Synergistic antidiabetic activity of Taraxacum officinale (L.) Weber ex F.H.Wigg and Momordica charantia L. polyherbal combination

Perumal, N. K.; Nallappan, Meenakshii; Shohaimi, Shamarina; Kassim, Nur Kartinee; Tee, Thiam Tsui; Cheah, Yew Hoong

doi:10.1016/j.biopha.2021.112401

Cited by 18 publications

(7 citation statements)

References 52 publications

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“…The α-amylase inhibition activity of the GAECE was evaluated using the iodine-starch method with slight modifications to the protocol outlined by Perumal et al (2022) and Ismail et al (2018). Initially, the GAECE was dissolved in DMSO and the serially diluted six-fold.…”

Section: In Vitro Antidiabetic Assays α-Amylase Inhibition Assaymentioning

confidence: 99%

“…Furthermore, the use of these drugs is limited due to their high cost and adverse effects, which may include low blood sugar, pancreatitis, increased body weight, lactic acidosis, diarrhoea, and hepatic and cardiac issues among patients (Khursheed et al ., 2019). Numerous research teams are concentrating their efforts on exploring conventional remedies or natural botanical products in order to develop novel and more effective compounds that offer fewer adverse effects compared to contemporary medicinal drugs (Asghar et al ., 2021; Perumal et al ., 2022).…”

Section: Introductionmentioning

confidence: 99%

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Antidiabetic potential of ethanolic crude extract of Garcinia atroviridis fruits: in vitro, in ovo, and in silico analysis

Shahid,

Fazry,

Najm

et al. 2024

Int J of Food Sci Tech

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SummaryVarious parts of Garcinia atroviridis have long been used to address various health issues and as a seasoning. Past research has highlighted the leaf extracts' diverse medicinal properties, including antioxidant, antihyperlipidaemic, antibacterial, antitumor, anti‐inflammatory, and antifungal effects. No research has explored the therapeutic effects of the ethanolic crude extract of G. atroviridis fruits (GAECE) for diabetes. This study aims to assess GAECE's antidiabetic potential using various methods, including in vitro and in ovo assays, cytotoxicity testing, phytochemical profiling, and in silico analysis to identify active compounds. The GAECE was prepared using the maceration method and evaluated for its inhibitory effect against DPP‐4, α‐glucosidase, and α‐amylase enzyme activities. The glucose uptake potential and the kinetic study of glucose uptake were performed to determine the time required to exert its glucose uptake potential. Moreover, the antihyperglycaemic effect was evaluated in diabetes induced in ovo model. Q‐TOF LCMS was performed to identify the phytochemical, which was then subjected to molecular docking and molecular dynamics (MD) simulation was conducted for 100 nanoseconds to validate the ligand–receptor complexes. GAECE exhibited promising antidiabetic potential, with half maximal inhibitory concentrations (IC50) of 0.129 ± 0.002 mg mL−1 for α‐amylase and 0.593 ± 0.01 mg mL−1 for α‐glucosidase; and showed an inhibition of 70.07 ± 0.96% for DPP‐4 enzymes at 0.5 mg mL−1. The 50% cell viability was found to be 0.87 ± 0.08 mg mL−1, 0.76 ± 0.04 mg mL−1, and 0.66 ± 0.03 mg mL−1 for 24, 48, and 72 h of treatment, respectively. Furthermore, GAECE showed potential for glucose uptake in differentiated L6 cells, resulting in a 136.7 ± 1.2% increase in glucose uptake. Kinetic analysis revealed peak potential at 10 min at the concentration of 0.4 mg mL−1. In in ovo diabetes induced model, GAECE reduced blood plasma glucose levels (152.4 ± 0.52 mg dL−1), which was similar to the effect of insulin.

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Section: In Vitro Antidiabetic Assays α-Amylase Inhibition Assaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antidiabetic potential of ethanolic crude extract of Garcinia atroviridis fruits: in vitro, in ovo, and in silico analysis

Shahid,

Fazry,

Najm

et al. 2024

Int J of Food Sci Tech

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“…In contrast, in alcoholic extracts, the enzymes may be active. The different antioxidant activity results could be due to the differences in the vegetal material, solvents utilised for extraction, and the chemical composition of the extracts 25 The method and conditions of extraction (temperature and time) could also affect the antioxidant activity 26 of an extract with a phenolic compound with many hydroxyl groups. 27…”

Section: Total Antioxidant Capacitymentioning

confidence: 99%

Effect of Extraction Solvent on Total Phenol Content, Total Flavonoid Content, and Antioxidant Activity of Euphorbia resinifiera O. Berg

2023

TJNPR

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Euphorbia resinifiera is a well-known medicinal plant used by the Moroccans to treat several diseases. This study evaluated the influence of extraction solvents polarities (methanol, aqueous/methanol (3:7), and distilled water) on the polyphenols and flavonoids contents of Euphorbia resinifiera extracts obtained by three extraction methods: infusion, maceration and sonication, as well as their antioxidant activity. The results revealed that the distilled water extract obtained by infusion presented the highest polyphenols and flavonoids contents: 8.89 ±0.01 mgGEA/g dry weight, and 4.98±0.01 mgRE/g dry weight, respectively. The antioxidant activity results revealed that the aqueous-methanol extracts showed the highest antioxidant activity. These findings could support the medical uses of Euphorbia resinifiera.

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“…Perumal et al 2022 [ 50 ] studied the antidiabetic potential of a combination of dandelion and Momordica charantia extracts. They determined antidiabetic properties in vitro; the inhibition of α-amylase, α-glucosidase, and dipeptidyl peptidase-4 (DPP-4), and glucose-uptake in L6 muscle cells.…”

Section: Pharmacological Activity Of Dandelion For Potential Use In T...mentioning

confidence: 99%

“…A glucose tolerance test in a study involving rats with streptozotocin–nicotinamide (STZ-NA)-induced diabetes proved that the combination of herbs tested lowered blood glucose levels comparable to the effects of glibenclamide and metformin. The combination of herb extracts showed better antidiabetic properties; it increased the activity of DPP-4, α-amylase, and α-glucosidase [ 50 ]. Therefore, the authors suggest that combinations of herbs have a better phytotherapeutic potential for treating type 2 diabetes.…”

Section: Pharmacological Activity Of Dandelion For Potential Use In T...mentioning

confidence: 99%

Dandelion (Taraxacum officinale L.) as a Source of Biologically Active Compounds Supporting the Therapy of Co-Existing Diseases in Metabolic Syndrome

Kania-Dobrowolska

Baraniak

2022

Foods

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Nowadays, many people are struggling with obesity, type 2 diabetes, and atherosclerosis, which are called the scourge of the 21st century. These illnesses coexist in metabolic syndrome, which is not a separate disease entity because it includes several clinical conditions such as central (abdominal) obesity, elevated blood pressure, and disorders of carbohydrate and fat metabolism. Lifestyle is considered to have an impact on the development of metabolic syndrome. An unbalanced diet, the lack of sufficient physical activity, and genetic factors result in the development of type 2 diabetes and atherosclerosis, which significantly increase the risk of cardiovascular complications. The treatment of metabolic syndrome is aimed primarily at reducing the risk of the development of coexisting diseases, and the appropriate diet is the key factor in the treatment. Plant raw materials containing compounds that regulate lipid and carbohydrate metabolism in the human body are investigated. Dandelion (Taraxacum officinale F.H. Wigg.) is a plant, the consumption of which affects the regulation of lipid and sugar metabolism. The growth of this plant is widely spread in Eurasia, both Americas, Africa, New Zealand, and Australia. The use and potential of this plant that is easily accessible in the world in contributing to the treatment of type 2 diabetes and atherosclerosis have been proved by many studies.

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Synergistic antidiabetic activity of Taraxacum officinale (L.) Weber ex F.H.Wigg and Momordica charantia L. polyherbal combination

Cited by 18 publications

References 52 publications

Antidiabetic potential of ethanolic crude extract of Garcinia atroviridis fruits: in vitro, in ovo, and in silico analysis

Antidiabetic potential of ethanolic crude extract of Garcinia atroviridis fruits: in vitro, in ovo, and in silico analysis

Effect of Extraction Solvent on Total Phenol Content, Total Flavonoid Content, and Antioxidant Activity of Euphorbia resinifiera O. Berg

Dandelion (Taraxacum officinale L.) as a Source of Biologically Active Compounds Supporting the Therapy of Co-Existing Diseases in Metabolic Syndrome

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