Synergistic Anticancer Strategy of Sonodynamic Therapy Combined with PI-103 Against Hepatocellular Carcinoma

Yang, Huajing; Jing, Hui; Han, Xue; Tan, Haoyan; Cheng, Wen

doi:10.2147/dddt.s296880

Cited by 13 publications

(5 citation statements)

References 41 publications

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“…SDT is effective in treating a variety of tumors (Um et al, 2021). Recently, the application of SDT has been studied extensively (Wang et al, 2021), and our team also showed that SDT could promote cell apoptosis through the mitochondrial pathway in HCC cells (Yang et al, 2021).…”

Section: Introductionmentioning

confidence: 80%

RNA-Seq Technology Reveals the Mechanism of SDT Combined With Novel Nanobubbles Against HCC

Shang

Chen

Wang

et al. 2022

Front. Mol. Biosci.

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Sonodynamic therapy is widely used in the treatment and research of hepatocellular carcinoma. A novel targeted nanobubble complex mediated with Hematoporphyrin monomethyl ether and Lonidamine was structured as a sensitizer, characterized the properties, and studied the therapeutic effect on hepatocellular carcinoma. The complexes can promote the apoptosis of hepatocellular carcinoma cells and work better in combination with sonodynamic therapy. The differential expression of multiple types of RNA in hepatocellular carcinoma with sonodynamic therapy can be identified accurately with high-throughput RNA sequencing. The differential expressions of mRNA, lncRNA, and circRNA were analyzed by RNA-Seq. The enrichment analyses (Gene Ontology and KEGG) prompted the meaningful genes and pathways in the process of sonodynamic therapy in hepatocellular carcinoma cells. HMME-LND@C3F8-NBs conjugated with ultrasound is confirmed efficiently for inhibiting the development of hepatocellular carcinoma cells, and it is a combination of multiple genes and mechanisms.

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Section: Introductionmentioning

confidence: 80%

RNA-Seq Technology Reveals the Mechanism of SDT Combined With Novel Nanobubbles Against HCC

Shang

Chen

Wang

et al. 2022

Front. Mol. Biosci.

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“…Meanwhile, FAM3D expression was negatively correlated with PI-103 drug sensitivity. PI-103 is a DNA-PK/PI3K/mTOR inhibitor that has been used in preclinical studies, and demonstrated anti-proliferative effects on a variety of cancer types 57 , 58 . To sum up, the results of drug sensitivity analysis could help us understand the associations between FAM3 family genes expression and numerous anticancer drugs, which provided some ideas for exploring tumor therapy and avoiding tumor drug resistance.…”

Section: Discussionmentioning

confidence: 99%

FAM3 family genes are associated with prognostic value of human cancer: a pan-cancer analysis

Dong,

Ma,

Gong

et al. 2023

Sci Rep

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Family with sequence similarity three member (FAM3) plays a crucial role in the malignant development of various cancers of human. However, there remains doubtful what specific role of FAM3 family genes in pan-cancer. Our study aimed to investigate the role of FAM3 family genes in prognosis, immune subtype, tumor immune microenvironment, stemness score, and anticancer drug sensitivity of pan-cancer. We obtained data from UCSC Xena GDC and CellMiner databases, and used them to study the correlation of the expression, survival, immune subtype, tumor microenvironment, stemness score, and anticancer drug sensitivity between FAM3 family genes with pan-cancer. Furthermore, we investigated the tumor cellular functions and clinical prognostic value FAMC3 in pancreatic cancer (PAAD) using cellular experiments and tissue microarray. Cell Counting Kit-8 (CCK-8), transwell invasion, wound-healing and apoptosis assays were performed to study the effect of FAM3C on SW1990 cells’ proliferation, migration, invasion and apoptosis. Immunohistochemical staining was used to study the relationship between FAM3C expression and clinical characteristics of pancreatic cancer patients. The results revealed that FAM3 family genes are significantly differential expression in tumor and adjacent normal tissues in 7 cancers (CHOL, HNSC, KICH, LUAD, LUSC, READ, and STAD). The expression of FAM3 family genes were negatively related with the RNAss, and robust correlated with immune type, tumor immune microenvironment and drug sensitivity. The expression of FAM3 family genes in pan-cancers were significantly different in immune type C1 (wound healing), C2 (IFN-gamma dominant), C3 (inflammatory), C4 (lymphocyte depleted), C5 (immunologically quiet), and C6 (TGF-beta dominant). Meanwhile, overexpression FAM3C promoted SW1990 cells proliferation, migration, invasion and suppressed SW1990 cells apoptosis. While knockdown of FAM3C triggered opposite results. High FAM3C expression was associated with duodenal invasion, differentiation and liver metastasis. In summary, this study provided a new perspective on the potential therapeutic role of FAM3 family genes in pan-cancer. In particular, FAM3C may play an important role in the occurrence and progression of PAAD.

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“…Meanwhile, FAM3D expression was negatively correlated with PI-103 drug sensitivity. PI-103 is a DNA-PK/PI3K/mTOR inhibitor that has been used in preclinical studies, and demonstrated anti-proliferative effects on a variety of cancer types [53,54]. To sum up, The results of drug sensitivity analysis could help us understand the associations between FAM3 family genes expression and numerous anticancer drugs, which provided some ideas for exploring tumor therapy and avoiding tumor drug resistance.…”

Section: Discussionmentioning

confidence: 99%

FAM3 family genes are associated with prognostic value of human cancer: a pan-cancer analysis

Dong

Gong

et al. 2022

Preprint

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Background: Family with sequence similarity three member (FAM3) plays a crucial role in the malignant development of various cancers of human. Our study aimed to investigate the role of FAM3 family genes in prognosis, immune subtype, tumor immune microenvironment, stemness score, and anticancer drug sensitivity of pan-cancer. Methods: The expression, survival, immune subtype, tumor microenvironment, stemness score, and anticancer drug sensitivity analysis data of FAM3 family genes associated with pan-cancer from UCSC Xena GDC and CellMiner databases. Furthermore, we investigated the tumor cellular functions and clinical prognostic value FAMC3 in pancreatic cancer (PAAD) using cellular experiments and tissue microarray. Results: The results revealed that FAM3 family genes are significantly differential expression in tumor and adjacent normal tissues in 7 cancers (CHOL, HNSC, KICH, LUAD, LUSC, READ, and STAD). The expression of FAM3 family genes were negatively related with the RNAss, and robust correlated with immune type, tumor immune microenvironment and drug sensitivity. Meanwhile, overexpression FAM3C promoted PAAD cell proliferation, migration, invasion and suppressed PAAD cell apoptosis. While knockdown of FAM3C triggered opposite results. High FAM3C expression was associated with duodenal invasion, differentiation and liver metastasis. Conclusion: This study provided a new perspective on the potential therapeutic role of FAM3 family genes in pan-cancer. In particular, FAM3C may be a new marker for PAAD, providing a new idea for the treatment of PAAD.

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Synergistic Anticancer Strategy of Sonodynamic Therapy Combined with PI-103 Against Hepatocellular Carcinoma

Cited by 13 publications

References 41 publications

RNA-Seq Technology Reveals the Mechanism of SDT Combined With Novel Nanobubbles Against HCC

RNA-Seq Technology Reveals the Mechanism of SDT Combined With Novel Nanobubbles Against HCC

FAM3 family genes are associated with prognostic value of human cancer: a pan-cancer analysis

FAM3 family genes are associated with prognostic value of human cancer: a pan-cancer analysis

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