2014
DOI: 10.5897/ajpp2013.3797
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Synergistic anticancer effects of valproic acid, atorvastatin and pioglitazone in human malignant and murine cells

Abstract: Valproic acid, atorvastatin and pioglitazone belong to different therapeutic drug classes and exhibit biological activities that are capable of interfering with cancer development. In this study, we examined the anticancer synergistic effects of these three drugs in experimental models in vitro and in vivo. Cytotoxic activity was determined against K562, NCI-H292 and HEp-2 lines cells. The Ehrlich carcinoma was used as in vivo model. Atorvastatin associated with pioglitazone, presented cytotoxicity against NCI… Show more

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“…12,19 Other statin drug, fluvastatin also showed cytotoxic effect against C6 glioma cancer cells. 18 In addition, atorvastatin was active against NCI-H292 cancer cells with an IC 50 value of 5.54 µg/mL 20 and lovastatin was active against MDAMB468 and MDAMB231 cancer cells with IC 50 values of 8 μg/mL and 5 μg/mL, respectively. 21…”
Section: Cytotoxic Activity Of Simvastatinmentioning
confidence: 99%
“…12,19 Other statin drug, fluvastatin also showed cytotoxic effect against C6 glioma cancer cells. 18 In addition, atorvastatin was active against NCI-H292 cancer cells with an IC 50 value of 5.54 µg/mL 20 and lovastatin was active against MDAMB468 and MDAMB231 cancer cells with IC 50 values of 8 μg/mL and 5 μg/mL, respectively. 21…”
Section: Cytotoxic Activity Of Simvastatinmentioning
confidence: 99%