast cancer: bibliometric analysis and review

Sun,

Wang,

Gao

et al. 2023

Front. Bioeng. Biotechnol.

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Enhanced tumor penetration for efficient chemotherapy by a magnetothermally sensitive micelle combined with magnetic targeting and magnetic hyperthermia

Wang

Wang²,

Chen³

et al. 2022

Front. Pharmacol.

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The high accumulation and poor penetration of nanocarriers in tumor is a contradiction of nanomedicine, which reduces the efficacy of chemotherapy. Due to the positive effect of hyperthermia on in vivo drug diffusion, we designed a magnetothermally sensitive micelle (MTM) by integrating magnetic targeting (MT), magnetic hyperthermia (MH), and magnetothermally responsive drug release to facilitate simultaneous drug accumulation and penetration in tumor. Accordingly, we synthesized a cyanine7-modified thermosensitive polymer with phase transition at 42.3°C, and utilized it to prepare drug-loaded MTMs by encapsulating superparamagnetic MnFe2O4 nanoparticles and doxorubicin (DOX). The obtained DOX–MTM had not only high contents of DOX (9.1%) and MnFe2O4 (38.7%), but also some advantages such as superparamagnetism, high saturation magnetization, excellent magnetocaloric effect, and magnetothermal-dependent drug release. Therefore, DOX–MTM improved in vitro DOX cytotoxicity by enhancing DOX endocytosis under the assistance of MH. Furthermore, MT and MH enhanced in vivo DOX–MTM accumulation and DOX penetration in tumor, respectively, substantially inhibiting tumor growth (84%) with excellent biosafety. These results indicate the development of an optimized drug delivery system with MH and MH-dependent drug release, introducing a feasible strategy to enhance the application of nanomedicines in tumor chemotherapy.

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Synergistic Cascade Strategy Based on Modifying Tumor Microenvironment for Enhanced Breast Cancer Therapy

Cited by 2 publications

References 60 publications

Current perspectives and trends in nanoparticle drug delivery systems in breast cancer: bibliometric analysis and review

Current perspectives and trends in nanoparticle drug delivery systems in breast cancer: bibliometric analysis and review

Enhanced tumor penetration for efficient chemotherapy by a magnetothermally sensitive micelle combined with magnetic targeting and magnetic hyperthermia

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