Synergistic Antibacterial Activity of Plant Peptide MBP-1 and Silver Nanoparticles Combination on Healing of Infected Wound Due to Staphylococcus aureus

Salouti, Mojtaba; Mirzaei, Fatemeh; Shapouri, Reza; Ahangari, Azam

doi:10.5812/jjm.27997

Cited by 17 publications

(13 citation statements)

References 18 publications

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“…Thus, MBP-1 protein is expected to be developed as a new pharmaceutical ingredient for cancer treatment and prevention. Salouti et al have found the synergistic effect on the healing of infected wounds caused by Staphylococcus aureus by using a plant peptide MBP-1 and silver nanoparticles combination in a mouse model [69]. Additionally, the apoptosis induced by etoposide, doxorubicin, and cisplatin which are currently used in cancer therapy can be enhanced by c-Myc overexpression in NIH3T3 mouse fibroblasts, TGR-1, HO15.19, and HOmyc3 Rat1 cell lines [70] Therefore, it is worth studying whether these drugs can target MBP-1.…”

Section: The Developing Potential Of Mbp-1 In Pharmaceuticalsmentioning

confidence: 99%

The Biological Significance and Regulatory Mechanism of c-Myc Binding Protein 1 (MBP-1)

Liu

Zhang

Zheng

et al. 2018

IJMS

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Alternatively translated from the ENO gene and expressed in an array of vertebrate and plant tissues, c-Myc binding protein 1 (MBP-1) participates in the regulation of growth in organisms, their development and their environmental responses. As a transcriptional repressor of multiple proto-oncogenes, vertebrate MBP-1 interacts with other cellular factors to attenuate the proliferation and metastasis of lung, breast, esophageal, gastric, bone, prostrate, colorectal, and cervical cancer cells. Due to its tumor-suppressive property, MBP-1 and its downstream targets have been investigated as potential prognostic markers and therapeutic targets for various cancers. In plants, MBP-1 plays an integral role in regulating growth and development, fertility and abiotic stress responses. A better understanding of the functions and regulatory factors of MBP-1 in plants may advance current efforts to maximize plant resistance against drought, high salinity, low temperature, and oxidative stress, thus optimizing land use and crop yields. In this review article, we summarize the research advances in biological functions and mechanistic pathways underlying MBP-1, describe our current knowledge of the ENO product and propose future research directions on vertebrate health as well as plant growth, development and abiotic stress responses.

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Section: The Developing Potential Of Mbp-1 In Pharmaceuticalsmentioning

confidence: 99%

The Biological Significance and Regulatory Mechanism of c-Myc Binding Protein 1 (MBP-1)

Liu

Zhang

Zheng

et al. 2018

IJMS

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“…MIC and MBC of the AgNPs and MBP-1 combination were found to be 3.125 mg/mL, 0.5 mg/L; and 6.25 mg/mL, 0.6 mg/L, respectively. The synergistic antibacterial effect of Ag NPs and MBP-1 was investigated on infected wounds caused by S. aureus in a mouse model, and the infected wound healed properly after the combined use of MBP-1 and AgNPs [44]. It is worth to note recent findings by Chaudhari et al concerning the conjugation of silver-coated carbon nanotubes with the antimicrobial peptide TP359.…”

Section: Silver Nanoparticlesmentioning

confidence: 97%

“…For instance, hydrogels, that can be potentially applied in wound dressing development [43]. Also addressing the wound infection problem, Salouti et al investigated the synergistic antibacterial effect of plant peptide MBP-1 and AgNPs on infected wounds caused by S. aureus [44]. The MIC and MBC of MBP-1 and AgNPs both on their own and in combination form were determined against S. aureus via macrodilution and microdilution methods.…”

Section: Silver Nanoparticlesmentioning

confidence: 99%

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Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs)

et al. 2020

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Microbial infections are still among the major public health concerns since several yeasts and fungi, and other pathogenic microorganisms, are responsible for continuous growth of infections and drug resistance against bacteria. Antimicrobial resistance rate is fostering the need to develop new strategies against drug-resistant superbugs. Antimicrobial peptides (AMPs) are small peptide-based molecules of 5-100 amino acids in length, with potent and broad-spectrum antimicrobial properties. They are part of the innate immune system, which can represent a minimal risk of resistance development. These characteristics contribute to the description of these molecules as promising new molecules in the development of new antimicrobial drugs. However, efforts in developing new medicines have not resulted in any decrease of drug resistance yet. Thus, a technological approach on improving existing drugs is gaining special interest. Nanomedicine provides easy access to innovative carriers, which ultimately enable the design and development of targeted delivery systems of the most efficient drugs with increased efficacy and reduced toxicity. Based on performance, successful experiments, and considerable market prospects, nanotechnology will undoubtedly lead a breakthrough in biomedical field also for infectious diseases, as there are several nanotechnological approaches that exhibit important roles in restoring antibiotic activity against resistant bacteria.

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“…The effect of AgNPs along with MBP-1 peptide was studied on the disease-causing bacteria S.aureus which is commonly resistant to many antibiotics. The wound caused by the bacteria has been found to heal and the bacterial colonization also decreased at the wound site due to mutual effect of both the AgNPs and MBP-1 peptide [19]. The specific peptide sequence of arginine, glycine, aspartic acid (RGD) interacts with integrin receptors in various adhesion processes for cell targeting.…”

Section: Metallic Nanoparticlesmentioning

confidence: 99%

Nanomaterials as Protein, Peptide and Gene Delivery Agents

Guliani¹,

Acharya²

2018

TOBIOTJ

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Background:Nanomaterials offer significant advantages in delivery of different biomolecules which suffer from drawbacks like poor bioavailability, low stability and retention time, degradation in biological systemsetc. Nanotechnological approach has shown promising results for the sustained release of these biomolecules with minimal toxicity concerns. The present review describes a comprehensive outlook of the different nanomaterials used for the delivery of these biomolecules.Methods:Current literature reports related to protein, peptide and gene delivery agents have been reviewed and classified according to their applications.Results:Studies suggested that the nanomaterial based delivery agents can be broadly classified in to five categories which include metallic NPs, polymeric NPs, magnetic NPs, liposomes and micelles. All these materials provided significant improvement in the targeted delivery of biomolecules.Conclusion:Concerns regarding the bioavailability, stability and delivery of proteins, peptides, genes need to be investigated to improve their therapeutic potential in the biological milieu. The use of nanoparticles as drug delivery vehicles may avoid undesirable hazards and may increase their pharmaceutical efficacy.

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Synergistic Antibacterial Activity of Plant Peptide MBP-1 and Silver Nanoparticles Combination on Healing of Infected Wound Due to Staphylococcus aureus

Cited by 17 publications

References 18 publications

The Biological Significance and Regulatory Mechanism of c-Myc Binding Protein 1 (MBP-1)

The Biological Significance and Regulatory Mechanism of c-Myc Binding Protein 1 (MBP-1)

Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs)

Nanomaterials as Protein, Peptide and Gene Delivery Agents

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