Synergistic antidepressant-like effect of n-3 polyunsaturated fatty acids and probiotics through the brain-gut axis in rats exposed to chronic mild stress

Cho, Hyunji; Jo, Miyea; Oh, Haemin; Lee, Yunjung; Park, Yongsoon

doi:10.1016/j.jnutbio.2023.109326

Cited by 4 publications

(2 citation statements)

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“… 66 Some specific probiotics may inhibit excessive stress responses in social interactions and improve emotional and anxiety symptoms in response to chronic stress by restraining corticosterone and catecholamine production. 67 Probiotics not only improves depressive behavior by increasing glucocorticoid receptor expression and decreasing adrenocorticotropin‐releasing factor expression, adrenocorticotropic hormone, and corticosterone levels in the blood, 68 but also attenuates the homeostasis disruption caused by stress, regulates cortical brain‐derived neurotrophic factor (BDNF) expression, and inhibits over‐response to stress in the hippocampus and HPA axis. 69 …”

Section: Potential Mechanisms By Which Gut Microbiota Affects Neurode...mentioning

confidence: 99%

Treatment of preterm brain injury via gut‐microbiota–metabolite–brain axis

Li,

Liu,

Shi

2023

CNS Neurosci Ther

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BackgroundBrain injury in preterm infants potentially disrupts critical structural and functional connective networks in the brain. It is a major cause of neurological sequelae and developmental deficits in preterm infants. Interesting findings suggest that the gut microbiota (GM) and their metabolites contribute to the programming of the central nervous system (CNS) during developmental stages and may exert structural and functional effects throughout the lifespan.AimTo summarize the existing knowledge of the potential mechanisms related to immune, endocrine, neural, and blood–brain barrier (BBB) mediated by GM and its metabolites in neural development and function.MethodsWe review the recent literature and included 150 articles to summarize the mechanisms through which GM and their metabolites work on the nervous system. Potential health benefits and challenges of relevant treatments are also discussed.ResultsThis review discusses the direct and indirect ways through which the GM may act on the nervous system. Treatment of preterm brain injury with GM or related derivatives, including probiotics, prebiotics, synbiotics, dietary interventions, and fecal transplants are also included.ConclusionThis review summarizes mechanisms underlying microbiota‐gut‐brain axis and novel therapeutic opportunities for neurological sequelae in preterm infants. Optimizing the initial colonization and microbiota development in preterm infants may represent a novel therapy to promote brain development and reduce long‐term sequelae.

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Section: Potential Mechanisms By Which Gut Microbiota Affects Neurode...mentioning

confidence: 99%

Treatment of preterm brain injury via gut‐microbiota–metabolite–brain axis

Li,

Liu,

Shi

2023

CNS Neurosci Ther

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“…The beneficial effects of probiotics on stress response have been confirmed. Probiotics can synergistically promote the expression of glucocorticoid receptors with N-3 polyunsaturated fatty acids (PUFA), reduce adrenocorticotropic hormone expression, and lower corticosterone levels in the blood [6]. Lactobacillus acidophilus can decrease cortisol levels in the blood of suckling piglets challenged with lipopolysaccharides, and reduce the levels of white blood cells, neutrophils, and lymphocytes in the blood [7].…”

Section: Introductionmentioning

confidence: 99%

Effect of Composite Probiotics on Antioxidant Capacity, Gut Barrier Functions, and Fecal Microbiome of Weaned Piglets and Sows

Tang,

Zhao,

Yang

et al. 2024

Animals

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This study investigated the efficacy of a composite probiotics composed of lactobacillus plantarum, lactobacillus reuteri, and bifidobacterium longum in alleviating oxidative stress in weaned piglets and pregnant sows. Evaluations of growth, oxidative stress, inflammation, intestinal barrier, and fecal microbiota were conducted. Results showed that the composite probiotic significantly promoted average daily gain in piglets (p < 0.05). It effectively attenuated inflammatory responses (p < 0.05) and oxidative stress (p < 0.05) while enhancing intestinal barrier function in piglets (p < 0.01). Fecal microbiota analysis revealed an increase in the abundance of beneficial bacteria such as faecalibacterium, parabacteroides, clostridium, blautia, and phascolarctobacterium in piglet feces and lactobacillus, parabacteroides, fibrobacter, and phascolarctobacterium in sow feces, with a decrease in harmful bacteria such as bacteroides and desulfovibrio in sow feces upon probiotic supplementation. Correlation analysis indicated significant negative associations of blautia with inflammation and oxidative stress in piglet feces, while treponema and coprococcus showed significant positive associations. In sow feces, lactobacillus, prevotella, treponema, and CF231 exhibited significant negative associations, while turicibacter showed a significant positive association. Therefore, the composite probiotic alleviated oxidative stress in weaned piglets and pregnant sows by modulating fecal microbiota composition.

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