Synergistic antioxidant activity of plant compositions contained in Chatuphalathika herbal recipe: Terminalia chebula Retz. var. chebula, Terminalia arjuna Wight and Arn., Terminalia bellirica (Gaertn.) Roxb., and Phyllanthus emblica L.

Suksaeree, Jirapornchai; Wunnakup, Thaniya; Monton, Chaowalit

doi:10.1007/s13596-021-00585-4

Cited by 8 publications

(6 citation statements)

References 35 publications

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“…Roxb. and Phyllanthus emblica L., was also found in the previous work [53]. The results supported those synergistic effects can occur among herbs or bioactive compounds of herbs [13].…”

Section: Synergistic Antioxidant Activity Of Plants' Combinationsupporting

confidence: 90%

Synergistic Antioxidant Activity and Optimal Microwave-Assisted Extraction Condition of Caesalpinia sappan L., Hibiscus sabdariffa L., and Clitoria ternatea L. Combinations

et al. 2022

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The aims of this work were to evaluate the synergistic antioxidant activity and optimize microwave-assisted extraction of Caesalpinia sappan L., Hibiscus sabdariffa L., and Clitoria ternatea L. combinations. The simplex lattice design was applied to evaluate the synergistic antioxidant activity. The mass ratios of the 3 plants that exhibited synergistic antioxidant activity were further used to investigate the optimal condition of microwave-assisted extraction by Box-Behnken design. Results showed that the synergistic antioxidant activity among the 3 plants: Which was determined by the combination index, was observed at various mass ratios, especially at the equal mass ratio. The optimal microwave-assisted extraction condition providing the best antioxidant activity of the plant extract was microwave power of 300 W for 30 s and 3 cycles. This condition gave the extraction yield of 31.03 ± 0.26 %, total phenolic content of 72.03 ± 3.83 mg GAE/g extract, total flavonoid content of 15.18 ± 0.42 mg CE/g extract, half-maximal inhibitory concentration (IC50) from DPPH assay of 178.16 ± 15.54 µg/mL and IC50 from FRAP assay of 75.26 ± 4.44 µg/mL. The optimal extract showed no toxicity on HepG2 cells although the tested concentration was up to 1 mg/mL with an IC50 value of 5.45 mg/mL. So, a mixture of the 3 colored plants could be used as a supplementary antioxidant product with a safety profile. HIGHLIGHTS Synergistic antioxidant activity was observed among three colored plants The optimal MAE condition was microwave power of 300 W for 30 s and three cycles The optimal extract did not toxic although the tested concentration was up to 1 mg/mL The IC50 of extract on cell viability was 5.45 mg/mL GRAPHICAL ABSTRACT

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“…Roxb. and Phyllanthus emblica L., was also found in the previous work [53]. The results supported those synergistic effects can occur among herbs or bioactive compounds of herbs [13].…”

Section: Synergistic Antioxidant Activity Of Plants' Combinationsupporting

confidence: 90%

Synergistic Antioxidant Activity and Optimal Microwave-Assisted Extraction Condition of Caesalpinia sappan L., Hibiscus sabdariffa L., and Clitoria ternatea L. Combinations

et al. 2022

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“…In place of administering one type of drug, the combination of two or three phytochemicals can be tried in this type of treatment, which requires further wet-lab experimental validation. Side of effect of these components also have to be analysed in vivo , although there is no notable side effect of T. chebula reported yet except diarrhea in some patients when administered in excess ( Suksaeree, Wunnakup, & Monton, 2021 ). Although extensive wet-lab experimental validation both in vitro and in vivo is required in future to make it applicable in reality, our study provides the insight into the application of phytochemicals from T. chebula in the treatment and prevention of COVID-19 which can help the scientific and health care communities further to develop effective drugs from plants.…”

Section: Discussionmentioning

confidence: 99%

Molecular docking studies of phytochemicals from Terminalia chebula for identification of potential multi-target inhibitors of SARS-CoV-2 proteins

Sarkar

Agarwal²,

Bandyopadhyay³

2022

Journal of Ayurveda and Integrative Medicine

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“…67 Chen et al (2011) reported that triethylchebulate, an aglycone isolated from T chebula, had a strong free-radical scavenger effect with an IC 50 value of 2.4 × 10 −5 M 68 , while Lee et al (2005) reported that the aqueous extract of the fruit of T chebula scavenged radical DPPH with an EC 50 of 127.1 ± 1.8 μg (dry matter)/mL. 69 Suksaeree et al 12 investigated the synergistic antioxidant activity of T chebula , T arjuna , T bellirica , and Phyllanthus emblica using response surface analysis. T chebula had the weakest antioxidant activity among the 4 species studied, with an IC 50 value of 14.50 μg/mL.…”

Section: Discussionmentioning

confidence: 99%

“…chebula (T chebula), family Combretaceae, is a medicinal herb that is widely grown in northeast Thailand. 12 The fruit of T chebula has a long history of traditional usage as an astringent for treating various ailments including gastrointestinal disorders, tumors, and skin diseases, as well as issues related to cardiovascular disorders and diabetes. [13][14][15] The bioactive chemicals present in T chebula are phenolic compounds including phenolic acids, tannins, and flavonoids 16 eg, gallic acid, 17 ellagic acid, 18 and chebulinic acid.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Antitumorigenic Activities of the Standardized Water Extract From Fruit of Terminalia chebula Retz. var. chebula

Takuathung

Wongnoppavich

Jaijoy

et al. 2023

Natural Product Communications

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Background Terminalia chebula Retz. var. chebula ( T chebula) has been traditionally used as a crude drug for treating various diseases, including skin disorders. This study aimed to investigate the potential antioxidant effects and antitumorigenic activity of an aqueous extract from the fruit of T chebula. Methods The extract's total phenolic content and antioxidant activity were measured using Folin-Ciocalteu, 1,1-diphenyl-2-picrylhydrazyl (DPPH), and ferric reducing antioxidant power (FRAP) tests, respectively. The 2 ´,7 ´-dichlorodihydrofluorescin diacetate assay was employed to evaluate the extract's ability to reduce intracellular reactive oxygen species (ROS) in U-937 human monocytic cell lines which had been treated with hydrogen peroxide for 30 min. Male ICR mice ( n = 30, 5 groups) were used to investigate the influence of T chebula extract on dimethylbenz[a]anthracene (DMBA)/12- O-tetradecanoylphorbol 13-acetate (TPA)-induced carcinogenesis. After 20 weeks of treatment with T chebula extract, tumor incidence, size, and number were assessed. The major phenolic compounds in the extract were determined using high-performance liquid chromatography. Statistical analysis was performed using ANOVA followed by post hoc least significant difference test. Results T chebula extract effectively reduced intracellular ROS and scavenged antioxidants in vitro. The IC50 values of the extract as measured by DPPH and FRAP assays were 109.0 ± 14.5 μg/mL and 2.39 ± 0.17 μg/mL, respectively. Moreover, 4 mg of T chebula extract significantly decreased the incidence, volume, and number of tumors in DMBA/TPA-induced skin tumorigenesis in mice. Conclusion T chebula extract effectively reduced intracellular ROS, and significantly decreased the incidence, volume, and number of tumors in DMBA/TPA-induced skin tumorigenesis in mice. These findings suggest that T chebula extract could be a promising therapeutic agent for skin tumors and other oxidative stress-related diseases.

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Synergistic antioxidant activity of plant compositions contained in Chatuphalathika herbal recipe: Terminalia chebula Retz. var. chebula, Terminalia arjuna Wight and Arn., Terminalia bellirica (Gaertn.) Roxb., and Phyllanthus emblica L.

Cited by 8 publications

References 35 publications

Synergistic Antioxidant Activity and Optimal Microwave-Assisted Extraction Condition of Caesalpinia sappan L., Hibiscus sabdariffa L., and Clitoria ternatea L. Combinations

Synergistic Antioxidant Activity and Optimal Microwave-Assisted Extraction Condition of Caesalpinia sappan L., Hibiscus sabdariffa L., and Clitoria ternatea L. Combinations

Molecular docking studies of phytochemicals from Terminalia chebula for identification of potential multi-target inhibitors of SARS-CoV-2 proteins

Antioxidant and Antitumorigenic Activities of the Standardized Water Extract From Fruit of Terminalia chebula Retz. var. chebula

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