Synergistic antinociception of propofol–alfentanil combination in mice

Wu, Yin; Jia, Na; Zhao, Chunjiang; Li, Yan; Shi, Xiaopeng; Li, Yuwen; Wang, Chao; Li, Ruili; Wang, Jingwen; Wen, Aidong

doi:10.1016/j.pbb.2013.10.005

Cited by 10 publications

(16 citation statements)

References 15 publications

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“…In contrast, other studies found that propofol had a hyperalgesic effect [28,29]. Recently, we reported the analgesic effect of propofol and the synergistic analgesic effects of propofol-alfentanil combination in mice [30]. In this study, we found that subhypnotic doses of fospropofol produced antinociceptive effects in a dose-dependent manner in the formalin, hot-plate and tail-flick tests.…”

Section: Discussioncontrasting

confidence: 66%

Synergistic antinociceptive interactions between fospropofol and alfentanil in mice

Zhao

Jia

Wang

et al. 2015

Pharmacological Reports

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Section: Discussioncontrasting

confidence: 66%

Synergistic antinociceptive interactions between fospropofol and alfentanil in mice

Zhao

Jia

Wang

et al. 2015

Pharmacological Reports

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“…Our previous study suggested that propofol and alfentanil exhibit synergetic effects. Combinations of intravenous anaesthetics with opioid analgesics have been used for achieving balanced anaesthesia with reduced sideeffects, and promote earlier recovery time and less postoperative nausea and vomiting (Wu et al 2014). The reported dose of propofol required to induce general anaesthesia in dogs is approximately 4 mg/kg (Auckburally et al 2008).…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, the efficacy of an admixture of propofol and alfentanil has been explored. Our earlier research suggested that the combination of alfentanil and propofol synergistically suppressed acute phasic and tonic pain in mice (Wu et al 2014). The combined effect of these agents has been previously associated with a favourable haemodynamic profile.…”

mentioning

confidence: 95%

The effects of a propofol/alfentanil admixture on total intravenous anaesthesia in dogs undergoing splenectomy

Jia¹,

Zhao²,

Wang³

et al. 2015

Vet. Med. - Czech

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ABSTRACT:The aim of this study was to compare the cardiovascular and respiratory effects and the bispectral scale index (BIS) as well as the recovery period characteristics in response to treatment with a propofol/alfentanil admixture of different concentrations in dogs undergoing splenectomy. We conducted a prospective, randomised, blinded experimental trial. Anaesthesia was induced and maintained by continuous-infusion anaesthesia of propofol and alfentanil or a propofol/alfentanil admixture after premedication with acepromazine (0.03 mg/kg). Dogs were assigned to receive different concentrations of the admixture. Changes in BIS value, heart rate (HR), respiratory rate (f R ), non-invasive arterial blood pressure, pulse oximetry (SpO 2 ), end-tidal carbon dioxide concentrations (ETCO 2 ) and rectal temperature (RT) were recorded at predefined time points during anaesthesia. Data [mean ± standard deviation (SD)] were analysed by analysis of variance (ANOVA) for repeated measures followed by a Dunnett's test and Student's t-test (P < 0.05) and where necessary, the Mann-Whitney U-test. No significant differences were found between groups with respect to age, body mass, SpO 2 , ETCO 2 , f R , systolic, diastolic and mean arterial blood pressure (SAP, DAP and MAP). BIS values were significantly lower in Group 2 when compared to Group 1 at T7, T8, T9. The HR of Group 2 was significantly lower at T2 to T9 when compared to Group 1. The propofol and alfentanil admixture provided satisfactory results in dogs undergoing splenectomy. Thus, an admixture of propofol/alfentanil may be used for total IV anaesthesia in dogs at the infusion rates determined in this study.

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“…For example, changes in pain perception are caused in many different ways by anesthetics such as thiopental, which can decrease the pain threshold caused by pressure stimulation and increase heat pain threshold 47. Despite it is the most widely used general anesthetic and exhibits analgesic properties, the clinical use of propofol has been debated 8910. It can decrease pain transmission in the rat spinal cord in vitro and in vivo studies and the subliminal dose of propofol has been reported to increase sensitivity to pain in many cases.…”

Section: Introductionmentioning

confidence: 99%

Effect of intravenous anesthesia with propofol versus isoflurane inhalation anesthesia in postoperative pain of inguinal herniotomy: a randomized clinical trial

et al. 2017

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Postoperative pain is a common problem after inguinal herniotomy. We aimed to compare the intravenous anesthesia effects of propofol and isoflurane inhalation anesthesia on postoperative pain after inguinal herniotomy. In a randomized clinical trial, 102 eligible patients were selected based on inclusion and exclusion criteria and were randomly divided in two groups. In the first group, propofol was used for the maintenance of anesthesia, while isoflurane was used in the second group. The patient’s heart rate, systolic and diastolic blood pressure and oxygen saturation before, during and after surgery, recovery time and postoperative pain were measured immediately, 2, 4 and 6 hours after surgery and compared between two groups. T-test, and repeated measurement test were used for statistical analysis. No statistically significant differences were observed in heart rate, blood pressure and oxygen saturation levels between the two groups (P > 0.05). Propofol has higher effect in easing postoperative pain of patients than isoflurane, but no difference in postoperative complications, including chills, nausea and vomiting, occurs in both two groups. Propofol is effective in declining the postoperative pain of patients after anesthesia in comparison with isoflurane. Moreover, due to the antioxidant, anti-inflammatory and analgesic properties of propofol, it is preferred to isoflurane and the authors recommended it to be used.

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Synergistic antinociception of propofol–alfentanil combination in mice

Cited by 10 publications

References 15 publications

Synergistic antinociceptive interactions between fospropofol and alfentanil in mice

Synergistic antinociceptive interactions between fospropofol and alfentanil in mice

The effects of a propofol/alfentanil admixture on total intravenous anaesthesia in dogs undergoing splenectomy

Effect of intravenous anesthesia with propofol versus isoflurane inhalation anesthesia in postoperative pain of inguinal herniotomy: a randomized clinical trial

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