Synergistic Antibacterial Activity and Wound Healing Properties of Selenium-Chitosan-Mupirocin Nanohybrid System: An in Vivo Study on Rat Diabetic Staphylococcus aureus Wound Infection Model

Golmohammadi, Reza; Peerayeh, Shahin Najar; Moghadam, Tahereh Tohidi; Hosseini, Seyed Mohammad

doi:10.1038/s41598-020-59510-5

Cited by 50 publications

(21 citation statements)

References 69 publications

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“…An increase of tissue force with higher resistance of the scar due to organization of collagen may justify this detected delay ( 68 ). Without evident detrimental effects on healing ( 69 ), MU could injure keratinocytes and fibroblasts of healthy skin ( 68 ) what stimulates new formulations ( 70 ) or synergistic antimicrobial combinations with best healing properties ( 71 ). Hyperkeratosis/clinical desquamation in MU-wounds shows clinical-histological correspondence with an excess of keratin production and superficial cutaneous desquamation in nude mice ( 23 ); this could have a double explanation: uncontrolled wound healing in untreated wounds or changes of lipid layer of skin as secondary effect of repetitive dose of topical MU in humans (drug commercial package) and possibly in SKH-1 mice.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Antibacterial Activity and Wound Healing in a Superficial Abrasion Mouse Model of Staphylococcus aureus Skin Infection Using Photodynamic Therapy Based on Methylene Blue or Mupirocin or Both

et al. 2021

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Background: Antibiotic resistance and impaired wound healing are major concerns in S. aureus superficial skin infections, and new therapies are needed. Antimicrobial photodynamic therapy (aPDT) is a new therapeutic approach for infections, but it also improves healing in many wound models.Objective: To compare the antimicrobial activity and the effects on wound healing of aPDT based on Methylene Blue (MB-aPDT) with mupirocin treatment, either alone or in combination, in superficial skin wounds of S. aureus-infected mice. Additionally, to evaluate the clinical, microbiological, and cosmetic effects on wound healing.Materials and Methods: A superficial skin infection model of S. aureus was established in SKH-1 mice. Infected wounds were treated with MB-aPDT, MB-aPDT with a daily topical mupirocin or only with mupirocin. No treatment was carried out in control animals. Daily clinical and microbiological examinations were performed until complete clinical wound healing. Histopathological studies and statistical analysis were performed at the end of the study.Results: MB-aPDT treatment induced the best wound healing compared to mupirocin alone or to mupirocin plus MB-aPDT. Superficial contraction at 24 h and a greater reduction in size at 48 h, quicker detachment of the crust, less scaling, and absence of scars were observed. Histopathological studies correlated with clinical and gross findings. By contrast, mupirocin showed the highest logaritmic reduction of S. aureus.Conclusions: MB-aPDT and mupirocin treatments are effective in a murine superficial skin infection model of S. aureus. One session of MB-aPDT was the best option for clinical wound healing and cosmetic results. The addition of mupirocin to MB-aPDT treatment improved antimicrobial activity; however, it did not enhance wound healing. No synergistic antibacterial effects were detected.

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Section: Discussionmentioning

confidence: 99%

Comparison of Antibacterial Activity and Wound Healing in a Superficial Abrasion Mouse Model of Staphylococcus aureus Skin Infection Using Photodynamic Therapy Based on Methylene Blue or Mupirocin or Both

et al. 2021

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“…The therapeutic combination within the hydrogel demonstrated synergic activities against mupirocin‐methicillin‐resistant S. aureus (MMRSA) inoculated in an injury created in a diabetic rat model, while improving the wound healing associated with the bacterial infection, stimulating epidermal growth, and decreasing the associated inflammation, suggesting its potential for treatment of diabetic wound infections. [ 204 ] SeNPs produced by biosynthesis using Lactococcus lactis had a protective effect on intestinal infection by E. coli , preserving the intestinal epithelial barrier due to its antioxidant and anti‐inflammatory effects and by increasing occludin an claudin‐1 expression. [ 78 ]…”

Section: Senps For Pharmaceutical Applicationsmentioning

confidence: 99%

Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

Ferro

Florindo

Santos

2021

Adv Healthcare Materials

191

109

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Selenium (Se) is an essential element to human health that can be obtained in nature through several sources. In the human body, it is incorporated into selenocysteine, an amino acid used to synthesize several selenoproteins, which have an active center usually dependent on the presence of Se. Although Se shows several beneficial properties in human health, it has also a narrow therapeutic window, and therefore the excessive intake of inorganic and organic Se‐based compounds often leads to toxicity. Nanoparticles based on Se (SeNPs) are less toxic than inorganic and organic Se. They are both biocompatible and capable of effectively delivering combinations of payloads to specific cells following their functionalization with active targeting ligands. Herein, the main origin of Se intake, its role on the human body, and its primary biomedical applications are revised. Particular focus will be given to the main therapeutic targets that are explored for SeNPs in cancer therapies, discussing the different functionalization methodologies used to improve SeNPs stability, while enabling the extensive delivery of drug‐loaded SeNP to tumor sites, thus avoiding off‐target effects.

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“…The incorporation of antibiotics into chitosan hydrogels can enhance their efficacy in treating wound infections. For example, mupirocin was added to chitosan-cetyltrimethyl ammonium bromide hydrogels to effectively resist infections caused by S. aureus and Streptococcus pyogenes ( S. pyogenes ) ( Golmohammadi et al, 2020 ).…”

Section: Function and Application Of Hydrogel-like Chitosan-based Matmentioning

confidence: 99%

Chitosan-Based Functional Materials for Skin Wound Repair: Mechanisms and Applications

Feng

Luo

et al. 2021

Front. Bioeng. Biotechnol.

222

100

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Skin wounds not only cause physical pain for patients but also are an economic burden for society. It is necessary to seek out an efficient approach to promote skin repair. Hydrogels are considered effective wound dressings. They possess many unique properties like biocompatibility, biodegradability, high water uptake and retention etc., so that they are promising candidate materials for wound healing. Chitosan is a polymeric biomaterial obtained by the deacetylation of chitin. With the properties of easy acquisition, antibacterial and hemostatic activity, and the ability to promote skin regeneration, hydrogel-like functional wound dressings (represented by chitosan and its derivatives) have received extensive attentions for their effectiveness and mechanisms in promoting skin wound repair. In this review, we extensively discussed the mechanisms with which chitosan-based functional materials promote hemostasis, anti-inflammation, proliferation of granulation in wound repair. We also provided the latest information about the applications of such materials in wound treatment. In addition, we summarized the methods to enhance the advantages and maintain the intrinsic nature of chitosan via incorporating other chemical components, active biomolecules and other substances into the hydrogels.

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Synergistic Antibacterial Activity and Wound Healing Properties of Selenium-Chitosan-Mupirocin Nanohybrid System: An in Vivo Study on Rat Diabetic Staphylococcus aureus Wound Infection Model

Cited by 50 publications

References 69 publications

Comparison of Antibacterial Activity and Wound Healing in a Superficial Abrasion Mouse Model of Staphylococcus aureus Skin Infection Using Photodynamic Therapy Based on Methylene Blue or Mupirocin or Both

Comparison of Antibacterial Activity and Wound Healing in a Superficial Abrasion Mouse Model of Staphylococcus aureus Skin Infection Using Photodynamic Therapy Based on Methylene Blue or Mupirocin or Both

Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

Chitosan-Based Functional Materials for Skin Wound Repair: Mechanisms and Applications

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